2007
Local Administration of Interleukin-11 Ameliorates Intestinal Radiation Injury in Rats
Boerma M, Wang J, Burnett AF, Santin AD, Roman JJ, Hauer-Jensen M. Local Administration of Interleukin-11 Ameliorates Intestinal Radiation Injury in Rats. Cancer Research 2007, 67: 9501-9506. PMID: 17909060, DOI: 10.1158/0008-5472.can-07-0810.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHumansInterleukin-11Intestinal DiseasesIntestinal MucosaIntestinesMaleMast CellsRadiation Injuries, ExperimentalRatsRats, Sprague-DawleyRecombinant ProteinsTransforming Growth Factor betaConceptsIntestinal radiation injuryRadiation injuryRhIL-11Bowel loopsMucosal mast cell numbersIL-11Whole body radiation exposureRecombinant human IL-11Small bowel loopsED2-positive cellsRadiation injury scoreIntestinal wall thickeningMast cell numbersIntestinal radiation responseLocal administrationHuman IL-11Pelvic radiotherapySurgical transpositionIntraluminal administrationInjury scoreIntestinal loopsMale ratsSystemic administrationSevere toxicityDrug Administration
2001
Increased levels of interleukin‐10 and transforming growth factor‐β in the plasma and ascitic fluid of patients with advanced ovarian cancer
Santin A, Bellone S, Ravaggi A, Roman J, Smith C, Pecorelli S, Cannon M, Parham G. Increased levels of interleukin‐10 and transforming growth factor‐β in the plasma and ascitic fluid of patients with advanced ovarian cancer. BJOG An International Journal Of Obstetrics & Gynaecology 2001, 108: 804-808. PMID: 11510703, DOI: 10.1111/j.1471-0528.2001.00206.x.Peer-Reviewed Original ResearchConceptsOvarian cancer patientsAdvanced ovarian cancerIL-10Cancer patientsOvarian cancerAscitic fluidPlasma levelsPeritoneal fluidAdvanced ovarian cancer patientsElevated TGF-beta levelsImmunosuppressive cytokine IL-10Anti-tumor immune functionDetectable IL-10TGF-beta levelsCytokine IL-10Time of surgeryDepartment of ObstetricsTGF-beta releasePlasma samplesNormal female controlsSensitive enzyme-linked immunosorbentEnzyme-linked immunosorbentImmunosuppressive cytokinesInterleukin-10Prospective study
1997
Differential Transforming Growth Factor-β Secretion in Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix
Santin A, Hermonat P, Hiserodt J, Fruehauf J, Schranz V, Barclay D, Pecorelli S, Parham G. Differential Transforming Growth Factor-β Secretion in Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix. Gynecologic Oncology 1997, 64: 477-480. PMID: 9062154, DOI: 10.1006/gyno.1996.4579.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaCarcinoma, Squamous CellFemaleHumansTransforming Growth Factor betaTumor Cells, CulturedUterine Neoplasms
1996
Differential Effects of High-Dose Gamma Irradiation on the Production of Transforming Growth Factor-Beta in Fresh and Established Human Ovarian Cancer
Santin A, Hiserodt J, DiSaia P, Pecorelli S, Granger G. Differential Effects of High-Dose Gamma Irradiation on the Production of Transforming Growth Factor-Beta in Fresh and Established Human Ovarian Cancer. Gynecologic Oncology 1996, 61: 403-408. PMID: 8641623, DOI: 10.1006/gyno.1996.0164.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsFemaleGamma RaysHumansInterferon-gammaOvarian NeoplasmsRadiotherapy DosageTransforming Growth Factor betaTumor Cells, CulturedTumor Necrosis Factor-alphaConceptsOvarian carcinoma cell linesCarcinoma cell linesOvarian tumorsFresh tumorsCell linesHigh dosesImmunoinhibitory cytokinesTumor cellsFresh ovarian tumorsTGF-beta secretionTGF-beta productionCytokines TNF-alphaFresh tumor cellsWeak immunological responseFresh tumor samplesHuman ovarian cancerHuman ovarian carcinoma cell linesTNF-alphaOvarian cancerImmunological responseIFN-gammaCytokinesTumorsTumor samplesContinuous cell lines