2008
A novel CD4 T-cell epitope described from one of the cervical cancer patients vaccinated with HPV 16 or 18 E7-pulsed dendritic cells
Wang X, Santin AD, Bellone S, Gupta S, Nakagawa M. A novel CD4 T-cell epitope described from one of the cervical cancer patients vaccinated with HPV 16 or 18 E7-pulsed dendritic cells. Cancer Immunology, Immunotherapy 2008, 58: 301-308. PMID: 18446336, PMCID: PMC2782377, DOI: 10.1007/s00262-008-0525-2.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAntigen PresentationCancer VaccinesCD4 AntigensDendritic CellsDose-Response Relationship, DrugEpitopes, T-LymphocyteFemaleHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHuman papillomavirus 16Human papillomavirus 18HumansMolecular Sequence DataNeoplasm StagingOncogene Proteins, ViralPapillomavirus E7 ProteinsSignal TransductionT-LymphocytesUterine Cervical NeoplasmsConceptsT cell epitopesCD4 T cell epitopesT cell responsesT cell clonesHPV 16T cell linesDose escalation phase I clinical trialPeripheral blood mononuclear cellsE7 proteinPositive T-cell responsesPhase I clinical trialAutologous mature DCDendritic cell vaccinationIIA cervical cancerCervical cancer patientsIFN-γ secretionBlood mononuclear cellsHuman papillomavirus type 16Papillomavirus type 16Cell vaccinationStage IBDendritic cellsMature DCsCervical cancerELISPOT assay
1999
Expression of Surface Antigens During the Differentiation of Human Dendritic Cells vs Macrophages from Blood Monocytes in vitro
Santin A, Hermonat P, Ravaggi M, Chiriva-Internat M, Cannon M, Hiserodt J, Pecorell S, Parham G. Expression of Surface Antigens During the Differentiation of Human Dendritic Cells vs Macrophages from Blood Monocytes in vitro. Immunobiology 1999, 200: 187-204. PMID: 10416127, DOI: 10.1016/s0171-2985(99)80069-2.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDAntigens, CD1Antigens, SurfaceB7-1 AntigenB7-2 AntigenCD40 AntigensCD58 AntigensCell AdhesionCell DifferentiationCell DivisionCells, CulturedDendritic CellsGranulocyte-Macrophage Colony-Stimulating FactorHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansImmunoglobulinsImmunophenotypingIntercellular Adhesion Molecule-1Interleukin-4Leukocytes, MononuclearLipopolysaccharide ReceptorsMacrophagesMembrane GlycoproteinsMonocytesT-LymphocytesConceptsDendritic cellsICAM-1 expressionMHC class IIBlood monocytesCostimulation moleculesDay 3Day 10MHC antigensCD14 expressionICAM-1Day 5Majority of DCNaive T cell primingClass IIDifferentiation of DCsProfessional antigen presenting cellsT cell primingHuman dendritic cellsMHC class II moleculesAntigen presenting cellsGM-CSF/ILClass II moleculesMHC class IImportant surface moleculesEarly time points
1998
Retinoic acid up-regulates the expression of major histocompatibility complex molecules and adhesion/costimulation molecules (specifically, intercellular adhesion molecule ICAM-1) in human cervical cancer
Santin A, Hermonat P, Ravaggi A, Chiriva-Internati M, Pecorelli S, Parham G. Retinoic acid up-regulates the expression of major histocompatibility complex molecules and adhesion/costimulation molecules (specifically, intercellular adhesion molecule ICAM-1) in human cervical cancer. American Journal Of Obstetrics And Gynecology 1998, 179: 1020-1025. PMID: 9790391, DOI: 10.1016/s0002-9378(98)70209-1.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, NorthernFemaleFlow CytometryFluorescent Antibody Technique, IndirectGene Expression Regulation, NeoplasticHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansIntercellular Adhesion Molecule-1RNA, MessengerTretinoinTumor Cells, CulturedUterine Cervical NeoplasmsConceptsMajor histocompatibility complex class IHistocompatibility complex class IComplex class IICAM-1 antigenCervical cancerCervical carcinoma cell linesSurface antigenClass IHuman cervical carcinoma cell lineRetinoic acidCarcinoma cell linesTherapeutic dosesHuman leukocyte antigen (HLA) class IClass II surface antigensCell linesAdhesion molecules ICAM-1Fluorescence-activated cell sorter analysisIntercellular adhesion molecule ICAM-1Additional clinical researchHuman leukocyte antigenMajor histocompatibility complex moleculesAntigen class IMolecules ICAM-1Use of retinoidsUntreated tumor cellsEffects of Retinoic Acid Combined with Irradiation on the Expression of Major Histocompatibility Complex Molecules and Adhesion/Costimulation Molecules ICAM-1 in Human Cervical Cancer
Santin A, Hermonat P, Ravaggi A, Chiriva-Internati M, Hiserodt J, Pecorelli S, Parham G. Effects of Retinoic Acid Combined with Irradiation on the Expression of Major Histocompatibility Complex Molecules and Adhesion/Costimulation Molecules ICAM-1 in Human Cervical Cancer. Gynecologic Oncology 1998, 70: 195-201. PMID: 9740690, DOI: 10.1006/gyno.1998.5060.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsFemaleHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansIntercellular Adhesion Molecule-1Radiation DosageTretinoinTumor Cells, CulturedUterine Cervical NeoplasmsConceptsIntercellular adhesion molecule-1Class II surface antigensICAM-1 antigenSurface antigenMHC class ICervical cancer cellsClass IRetinoic acidCervical cancerHigh dosesUpregulated HLA class ITumor cellsSiHa cervical cancer cellsMajor histocompatibility complex class ICancer cellsHistocompatibility complex class IMajor histocompatibility complex moleculesMolecules ICAM-1Adhesion molecule-1HLA class IICAM-1 moleculesUntreated tumor cellsHuman cervical cancerCervical cancer therapyComplex class I
1997
Effects of irradiation on the expression of major histocompatibility complex class I antigen and adhesion costimulation molecules ICAM-1 in human cervical cancer
Santin A, Hermonat P, Hiserodt J, Chiriva-Internati M, Woodliff J, Theus J, Barclay D, Pecorelli S, Parham G. Effects of irradiation on the expression of major histocompatibility complex class I antigen and adhesion costimulation molecules ICAM-1 in human cervical cancer. International Journal Of Radiation Oncology • Biology • Physics 1997, 39: 737-742. PMID: 9336157, DOI: 10.1016/s0360-3016(97)00372-6.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, NeoplasmDose Fractionation, RadiationFemaleHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansIntercellular Adhesion Molecule-1Tumor Cells, CulturedUp-RegulationUterine Cervical NeoplasmsConceptsMHC class ISurface antigenClass IAntigen expressionICAM-1High dosesClass II surface antigensCell linesSiHa cervical cancer cellsMajor histocompatibility complex class IHistocompatibility complex class IICAM-1 antigenMolecules ICAM-1Cell replicationSurface antigen expressionHuman cervical cancerComplex class ICervical cancer cellsCervical carcinoma cell linesCervical cell linesHuman cervical carcinoma cell lineDifferent time pointsCervical cancerCarcinoma cell linesHigh radiation doses
1996
Development and characterization of a clinically useful animal model of epithelial ovarian cancer in the Fischer 344 rat
Government. T, Rose, Tocco, Granger, DiSaia, Hamilton, Santin, Hiserodt. Development and characterization of a clinically useful animal model of epithelial ovarian cancer in the Fischer 344 rat. American Journal Of Obstetrics And Gynecology 1996, 175: 593-599. PMID: 8828419, DOI: 10.1053/ob.1996.v175.a73595.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAnimalsDisease Models, AnimalEpitheliumFemaleFlow CytometryHistocompatibility Antigens Class IHistocompatibility Antigens Class IIInjections, IntraperitonealIntercellular Adhesion Molecule-1MiceMice, NudeNeoplasm TransplantationOvarian NeoplasmsRatsRats, Inbred F344Tumor Cells, CulturedConceptsNuTu-19 cellsMajor histocompatibility complex class IEpithelial ovarian cancerHistocompatibility complex class IFischer 344 ratsComplex class IOvarian cancerCell surface antigensAnimal modelsAnimal survivalSurface antigenMajor histocompatibility complex class II antigensOvarian cancer animal modelKaplan-Meier survival analysisHuman ovarian epithelial carcinomaTumor cellsCell linesClass IClass II antigensExperimental animal modelsViable tumor cellsFemale athymic miceOvarian epithelial carcinomaParental tumor cellsUseful animal model