The utility and limitations of B- and T-cell gene rearrangement studies in evaluating lymphoproliferative disorders
Mendoza H, Tormey CA, Rinder HM, Howe JG, Siddon AJ. The utility and limitations of B- and T-cell gene rearrangement studies in evaluating lymphoproliferative disorders. Pathology 2020, 53: 157-165. PMID: 33358756, DOI: 10.1016/j.pathol.2020.09.024.Peer-Reviewed Original ResearchConceptsTCR gene rearrangement analysisGene rearrangement analysisPolymerase chain reactionRearrangement analysisLymphocyte populationsLymphoid malignanciesT-cell receptor gene rearrangement analysisT-cell gene rearrangement studiesTCR gene rearrangement patternsT cell populationsGene rearrangement studiesNext-generation sequencingGene rearrangement patternsLymphoproliferative disordersCharacterization of circulating and cultured Tfh-like cells in sickle cell disease in relation to red blood cell alloimmunization status
Balbuena-Merle R, Santhanakrishnan M, Devine L, Gibb DR, Tormey CA, Siddon AJ, Curtis SA, Gallagher PG, Weinstein JS, Hendrickson JE. Characterization of circulating and cultured Tfh-like cells in sickle cell disease in relation to red blood cell alloimmunization status. Transfusion And Apheresis Science 2020, 59: 102778. PMID: 32439490, PMCID: PMC7483805, DOI: 10.1016/j.transci.2020.102778.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemia, Sickle CellErythrocyte TransfusionFemaleHumansMaleT-Lymphocyte SubsetsTransfusion MedicineConceptsTfh-like cellsNaïve CD4 T cellsSickle cell diseaseCD4 T cellsCD4 T cell subsetsT cell subsetsT cellsCell diseaseRed blood cell alloimmunizationPeripheral blood mononuclear cellsBlood mononuclear cellsCD3/CD28Electronic medical recordsAlloimmunization statusHLA alloantibodiesRBC autoantibodiesRBC alloantibodiesFollicular helperIL-12Mononuclear cellsMedical recordsIL-7Antigen specificityB cellsAlloantibodies