2010
An Implantable Vascularized Protein Gel Construct That Supports Human Fetal Hepatoblast Survival and Infection by Hepatitis C Virus in Mice
Harding MJ, Lepus CM, Gibson TF, Shepherd BR, Gerber SA, Graham M, Paturzo FX, Rahner C, Madri JA, Bothwell AL, Lindenbach BD, Pober JS. An Implantable Vascularized Protein Gel Construct That Supports Human Fetal Hepatoblast Survival and Infection by Hepatitis C Virus in Mice. PLOS ONE 2010, 5: e9987. PMID: 20376322, PMCID: PMC2848675, DOI: 10.1371/journal.pone.0009987.Peer-Reviewed Original ResearchConceptsHepatitis C virusHuman fetal hepatoblastsSmall animal modelsC virusAnimal modelsAccessible small animal modelsHuh-7.5 hepatoma cellsRobust small animal modelHuman hepatocyte engraftmentHuman albumin levelsBcl-2-transduced human umbilical vein endothelial cellsHuman umbilical vein endothelial cellsHepatocyte growth factorUmbilical vein endothelial cellsHCV infectionVein endothelial cellsAlbumin levelsHepatocyte engraftmentBeige miceImmunodeficient miceHistological appearanceImmunoelectron microscopic analysisMRNA expressionViral adsorptionHepatic epithelial cells
2004
Bcl-2 Transduction Protects Human Endothelial Cell Synthetic Microvessel Grafts from Allogeneic T Cells In Vivo
Zheng L, Gibson TF, Schechner JS, Pober JS, Bothwell AL. Bcl-2 Transduction Protects Human Endothelial Cell Synthetic Microvessel Grafts from Allogeneic T Cells In Vivo. The Journal Of Immunology 2004, 173: 3020-3026. PMID: 15322161, DOI: 10.4049/jimmunol.173.5.3020.Peer-Reviewed Original ResearchConceptsEndothelial cellsAllogeneic T cellsT cell responsesHuman immune responseT cell interactionsVascular endothelial cellsHuman T lymphocytesGraft infiltrationAdoptive transferAllograft rejectionImmune surveillanceT cellsT lymphocytesImmune responseImmunological functionsMurine modelAnimal modelsVivo findingsCell responsesMicrovascular bedBcl-2 proteinPathological processesGraftCell interactionsCells