Pivotal roles of CD8+ T cells restricted by MHC class I–like molecules in autoimmune diseases
Das G, Das J, Eynott P, Zhang Y, Bothwell AL, Van Kaer L, Shi Y. Pivotal roles of CD8+ T cells restricted by MHC class I–like molecules in autoimmune diseases. Journal Of Experimental Medicine 2006, 203: 2603-2611. PMID: 17088432, PMCID: PMC2118151, DOI: 10.1084/jem.20060936.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmune DiseasesBeta 2-MicroglobulinCD8-Positive T-LymphocytesCell SurvivalFemaleH-2 AntigensHistocompatibility Antigen H-2DHistocompatibility Antigens Class IIInflammatory Bowel DiseasesIslets of LangerhansLymphoproliferative DisordersMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNuclear ProteinsTrans-ActivatorsConceptsInnate-like lymphocytesInflammatory bowel diseaseMHC class IT cellsAutoimmune diseasesClass IMajor histocompatibility complex class IaLike moleculesClass II moleculesAdoptive transferBowel diseaseAutoimmune disordersLymphoproliferative syndromeImmunoregulatory functionsAdaptive immunityCD8Class IaDiseaseMiceInsulitisAutoimmunityPivotal roleCellsLymphocytesSyndromeThe mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells
Chae WJ, Henegariu O, Lee SK, Bothwell AL. The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 9631-9636. PMID: 16769892, PMCID: PMC1480458, DOI: 10.1073/pnas.0600225103.Peer-Reviewed Original ResearchConceptsWild-type FOXP3Regulatory T cellsCD4 T cellsT cellsAutoimmune diseasesTh2-type cytokine secretionScurfy mutant mouseSevere autoimmune diseaseFoxp3 transcription factorAntigenic stimulationCytokine secretionFoxp3Suppressive functionMutant miceAdhesion moleculesSuppressor activityDiseaseGlutamic acidImportant roleCellsCD103HyporesponsivenessTh1Leucine zipper domainTranscription factors