2006
Manganese Treatment Modulates the Expression of Peroxisome Proliferator-activated Receptors in Astrocytoma and Neuroblastoma Cells
Isaac AO, Kawikova I, Bothwell AL, Daniels CK, Lai JC. Manganese Treatment Modulates the Expression of Peroxisome Proliferator-activated Receptors in Astrocytoma and Neuroblastoma Cells. Neurochemical Research 2006, 31: 1305-1316. PMID: 17053972, DOI: 10.1007/s11064-006-9173-0.Peer-Reviewed Original ResearchConceptsPeroxisome proliferator-activated receptorMn neurotoxicityPPAR isoformsExpression of PPARsNeuroblastoma cellsProliferator-activated receptorAnti-oxidant responseCell typesChronic exposureNeurotoxic mechanismsPeroxisome proliferatorPathophysiological importanceHuman astrocytomasNeural cellsNeurotoxicityManganese chloride treatmentProtein expressionCell proliferationAstrocytomasManganese treatmentReceptorsMolecular mechanismsTreatmentCytosolic fractionCells
2002
Cutting Edge: Internalization of Transduced E-Selectin by Cultured Human Endothelial Cells: Comparison of Dermal Microvascular and Umbilical Vein Cells and Identification of a Phosphoserine-Type Di-leucine Motif
Kluger MS, Shiao SL, Bothwell AL, Pober JS. Cutting Edge: Internalization of Transduced E-Selectin by Cultured Human Endothelial Cells: Comparison of Dermal Microvascular and Umbilical Vein Cells and Identification of a Phosphoserine-Type Di-leucine Motif. The Journal Of Immunology 2002, 168: 2091-2095. PMID: 11859093, DOI: 10.4049/jimmunol.168.5.2091.Peer-Reviewed Original ResearchConceptsHuman dermal microvascular endothelial cellsRate of internalizationAspartic acid substitutionSurface protein expressionEndothelial cell behaviorLeucine motifProtein internalizationCytoplasmic regionSurface expression levelsType motifSelectin surface expressionEndothelial cellsMutational analysisHuman endothelial cellsUmbilical vein cellsAcid substitutionsDermal microvascular endothelial cellsCell behaviorCultured human endothelial cellsCytokine inductionExpression levelsVein cellsInternalization processProtein expressionMotif