2007
Regulatory Transplantation Tolerance and “Stemness”: Evidence That Foxp3 May Play a Regulatory Role in SOCS-3 Gene Transcription
Muthukumarana P, Chae WJ, Maher S, Rosengard BR, Bothwell AL, Metcalfe SM. Regulatory Transplantation Tolerance and “Stemness”: Evidence That Foxp3 May Play a Regulatory Role in SOCS-3 Gene Transcription. Transplantation 2007, 84: s6-s11. PMID: 17632414, DOI: 10.1097/01.tp.0000269116.06510.db.Peer-Reviewed Original ResearchConceptsExpression of Foxp3Wt-Foxp3Regulatory transplantation toleranceSOCS-3Immune effector cellsStem cell-related factorsHuman T cell lineCell-related factorsT cell linesJurkat human T cell lineSOCS-3 transcriptsLIF transcriptionSuppressor of cytokineTransplantation toleranceEffector cellsT lymphocytesFoxp3Inhibitory factorKey mediatorT cell signal transductionAxotrophinTregsFurther evidenceTranscriptional activityRegulatory role
2004
Inhibition of alloresponse by a human trophoblast non-coding RNA suppressing class II transactivator promoter III and major histocompatibility class II expression in murine B-lymphocytes
Geirsson A, Bothwell AL, Hammond GL. Inhibition of alloresponse by a human trophoblast non-coding RNA suppressing class II transactivator promoter III and major histocompatibility class II expression in murine B-lymphocytes. The Journal Of Heart And Lung Transplantation 2004, 23: 1077-1081. PMID: 15454174, DOI: 10.1016/j.healun.2004.07.020.Peer-Reviewed Original ResearchConceptsClass II expressionCIITA promoter IIIPromoter IIIMajor histocompatibilityClass II transactivator promoter IIIMajor histocompatibility class II expressionMHC class II expressionConstitutive class II expressionClass II transcriptsAllograft toleranceLymphocyte proliferationT lymphocytesAllogenic responseLymphocyte stimulationMurine B lymphocytesB cellsB lymphocytesClass IIFlow cytometryFunctional affectsConcurrent suppressionBp 152AlloresponseSignificant suppressionCIITA promoterBcl-2 Transduction Protects Human Endothelial Cell Synthetic Microvessel Grafts from Allogeneic T Cells In Vivo
Zheng L, Gibson TF, Schechner JS, Pober JS, Bothwell AL. Bcl-2 Transduction Protects Human Endothelial Cell Synthetic Microvessel Grafts from Allogeneic T Cells In Vivo. The Journal Of Immunology 2004, 173: 3020-3026. PMID: 15322161, DOI: 10.4049/jimmunol.173.5.3020.Peer-Reviewed Original ResearchConceptsEndothelial cellsAllogeneic T cellsT cell responsesHuman immune responseT cell interactionsVascular endothelial cellsHuman T lymphocytesGraft infiltrationAdoptive transferAllograft rejectionImmune surveillanceT cellsT lymphocytesImmune responseImmunological functionsMurine modelAnimal modelsVivo findingsCell responsesMicrovascular bedBcl-2 proteinPathological processesGraftCell interactionsCells