2010
Cell-permeable Foxp3 protein alleviates autoimmune disease associated with inflammatory bowel disease and allergic airway inflammation
Choi JM, Shin JH, Sohn MH, Harding MJ, Park JH, Tobiasova Z, Kim DY, Maher SE, Chae WJ, Park SH, Lee CG, Lee SK, Bothwell AL. Cell-permeable Foxp3 protein alleviates autoimmune disease associated with inflammatory bowel disease and allergic airway inflammation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 18575-18580. PMID: 20937878, PMCID: PMC2972952, DOI: 10.1073/pnas.1000400107.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAsthmaAutoimmune DiseasesCell Membrane PermeabilityDisease Models, AnimalFemaleForkhead Transcription FactorsHumansInflammatory Bowel DiseasesLymphocyte ActivationMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMice, Mutant StrainsRecombinant Fusion ProteinsT-Lymphocytes, RegulatoryConceptsAllergic airway inflammationT cellsAirway inflammationAllergic diseasesFOXP3 proteinOvalbumin-induced allergic airway inflammationWild-type CD4 T cellsAllergic disease modelsDevelopment of colitisInflammatory bowel diseaseRegulatory T cellsCD4 T cellsInflammatory immune responseT cell activationFoxP3 transductionBowel diseaseScurfy miceTreg functionAutoimmune diseasesAutoimmune symptomsIntranasal deliveryTherapeutic effectImmune responseSystemic deliveryClinical potential
2002
Ly-6 Superfamily Members Ly-6A/E, Ly-6C, and Ly-6I Recognize Two Potential Ligands Expressed by B Lymphocytes
Pflugh DL, Maher SE, Bothwell AL. Ly-6 Superfamily Members Ly-6A/E, Ly-6C, and Ly-6I Recognize Two Potential Ligands Expressed by B Lymphocytes. The Journal Of Immunology 2002, 169: 5130-5136. PMID: 12391229, DOI: 10.4049/jimmunol.169.9.5130.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, B-LymphocyteAntigens, LyB-Lymphocyte SubsetsCD59 AntigensCell Adhesion MoleculesCHO CellsCOS CellsCricetinaeGenetic VariationImmunoglobulin Constant RegionsImmunoglobulin mu-ChainsLectinsLigandsMembrane ProteinsMiceMice, Inbred C57BLMultigene FamilyMyeloid CellsProtein BindingRecombinant Fusion ProteinsSialic Acid Binding Ig-like Lectin 2TransfectionTumor Cells, CulturedConceptsLy-6 proteinsLy-6A/EChimeric proteinLy-6 moleculesMost hemopoietic cellsGlycosylphosphatidylinositol-linked proteinsMature B cellsMembrane proteinsLipid raftsLy-6ECell adhesion moleculeStages of differentiationMature B lymphocytesAnalysis of variantsIgM heavy chainSupergene familyCH27 cellsProteinHemopoietic cellsLigand activityLy-6CHeavy chainPotential ligandsB lymphocytesAdhesion molecules