2004
Qualitatively differential regulation of T cell activation and apoptosis by T cell receptor ζ chain ITAMs and their tyrosine residues
Chae WJ, Lee HK, Han JH, Kim SW, Bothwell AL, Morio T, Lee SK. Qualitatively differential regulation of T cell activation and apoptosis by T cell receptor ζ chain ITAMs and their tyrosine residues. International Immunology 2004, 16: 1225-1236. PMID: 15302845, DOI: 10.1093/intimm/dxh120.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseTCR zeta chainTyrosine phosphorylated proteinsTyrosine residuesZeta chainPhosphorylated proteinsT cell activationCell deathFirst tyrosine residueCell activationInfluence of mutationsActivation-induced cell deathProtein kinaseDistinctive regulationIntracellular signalsDifferential regulationITAMMAPK phosphorylationTCR stimulationStepwise deletionJurkat transfectantsDistinct signalsActivation signalsMutationsResidues
2003
Receptor Activator of NF-κB Ligand Stimulates Recruitment of SHP-1 to the Complex Containing TNFR-Associated Factor 6 That Regulates Osteoclastogenesis
Zhang Z, Jimi E, Bothwell AL. Receptor Activator of NF-κB Ligand Stimulates Recruitment of SHP-1 to the Complex Containing TNFR-Associated Factor 6 That Regulates Osteoclastogenesis. The Journal Of Immunology 2003, 171: 3620-3626. PMID: 14500659, DOI: 10.4049/jimmunol.171.7.3620.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCell DifferentiationCell LineCysteineGenetic VectorsGlycoproteinsIntracellular Signaling Peptides and ProteinsLigandsMacrophagesMembrane GlycoproteinsMiceMice, Inbred C57BLMice, Mutant StrainsNF-kappa BOsteoclastsOsteoprotegerinPhosphatidylinositol 3-KinasesPhosphorylationProtein Phosphatase 1Protein Serine-Threonine KinasesProtein SubunitsProtein TransportProtein Tyrosine Phosphatase, Non-Receptor Type 6Protein Tyrosine PhosphatasesProteinsProto-Oncogene ProteinsProto-Oncogene Proteins c-aktRANK LigandReceptor Activator of Nuclear Factor-kappa BReceptors, Cytoplasmic and NuclearReceptors, Tumor Necrosis FactorRetroviridaeSerineSrc Homology DomainsTNF Receptor-Associated Factor 6Transduction, GeneticTyrosineUp-RegulationConceptsSrc homology 2 domain-containing phosphatase 1Mitogen-activated protein kinaseExpression of SHPProtein kinaseBone marrow macrophagesSrc homology 2 domainTyrosine phosphatase SHP-1P38 mitogen-activated protein kinaseExtracellular signal-regulated kinaseC-Jun N-terminal kinasePhosphatase SHP-1Phosphatidylinositol-3 kinaseMarrow macrophagesAssociation of TRAF6Signal-regulated kinaseN-terminal kinaseMultinuclear osteoclast-like cellsPhosphorylation of AktP85 subunitPhosphatase 1Tyrosine phosphorylationPathways downstreamRANKL-induced phosphorylationRAW264.7 cellsKinase
2002
Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction
Shim JH, Lee HK, Chang EJ, Chae WJ, Han JH, Han DJ, Morio T, Yang JJ, Bothwell A, Lee SK. Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 10617-10622. PMID: 12149481, PMCID: PMC124991, DOI: 10.1073/pnas.162522099.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntifungal AgentsApoptosisCaspase 3Caspase 9CaspasesCell DivisionCyclosporineFuransHeart TransplantationHeLa CellsHumansImmunosuppressive AgentsJurkat CellsLipidsLymphocyte ActivationMolecular StructurePhosphorylationPoly(ADP-ribose) PolymerasesProto-Oncogene Proteins c-bcl-2RatsRats, Inbred LewRats, WistarReceptor-CD3 Complex, Antigen, T-CellSignal TransductionT-LymphocytesTyrosine