2006
Decreased Numbers of Regulatory T Cells Suggest Impaired Immune Tolerance in Children with Tourette Syndrome: A Preliminary Study
Kawikova I, Leckman JF, Kronig H, Katsovich L, Bessen DE, Ghebremichael M, Bothwell AL. Decreased Numbers of Regulatory T Cells Suggest Impaired Immune Tolerance in Children with Tourette Syndrome: A Preliminary Study. Biological Psychiatry 2006, 61: 273-278. PMID: 16996487, DOI: 10.1016/j.biopsych.2006.06.012.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge of OnsetAntigens, CDAntigens, Differentiation, T-LymphocyteAutoantigensBlood Cell CountCD4 Lymphocyte CountCD8-Positive T-LymphocytesChildData Interpretation, StatisticalFemaleFlow CytometryHumansImmune ToleranceInterleukin-2 Receptor alpha SubunitLectins, C-TypeLymphocyte CountMaleStreptococcal InfectionsT-LymphocytesTic DisordersTourette SyndromeConceptsT reg cellsRegulatory T cellsReg cellsTourette syndromeT cellsTS patientsFluorescence-activated cell sortingHealthy age-matched control childrenHealthy age-matched control subjectsT reg cell numbersBeta-hemolytic streptococcal infectionAge-matched control subjectsHost T-cell immunityPathogenesis of TSHemolytic streptococcal infectionT cell immunitySignificant decreaseAge-matched control childrenAutoimmune inflammationCell immunityStreptococcal infectionAutoreactive lymphocytesImmune toleranceAutoimmune responsePeripheral blood
2004
Evidence for a dual pathway of activation in CD43-stimulated Th2 cells: differential requirement for the Lck tyrosine kinase
Fernandez-Cabezudo MJ, Vijayasarathy C, Pflugh DL, Bothwell AL, al-Ramadi BK. Evidence for a dual pathway of activation in CD43-stimulated Th2 cells: differential requirement for the Lck tyrosine kinase. International Immunology 2004, 16: 1215-1223. PMID: 15237112, DOI: 10.1093/intimm/dxh124.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteClone CellsHumansInterleukin-4Lectins, C-TypeLeukosialinLymphocyte ActivationLymphocyte Specific Protein Tyrosine Kinase p56(lck)MiceMultiprotein ComplexesPhosphoproteinsPhosphorylationReceptors, Interleukin-2Shc Signaling Adaptor ProteinsSialoglycoproteinsSignal TransductionSrc Homology 2 Domain-Containing, Transforming Protein 1Th2 CellsConceptsCD43 ligationSLP-76Adaptor protein SLP-76Tyrosine kinaseLck-deficient cellsTyrosine phosphorylated proteinsLck tyrosine kinaseMulti-component complexesT cell biologyNaive splenic T cellsPhosphorylated proteinsMajor protein bandsTyrosine phosphorylationCell biologyPathway componentsDifferential requirementExact functionDifferent effector functionsPhosphorylationT cell moleculesCellular proliferationProtein bandsCell moleculesLckKinase