2024
Impact of luteoma during pregnancy on fetal development and its long-term effects into adulthood
Mavrantoni I, Borneman R, Hittelman A, Vash-Margita A. Impact of luteoma during pregnancy on fetal development and its long-term effects into adulthood. BMJ Case Reports 2024, 17: e259373. PMID: 39117365, DOI: 10.1136/bcr-2023-259373.Peer-Reviewed Original ResearchConceptsVaginal stenosisClinical follow-upTime of birthDilator usePosterior vaginoplastyAcademic medical centreTertiary care academic medical centreFetal developmentElevated androgensFollow-upMedical historyPenetrative intercourseMedical CentreLong-term effectsLuteomaLaboratory investigationsVaginoplastyPregnancyVaginaStenosisPatientsPsychosocial implicationsVirilisationCystoscopyIntroitus
2023
Surgical Correction of Vaginal Agenesis via Modified Laparoscopic Vecchietti Procedure
Esencan E, St Martin B, Harmanli O, Vash-Margita A. Surgical Correction of Vaginal Agenesis via Modified Laparoscopic Vecchietti Procedure. Journal Of Pediatric And Adolescent Gynecology 2023, 36: 556-559. PMID: 37354985, DOI: 10.1016/j.jpag.2023.06.004.Peer-Reviewed Original ResearchConceptsLaparoscopic Vecchietti procedureVecchietti procedureVaginal dilationVaginal agenesisSurgical correctionRudimentary uterine hornExtensive counselingMayer-RokitanskyNormal ovariesSuture adjustmentPrimary amenorrheaSecondary sex characteristicsUterine hornVaginal canalAgenesisSex characteristicsType IDilationUnsuccessful attemptsAmenorrheaNeovaginaPatientsVaginoplastyMucosaGraftVaginal bleeding in a newborn as initial presentation of uterus didelphys
Saleh F, Gaeta M, Rost I, Vash-Margita A. Vaginal bleeding in a newborn as initial presentation of uterus didelphys. BMJ Case Reports 2023, 16: e251017. PMID: 36750302, PMCID: PMC9906268, DOI: 10.1136/bcr-2022-251017.Peer-Reviewed Original ResearchConceptsVaginal bleedingUterus didelphysTransabdominal ultrasoundHeavy vaginal bleedingAbnormal vaginal bleedingMüllerian anomaliesInitial presentationEndometrial tissueEstrogen levelsHeavy bleedingSurgical interventionUtero exposureAssociated conditionPostnatal periodBleedingBaby girlDidelphysNewbornsRoutine considerationNormal phenomenonUltrasoundNeonatesDiagnosis
2021
The Embryological Landscape of Mayer-Rokitansky-Kuster-Hauser Syndrome: Genetics and Environmental Factors.
Kyei-Barffour I, Margetts M, Vash-Margita A, Pelosi E. The Embryological Landscape of Mayer-Rokitansky-Kuster-Hauser Syndrome: Genetics and Environmental Factors. The Yale Journal Of Biology And Medicine 2021, 94: 657-672. PMID: 34970104, PMCID: PMC8686787.Peer-Reviewed Original ResearchConceptsMRKH syndromeClinical presentationMayer-RokitanskyEmbryonic developmentEnvironmental factorsEpigenetic changesFunctional validationCandidate genesGenetic analysisMolecular mechanismsDevelopmental pathwaysKüster-Hauser syndromeEarly organogenesisKuster-Hauser syndromeKey pathwaysGenetic componentInheritance patternEnvironmental compoundsIncomplete penetranceClinical managementDiscordant phenotypesEarly diagnosisAnimal modelsGeneticsTranslational studies
2020
Laparoscopic Colpo-Pneumo Occluder as a Vaginal Mold for Vaginal Reconstruction
Vash-Margita A, Mutlu L, Harmanli O. Laparoscopic Colpo-Pneumo Occluder as a Vaginal Mold for Vaginal Reconstruction. Journal Of Pediatric And Adolescent Gynecology 2020, 34: 80-83. PMID: 32781237, DOI: 10.1016/j.jpag.2020.08.002.Peer-Reviewed Original ResearchConceptsVaginal moldReconstructive surgeryVaginal anomaliesVaginal reconstructive surgeryTransverse vaginal septumCorrection of congenitalCongenital vaginal anomaliesRecurrent obstructionLaparoscopic hysterectomyPostoperative careVaginal surgeryVaginal septumVaginal reconstructionVaginal deviceSurgeryOccluderBalloonHysterectomyHematocolposPneumoperitoneumColpotomyCongenitalObstruction