2024
Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity
Slusher A, Nouws J, Tokoglu F, Vash‐Margita A, Matthews M, Fitch M, Shankaran M, Hellerstein M, Caprio S. Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity. Obesity 2024, 32: 593-602. PMID: 38410080, PMCID: PMC11034857, DOI: 10.1002/oby.23974.Peer-Reviewed Original ResearchConceptsSubcutaneous adipose tissueLiver fat contentInsulin resistanceInsulin sensitivityEctopic storage of lipidOral glucose tolerance testGluteal subcutaneous adipose tissueExtracellular matrix dynamicsMagnetic resonance imaging scansAdipose tissueBody fat distribution patternsFibrogenesis in vivoAdipocyte turnoverAssociated with insulin resistanceGlucose tolerance testFat distribution patternsWhole-body IRAdipose tissue insulin signalingTissue insulin signalingTolerance testGluteal fatImaging scansPathophysiological pathwaysAssociated with ratioObesity
2023
Vulvovaginal Complaints as the First Manifestation of Crohn's Disease in Children: Case Report
Brioso X, Banks D, Christison-Lagay E, Phatak U, Vash-Margita A. Vulvovaginal Complaints as the First Manifestation of Crohn's Disease in Children: Case Report. Journal Of Pediatric And Adolescent Gynecology 2023, 36: 494-496. PMID: 37196754, DOI: 10.1016/j.jpag.2023.05.007.Peer-Reviewed Original ResearchConceptsCrohn's diseasePediatric gynecologistImprovement of symptomsGastrointestinal inflammatory conditionsChronic constipationPrompt diagnosisPediatric populationVulvar irritationPremenarchal femalesVulvar complaintsCase reportInflammatory conditionsFirst manifestationVulvovaginal complaintsClear diagnosisHigh indexDiseaseDiagnosisFirst signAnatomical changesGynecologistsComplaintsTreatmentChildrenPoor growthVulvar Aphthous Ulcers in Perimenarchal Adolescents after COVID-19 Vaccination: A Multicenter Case Series
Sartor R, Lawson A, Moncada-Madrazo M, Altchek C, Vash-Margita A, Cron J. Vulvar Aphthous Ulcers in Perimenarchal Adolescents after COVID-19 Vaccination: A Multicenter Case Series. Journal Of Pediatric And Adolescent Gynecology 2023, 36: 268-272. PMID: 36708984, PMCID: PMC9876002, DOI: 10.1016/j.jpag.2023.01.003.Peer-Reviewed Original ResearchConceptsCOVID-19 vaccinationAphthous ulcersCase seriesMulticenter case seriesAdolescent gynecology serviceVulvar ulcersDiagnostic workupGynecology serviceTreatment modalitiesPatient presentationDifferential diagnosisClinical experienceUlcersVaccinationTemporal associationFemale adolescentsCOVID-19Novel associationsAdolescentsAssociationOverall coursePresentationComplicationsPatientsVaccine
2022
Evaluation of the Association of Endometrial Thickness, Insulin Resistance, and Menstrual Patterns in Adolescent Females with Polycystic Ovarian Syndrome
Lynn A, Solomon N, Zamani M, Rowe E, Seifer D, Vash-Margita A. Evaluation of the Association of Endometrial Thickness, Insulin Resistance, and Menstrual Patterns in Adolescent Females with Polycystic Ovarian Syndrome. Journal Of Pediatric And Adolescent Gynecology 2022, 36: 134-139. PMID: 36403727, DOI: 10.1016/j.jpag.2022.11.005.Peer-Reviewed Original ResearchConceptsPCOS groupInsulin resistanceMenstrual patternAdolescent femalesControl groupRetrospective case-control studyLarge-scale prospective studiesAcute pelvic painEndometrial stripe thicknessTransabdominal pelvic ultrasoundTertiary children's hospitalPolycystic ovarian syndromeBody mass indexCase-control studyInstitutional review boardAdolescent PCOSEndometrial thicknessPelvic painOvarian syndromePCOS diagnosisPelvic ultrasoundUnique pathophysiologyEndocrinology clinicChildren's HospitalMass indexEstablishing an Association between Polycystic Ovarian Syndrome and Pilonidal Disease in Adolescent Females
Adjei NN, Yung N, Towers G, Caty M, Solomon D, Vash-Margita A. Establishing an Association between Polycystic Ovarian Syndrome and Pilonidal Disease in Adolescent Females. Journal Of Pediatric And Adolescent Gynecology 2022, 36: 39-44. PMID: 35995086, DOI: 10.1016/j.jpag.2022.08.005.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromePilonidal diseaseBody mass indexAdolescent femalesRotterdam criteriaOvarian syndromeMass indexHospital participantsFeatures of PCOSTreatment of PCOSRetrospective cohort study SETTINGUrban tertiary medical centerHigher body mass indexCohort study SETTINGTertiary medical centerAdolescent medicine specialistsRace/ethnicityDisease courseMetabolic syndromePayer statusSerum markersPrevalence ratiosMedical CenterTobacco useMedicine specialistsSystematic Literature Review of Pediatric Male and Female Genital Hair Thread Tourniquet Syndrome
Adjei NN, Lynn AY, Grimshaw A, Brault MA, Dugan K, Vash-Margita A. Systematic Literature Review of Pediatric Male and Female Genital Hair Thread Tourniquet Syndrome. Pediatric Emergency Care 2022, 38: e799-e804. PMID: 35100779, DOI: 10.1097/pec.0000000000002383.Peer-Reviewed Original ResearchConceptsHair-thread tourniquet syndromeTourniquet syndromeAdolescent health care providersSystematic literature reviewHealth care providersEmergency medicine physiciansLiterature reviewUrinary symptomsSerious sequelaeAnesthetic typePrompt diagnosisFemale patientsGeneral anesthesiaAdolescent patientsFemale casesMale casesMAIN OUTCOMECare providersMedicine physiciansNational guidelinesAverage agePrevention strategiesPediatric malesLabia minoraPatient careMenstrual Health and Hygiene among Adolescents in the United States
Trant AA, Vash-Margita A, Camenga D, Braverman P, Wagner D, Espinal M, Kisanga EP, Lundsberg L, Sheth SS, Fan L. Menstrual Health and Hygiene among Adolescents in the United States. Journal Of Pediatric And Adolescent Gynecology 2022, 35: 277-287. PMID: 34999229, DOI: 10.1016/j.jpag.2021.12.014.Peer-Reviewed Original ResearchConceptsMenstrual health educationHealth educationSurvey response rateHealth careResponse rateMenstrual healthTertiary academic centerAdolescent medicine clinicMedicine clinicPatient interviewsPatient surveyGynecology practiceProvider surveyAcademic centersPatientsThematic saturationProvider perspectivesThematic content analysisProvider rolesAnonymous surveyCarePediatric facultyDescriptive statisticsMenstrual productsHealthThe SWIFT Model for Lichen Sclerosus Among Premenarchal Girls
Wang M, Wininger M, Vash-Margita A. The SWIFT Model for Lichen Sclerosus Among Premenarchal Girls. Journal Of Lower Genital Tract Disease 2022, 26: 46-52. PMID: 34928252, DOI: 10.1097/lgt.0000000000000634.Peer-Reviewed Original ResearchConceptsPremenarchal girlsLichen sclerosusLog oddsPilot studyAccurate risk stratificationRetrospective chart reviewAdolescent gynecology clinicUseful prognostic toolMajor academic centersPremenarchal patientsChart reviewUrinary incontinenceGynecology clinicRisk stratificationUnique patientsPatient populationSingle institutionVulvovaginal complaintsTimely diagnosisPrognostic toolAcademic centersClitoral hoodClinical diagnosisPatientsDiagnosis
2021
Multifaceted Approach to Evaluation in a Pediatric and Adolescent Gynecology Rotation for Medical Students
Solotke MT, Crabtree J, Cron J, Kallen A, Encandela J, Vash-Margita A. Multifaceted Approach to Evaluation in a Pediatric and Adolescent Gynecology Rotation for Medical Students. Journal Of Pediatric And Adolescent Gynecology 2021, 35: 270-276. PMID: 34906684, DOI: 10.1016/j.jpag.2021.12.006.Peer-Reviewed Original ResearchConceptsClinical knowledgeProspective pre-post studyClinical skillsPre-post studyEntrustable professional activitiesSignificant increaseT-testStudent's t-testClinical rotationsPost-rotation surveyMedical students' clinical skillsAdolescent gynecologyPilot studyCenter participantsMedical studentsStudents' clinical skillsMean pretest scoreGynecology rotationKnowledge/skill gapsMean posttest scoreFinal dayDescriptive statisticsSurvey settingsEntire populationScoresProgression of Cystadenoma to Mucinous Borderline Ovarian Tumor in Young Females: Case Series and Literature Review
Beroukhim G, Ozgediz D, Cohen PJ, Hui P, Morotti R, Schwartz PE, Yang-Hartwich, Vash-Margita A. Progression of Cystadenoma to Mucinous Borderline Ovarian Tumor in Young Females: Case Series and Literature Review. Journal Of Pediatric And Adolescent Gynecology 2021, 35: 359-367. PMID: 34843973, DOI: 10.1016/j.jpag.2021.11.003.Peer-Reviewed Original ResearchConceptsMucinous borderline ovarian tumorsBorderline ovarian tumorsOvarian tumorsYale-New Haven HospitalRetrospective chart reviewBenign ovarian tumorsBenign ovarian lesionsRate of recurrenceNew Haven HospitalAbdominal painPreoperative characteristicsChart reviewDisease recurrenceRecurrent cystsCase seriesChief complaintClinical presentationClinicopathologic featuresFemale patientsMucinous cystadenomaOvarian cystsOvarian lesionsTumor stageAdolescent patientsSubsequent surveillanceSupporting Patient-centered Communication on Adolescent Sexual and Reproductive Health—Perspectives to Build an Appointment Planning Tool
Brault MA, Curry LA, Kershaw T, Singh K, Vash-Margita A, Camenga D. Supporting Patient-centered Communication on Adolescent Sexual and Reproductive Health—Perspectives to Build an Appointment Planning Tool. Journal Of Pediatric And Adolescent Gynecology 2021, 34: 725-731. PMID: 33989800, PMCID: PMC10712738, DOI: 10.1016/j.jpag.2021.04.009.Peer-Reviewed Original ResearchConceptsSRH communicationAdolescent primary care clinicPatient/provider communicationAdolescent gynecology clinicPrimary care clinicsAdolescent girlsReproductive health perspectiveMobile health toolsPatient-centered carePatient-centered communicationFacilitators/barriersClinic visitsGynecology clinicCare clinicsSRH careProvider communicationClinic settingHolistic careContraceptive choicesHealthcare providersHealth toolsReproductive careCareAdolescent SexualHealth perspectiveMedically Indicated Labiaplasty in a Case of Recurrent Labial Hair Thread Tourniquet Syndrome in a Premenarchal Girl
Adjei N, Lynn A, Dugan K, Vash-Margita A. Medically Indicated Labiaplasty in a Case of Recurrent Labial Hair Thread Tourniquet Syndrome in a Premenarchal Girl. Journal Of Pediatric And Adolescent Gynecology 2021, 34: 761-763. PMID: 33839293, DOI: 10.1016/j.jpag.2021.03.007.Peer-Reviewed Original Research
2020
Characteristics Among Premenarchal Girls With Lichen Sclerosus.
Wang M, Arlen AM, Vash-Margita A. Characteristics Among Premenarchal Girls With Lichen Sclerosus. Journal Of Lower Genital Tract Disease 2020, 25: 152-157. PMID: 33284147, DOI: 10.1097/lgt.0000000000000584.Peer-Reviewed Original ResearchConceptsLower urinary tract symptomsResolution/improvementPremenarchal girlsRetrospective chart reviewUrinary tract symptomsChronic inflammatory dermatosisPediatric urology clinicPediatric–adolescent gynecologyPaucity of dataL symptomsLS symptomsLUTS symptomsVulvar LSBowel symptomsPostmenopausal womenTract symptomsVoiding symptomsChart reviewMedian ageLichen sclerosusClinical presentationUrology clinicInflammatory dermatosesLS diagnosisPrepubertal girlsLichen Sclerosus in Prepubertal Girls: An Uncommon but Treatable Cause of Lower Urinary Tract Symptoms
Arlen AM, Wang M, Vash-Margita A. Lichen Sclerosus in Prepubertal Girls: An Uncommon but Treatable Cause of Lower Urinary Tract Symptoms. Urology 2020, 137: e1-e2. PMID: 31917292, DOI: 10.1016/j.urology.2019.12.029.Peer-Reviewed Original ResearchConceptsLower urinary tract symptomsUrinary tract symptomsTract symptomsPrepubertal girlsChronic inflammatory dermatosisPediatric urology providersPostmenopausal womenTreatable causeAutoimmune conditionsLichen sclerosusTreatment delayInflammatory dermatosesSkin changesAtrophic patchesPerianal regionGenetic predispositionAnogenital regionUrology providersLack of familiaritySymptomsAge distributionGirlsIncontinenceSclerosusDermatoses
2019
Establishing a Pediatric and Adolescent Gynecology Subinternship for Medical Students
Solotke M, Crabtree J, Encandela J, Vash-Margita A. Establishing a Pediatric and Adolescent Gynecology Subinternship for Medical Students. Journal Of Pediatric And Adolescent Gynecology 2019, 33: 104-109. PMID: 31672667, DOI: 10.1016/j.jpag.2019.10.004.Peer-Reviewed Original ResearchConceptsMedical studentsYoung female patientMaternal-fetal medicineHealth care needsDelivery of careNorth American medical schoolsUndergraduate medical education levelTraining opportunitiesFemale patientsAdolescent patientsGynecologic oncologyAmerican medical schoolsMedical school levelSurgical opportunityMedical education levelCare needsClinical experienceGynecology communityFetal medicineInternal medicineSupervised clinical experienceLearning activitiesSchool levelElective courseFamily medicineThe complex relationship between urinary and defecatory disorders in young and adolescent girls.
Vash-Margita A, Guess MK. The complex relationship between urinary and defecatory disorders in young and adolescent girls. Current Opinion In Obstetrics & Gynecology 2019, 31: 317-324. PMID: 31361608, DOI: 10.1097/gco.0000000000000561.Peer-Reviewed Original ResearchConceptsBladder-bowel dysfunctionDefecatory disordersTreatment strategiesAdolescent girlsComplex pelvic floor disordersLower urinary tract dysfunctionAbnormal bowel habitsFunctional bowel disturbancesUrinary tract dysfunctionOptimal treatment strategyPelvic floor disordersUrinary tract pathologyComprehensive treatment strategyBowel disturbancesBowel habitsPerineal painBowel dysfunctionTract dysfunctionUrinary symptomsUrinary incontinenceTract pathologyPhysical examHealth burdenDisordersPathophysiologyA Rare and Extreme Case of Vulvar Swelling in the Setting of Nephrotic Syndrome in a Prepubertal Girl
Solotke MT, Soble W, Young C, Marsenic O, Vash-Margita A. A Rare and Extreme Case of Vulvar Swelling in the Setting of Nephrotic Syndrome in a Prepubertal Girl. Journal Of Pediatric And Adolescent Gynecology 2019, 33: 93-95. PMID: 31585165, DOI: 10.1016/j.jpag.2019.09.009.Peer-Reviewed Original Research