2024
Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity
Slusher A, Nouws J, Tokoglu F, Vash‐Margita A, Matthews M, Fitch M, Shankaran M, Hellerstein M, Caprio S. Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity. Obesity 2024, 32: 593-602. PMID: 38410080, PMCID: PMC11034857, DOI: 10.1002/oby.23974.Peer-Reviewed Original ResearchConceptsSubcutaneous adipose tissueLiver fat contentInsulin resistanceInsulin sensitivityEctopic storage of lipidOral glucose tolerance testGluteal subcutaneous adipose tissueExtracellular matrix dynamicsMagnetic resonance imaging scansAdipose tissueBody fat distribution patternsFibrogenesis in vivoAdipocyte turnoverAssociated with insulin resistanceGlucose tolerance testFat distribution patternsWhole-body IRAdipose tissue insulin signalingTissue insulin signalingTolerance testGluteal fatImaging scansPathophysiological pathwaysAssociated with ratioObesity
2023
Surgical Correction of Vaginal Agenesis via Modified Laparoscopic Vecchietti Procedure
Esencan E, St Martin B, Harmanli O, Vash-Margita A. Surgical Correction of Vaginal Agenesis via Modified Laparoscopic Vecchietti Procedure. Journal Of Pediatric And Adolescent Gynecology 2023, 36: 556-559. PMID: 37354985, DOI: 10.1016/j.jpag.2023.06.004.Peer-Reviewed Original ResearchConceptsLaparoscopic Vecchietti procedureVecchietti procedureVaginal dilationVaginal agenesisSurgical correctionRudimentary uterine hornExtensive counselingMayer-RokitanskyNormal ovariesSuture adjustmentPrimary amenorrheaSecondary sex characteristicsUterine hornVaginal canalAgenesisSex characteristicsType IDilationUnsuccessful attemptsAmenorrheaNeovaginaPatientsVaginoplastyMucosaGraftVulvar Aphthous Ulcers in Perimenarchal Adolescents after COVID-19 Vaccination: A Multicenter Case Series
Sartor R, Lawson A, Moncada-Madrazo M, Altchek C, Vash-Margita A, Cron J. Vulvar Aphthous Ulcers in Perimenarchal Adolescents after COVID-19 Vaccination: A Multicenter Case Series. Journal Of Pediatric And Adolescent Gynecology 2023, 36: 268-272. PMID: 36708984, PMCID: PMC9876002, DOI: 10.1016/j.jpag.2023.01.003.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildCOVID-19COVID-19 VaccinesFemaleHumansStomatitis, AphthousVaccinationVulvaConceptsCOVID-19 vaccinationAphthous ulcersCase seriesMulticenter case seriesAdolescent gynecology serviceVulvar ulcersDiagnostic workupGynecology serviceTreatment modalitiesPatient presentationDifferential diagnosisClinical experienceUlcersVaccinationTemporal associationFemale adolescentsCOVID-19Novel associationsAdolescentsAssociationOverall coursePresentationComplicationsPatientsVaccine
2022
Optimizing menstrual health and hygiene management in the U.S.: A mixed-methods study of the barriers and the role of healthcare professionals
Trant A, Espinal M, Kisanga E, Vash-Margita A, Lundsberg L, Sheth S, Fan L. Optimizing menstrual health and hygiene management in the U.S.: A mixed-methods study of the barriers and the role of healthcare professionals. Sexual & Reproductive Healthcare 2022, 35: 100808. PMID: 36563412, DOI: 10.1016/j.srhc.2022.100808.Peer-Reviewed Original ResearchConceptsResponse rateSurvey response rateThematic content analysisMH screeningPatient interviewsPatient surveyPatient understandingPatient's abilityPatientsHealthcare providersHealthcare professionalsHealth practicesMedical staffMenstrual productsStaff viewsDaily activitiesMixed-method studyMenstrual healthMenstruationDescriptive statisticsHealthHygiene managementScreeningAnnual incomeQualitative interviewsEvaluation of the Association of Endometrial Thickness, Insulin Resistance, and Menstrual Patterns in Adolescent Females with Polycystic Ovarian Syndrome
Lynn A, Solomon N, Zamani M, Rowe E, Seifer D, Vash-Margita A. Evaluation of the Association of Endometrial Thickness, Insulin Resistance, and Menstrual Patterns in Adolescent Females with Polycystic Ovarian Syndrome. Journal Of Pediatric And Adolescent Gynecology 2022, 36: 134-139. PMID: 36403727, DOI: 10.1016/j.jpag.2022.11.005.Peer-Reviewed Original ResearchConceptsPCOS groupInsulin resistanceMenstrual patternAdolescent femalesControl groupRetrospective case-control studyLarge-scale prospective studiesAcute pelvic painEndometrial stripe thicknessTransabdominal pelvic ultrasoundTertiary children's hospitalPolycystic ovarian syndromeBody mass indexCase-control studyInstitutional review boardAdolescent PCOSEndometrial thicknessPelvic painOvarian syndromePCOS diagnosisPelvic ultrasoundUnique pathophysiologyEndocrinology clinicChildren's HospitalMass indexEstablishing an Association between Polycystic Ovarian Syndrome and Pilonidal Disease in Adolescent Females
Adjei NN, Yung N, Towers G, Caty M, Solomon D, Vash-Margita A. Establishing an Association between Polycystic Ovarian Syndrome and Pilonidal Disease in Adolescent Females. Journal Of Pediatric And Adolescent Gynecology 2022, 36: 39-44. PMID: 35995086, DOI: 10.1016/j.jpag.2022.08.005.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromePilonidal diseaseBody mass indexAdolescent femalesRotterdam criteriaOvarian syndromeMass indexHospital participantsFeatures of PCOSTreatment of PCOSRetrospective cohort study SETTINGUrban tertiary medical centerHigher body mass indexCohort study SETTINGTertiary medical centerAdolescent medicine specialistsRace/ethnicityDisease courseMetabolic syndromePayer statusSerum markersPrevalence ratiosMedical CenterTobacco useMedicine specialistsMinimally Invasive Ovarian-Preserving Approach for the Management of a Sclerosing Stromal Tumor in an Adolescent: A Case Report
Ahuja C, Tymon-Rosario J, Rottmann D, Raad RA, Silasi DA, Vash-Margita A. Minimally Invasive Ovarian-Preserving Approach for the Management of a Sclerosing Stromal Tumor in an Adolescent: A Case Report. Journal Of Pediatric And Adolescent Gynecology 2022, 35: 505-508. PMID: 35123057, DOI: 10.1016/j.jpag.2022.01.008.Peer-Reviewed Original ResearchConceptsOvarian massesStromal tumorsRare benign ovarian tumorConstant abdominal painLeft ovarian massEvidence of malignancyBenign ovarian tumorsSclerosing Stromal TumorAbdominal painAbdominal massAbnormal findingsIntraoperative findingsSurgical findingsCystic massLeft adnexaOvarian tumorsCase reportLeft ovaryPhysical examPostpubertal femalesInvasive approachPelvis CTBenign natureAdolescent populationYoung adultsSystematic Literature Review of Pediatric Male and Female Genital Hair Thread Tourniquet Syndrome
Adjei NN, Lynn AY, Grimshaw A, Brault MA, Dugan K, Vash-Margita A. Systematic Literature Review of Pediatric Male and Female Genital Hair Thread Tourniquet Syndrome. Pediatric Emergency Care 2022, 38: e799-e804. PMID: 35100779, DOI: 10.1097/pec.0000000000002383.Peer-Reviewed Original ResearchConceptsHair-thread tourniquet syndromeTourniquet syndromeAdolescent health care providersSystematic literature reviewHealth care providersEmergency medicine physiciansLiterature reviewUrinary symptomsSerious sequelaeAnesthetic typePrompt diagnosisFemale patientsGeneral anesthesiaAdolescent patientsFemale casesMale casesMAIN OUTCOMECare providersMedicine physiciansNational guidelinesAverage agePrevention strategiesPediatric malesLabia minoraPatient careMenstrual Health and Hygiene among Adolescents in the United States
Trant AA, Vash-Margita A, Camenga D, Braverman P, Wagner D, Espinal M, Kisanga EP, Lundsberg L, Sheth SS, Fan L. Menstrual Health and Hygiene among Adolescents in the United States. Journal Of Pediatric And Adolescent Gynecology 2022, 35: 277-287. PMID: 34999229, DOI: 10.1016/j.jpag.2021.12.014.Peer-Reviewed Original ResearchConceptsMenstrual health educationHealth educationSurvey response rateHealth careResponse rateMenstrual healthTertiary academic centerAdolescent medicine clinicMedicine clinicPatient interviewsPatient surveyGynecology practiceProvider surveyAcademic centersPatientsThematic saturationProvider perspectivesThematic content analysisProvider rolesAnonymous surveyCarePediatric facultyDescriptive statisticsMenstrual productsHealthThe SWIFT Model for Lichen Sclerosus Among Premenarchal Girls
Wang M, Wininger M, Vash-Margita A. The SWIFT Model for Lichen Sclerosus Among Premenarchal Girls. Journal Of Lower Genital Tract Disease 2022, 26: 46-52. PMID: 34928252, DOI: 10.1097/lgt.0000000000000634.Peer-Reviewed Original ResearchConceptsPremenarchal girlsLichen sclerosusLog oddsPilot studyAccurate risk stratificationRetrospective chart reviewAdolescent gynecology clinicUseful prognostic toolMajor academic centersPremenarchal patientsChart reviewUrinary incontinenceGynecology clinicRisk stratificationUnique patientsPatient populationSingle institutionVulvovaginal complaintsTimely diagnosisPrognostic toolAcademic centersClitoral hoodClinical diagnosisPatientsDiagnosis
2021
Multifaceted Approach to Evaluation in a Pediatric and Adolescent Gynecology Rotation for Medical Students
Solotke MT, Crabtree J, Cron J, Kallen A, Encandela J, Vash-Margita A. Multifaceted Approach to Evaluation in a Pediatric and Adolescent Gynecology Rotation for Medical Students. Journal Of Pediatric And Adolescent Gynecology 2021, 35: 270-276. PMID: 34906684, DOI: 10.1016/j.jpag.2021.12.006.Peer-Reviewed Original ResearchConceptsClinical knowledgeProspective pre-post studyClinical skillsPre-post studyEntrustable professional activitiesSignificant increaseT-testStudent's t-testClinical rotationsPost-rotation surveyMedical students' clinical skillsAdolescent gynecologyPilot studyCenter participantsMedical studentsStudents' clinical skillsMean pretest scoreGynecology rotationKnowledge/skill gapsMean posttest scoreFinal dayDescriptive statisticsSurvey settingsEntire populationScoresProgression of Cystadenoma to Mucinous Borderline Ovarian Tumor in Young Females: Case Series and Literature Review
Beroukhim G, Ozgediz D, Cohen PJ, Hui P, Morotti R, Schwartz PE, Yang-Hartwich, Vash-Margita A. Progression of Cystadenoma to Mucinous Borderline Ovarian Tumor in Young Females: Case Series and Literature Review. Journal Of Pediatric And Adolescent Gynecology 2021, 35: 359-367. PMID: 34843973, DOI: 10.1016/j.jpag.2021.11.003.Peer-Reviewed Original ResearchConceptsMucinous borderline ovarian tumorsBorderline ovarian tumorsOvarian tumorsYale-New Haven HospitalRetrospective chart reviewBenign ovarian tumorsBenign ovarian lesionsRate of recurrenceNew Haven HospitalAbdominal painPreoperative characteristicsChart reviewDisease recurrenceRecurrent cystsCase seriesChief complaintClinical presentationClinicopathologic featuresFemale patientsMucinous cystadenomaOvarian cystsOvarian lesionsTumor stageAdolescent patientsSubsequent surveillanceCIDEA expression in SAT from adolescent girls with obesity and unfavorable patterns of abdominal fat distribution
Tarabra E, Nouws J, Vash‐Margita A, Hellerstein M, Shabanova V, McCollum S, Pierpont B, Zhao D, Shulman GI, Caprio S. CIDEA expression in SAT from adolescent girls with obesity and unfavorable patterns of abdominal fat distribution. Obesity 2021, 29: 2068-2080. PMID: 34672413, PMCID: PMC8612981, DOI: 10.1002/oby.23295.Peer-Reviewed Original ResearchConceptsAbdominal fat distributionVisceral adipose tissueCIDEA expressionFat distributionProtein levelsAbdominal SATAdolescent girlsHigher visceral adipose tissueSubcutaneous adipose tissue biopsiesAdipose tissue biopsiesReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionMagnetic resonance imagingWeight gain effectsExpression of CIDEAAdipocyte dysfunctionSAT biopsiesAdipose lipidsInsulin resistanceAdipocyte hypertrophySmall adipocytesAdipose tissueTissue biopsiesUnfavorable patternsStrong inverse correlationUnindicated cervical cancer screening in adolescent females within a large healthcare system in the United States
Hosier H, Sheth SS, Oliveira CR, Perley LE, Vash-Margita A. Unindicated cervical cancer screening in adolescent females within a large healthcare system in the United States. American Journal Of Obstetrics And Gynecology 2021, 225: 649.e1-649.e9. PMID: 34256029, PMCID: PMC8633062, DOI: 10.1016/j.ajog.2021.07.005.Peer-Reviewed Original ResearchConceptsCervical cancerLarge healthcare systemYears of ageIncidence rateScreening testAdolescent femalesHealthcare systemLarge multihospital health systemCervical cancer screening resultsNew cervical cancer casesCurrent consensus recommendationsHuman papillomavirus testingHuman papillomavirus vaccinationCervical cancer casesCervical cancer screeningMultihospital health systemCancer risk reductionScreening resultsPoisson regression analysisEvidence-based strategiesGuideline nonadherencePapillomavirus vaccinationCytology testingIntraepithelial lesionsProvider factorsSupporting Patient-centered Communication on Adolescent Sexual and Reproductive Health—Perspectives to Build an Appointment Planning Tool
Brault MA, Curry LA, Kershaw T, Singh K, Vash-Margita A, Camenga D. Supporting Patient-centered Communication on Adolescent Sexual and Reproductive Health—Perspectives to Build an Appointment Planning Tool. Journal Of Pediatric And Adolescent Gynecology 2021, 34: 725-731. PMID: 33989800, PMCID: PMC10712738, DOI: 10.1016/j.jpag.2021.04.009.Peer-Reviewed Original ResearchConceptsSRH communicationAdolescent primary care clinicPatient/provider communicationAdolescent gynecology clinicPrimary care clinicsAdolescent girlsReproductive health perspectiveMobile health toolsPatient-centered carePatient-centered communicationFacilitators/barriersClinic visitsGynecology clinicCare clinicsSRH careProvider communicationClinic settingHolistic careContraceptive choicesHealthcare providersHealth toolsReproductive careCareAdolescent SexualHealth perspectiveMedically Indicated Labiaplasty in a Case of Recurrent Labial Hair Thread Tourniquet Syndrome in a Premenarchal Girl
Adjei N, Lynn A, Dugan K, Vash-Margita A. Medically Indicated Labiaplasty in a Case of Recurrent Labial Hair Thread Tourniquet Syndrome in a Premenarchal Girl. Journal Of Pediatric And Adolescent Gynecology 2021, 34: 761-763. PMID: 33839293, DOI: 10.1016/j.jpag.2021.03.007.Peer-Reviewed Original ResearchNational Trends in Cervical Cancer Screening in Adolescents
Vash-Margita A, Kobernik EK, Flagler E, Quint EH, Dalton VK. National Trends in Cervical Cancer Screening in Adolescents. Journal Of Pediatric And Adolescent Gynecology 2021, 34: 717-724. PMID: 33601068, DOI: 10.1016/j.jpag.2021.02.097.Peer-Reviewed Original ResearchConceptsCervical cancer screeningCervical cancerCancer screeningAdolescents ages 14Women ages 14Office visitsAge 14Cervical cancer screening ratesMultivariable logistic regression modelPreventive care visitsRetrospective cohort studyCancer screening ratesOffice-based visitsObstetrician/gynecologistsLogistic regression modelsCare visitsCohort studyIndependent predictorsScreening ratesInsurance statusPatient educationProvider typeAmerican CollegeGynecology recommendationsAdolescent population
2020
Characteristics Among Premenarchal Girls With Lichen Sclerosus.
Wang M, Arlen AM, Vash-Margita A. Characteristics Among Premenarchal Girls With Lichen Sclerosus. Journal Of Lower Genital Tract Disease 2020, 25: 152-157. PMID: 33284147, DOI: 10.1097/lgt.0000000000000584.Peer-Reviewed Original ResearchConceptsLower urinary tract symptomsResolution/improvementPremenarchal girlsRetrospective chart reviewUrinary tract symptomsChronic inflammatory dermatosisPediatric urology clinicPediatric–adolescent gynecologyPaucity of dataL symptomsLS symptomsLUTS symptomsVulvar LSBowel symptomsPostmenopausal womenTract symptomsVoiding symptomsChart reviewMedian ageLichen sclerosusClinical presentationUrology clinicInflammatory dermatosesLS diagnosisPrepubertal girlsThe association between anti-Müllerian hormone and vitamin 25(OH)D serum levels and polycystic ovarian syndrome in adolescent females
Simpson S, Seifer DB, Shabanova V, Lynn AY, Howe C, Rowe E, Caprio S, Vash-Margita A. The association between anti-Müllerian hormone and vitamin 25(OH)D serum levels and polycystic ovarian syndrome in adolescent females. Reproductive Biology And Endocrinology 2020, 18: 118. PMID: 33218348, PMCID: PMC7679991, DOI: 10.1186/s12958-020-00676-y.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeRotterdam diagnostic criteriaNon-PCOS groupMedian AMHOvarian syndromePCOS groupDiagnostic criteriaAnti-Müllerian hormone levelsAdolescent femalesRetrospective chart reviewTraditional clinical markersAnti-Müllerian hormoneCross-sectional studyWilcoxon rank sum testSignificant unadjusted differencesRank sum testD deficiencyChart reviewClinical featuresEndocrinology clinicSerum levelsAdjusted analysisUnadjusted comparisonsInsurance typeSurrogate markerLaparoscopic Colpo-Pneumo Occluder as a Vaginal Mold for Vaginal Reconstruction
Vash-Margita A, Mutlu L, Harmanli O. Laparoscopic Colpo-Pneumo Occluder as a Vaginal Mold for Vaginal Reconstruction. Journal Of Pediatric And Adolescent Gynecology 2020, 34: 80-83. PMID: 32781237, DOI: 10.1016/j.jpag.2020.08.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentColpotomyFemaleHematocolposHumansLaparoscopyPlastic Surgery ProceduresPregnancyVaginaConceptsVaginal moldReconstructive surgeryVaginal anomaliesVaginal reconstructive surgeryTransverse vaginal septumCorrection of congenitalCongenital vaginal anomaliesRecurrent obstructionLaparoscopic hysterectomyPostoperative careVaginal surgeryVaginal septumVaginal reconstructionVaginal deviceSurgeryOccluderBalloonHysterectomyHematocolposPneumoperitoneumColpotomyCongenitalObstruction