2024
Impact of luteoma during pregnancy on fetal development and its long-term effects into adulthood
Mavrantoni I, Borneman R, Hittelman A, Vash-Margita A. Impact of luteoma during pregnancy on fetal development and its long-term effects into adulthood. BMJ Case Reports 2024, 17: e259373. PMID: 39117365, DOI: 10.1136/bcr-2023-259373.Peer-Reviewed Original ResearchConceptsVaginal stenosisClinical follow-upTime of birthDilator usePosterior vaginoplastyAcademic medical centreTertiary care academic medical centreFetal developmentElevated androgensFollow-upMedical historyPenetrative intercourseMedical CentreLong-term effectsLuteomaLaboratory investigationsVaginoplastyPregnancyVaginaStenosisPatientsPsychosocial implicationsVirilisationCystoscopyIntroitusAltered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity
Slusher A, Nouws J, Tokoglu F, Vash‐Margita A, Matthews M, Fitch M, Shankaran M, Hellerstein M, Caprio S. Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity. Obesity 2024, 32: 593-602. PMID: 38410080, PMCID: PMC11034857, DOI: 10.1002/oby.23974.Peer-Reviewed Original ResearchConceptsSubcutaneous adipose tissueLiver fat contentInsulin resistanceInsulin sensitivityEctopic storage of lipidOral glucose tolerance testGluteal subcutaneous adipose tissueExtracellular matrix dynamicsMagnetic resonance imaging scansAdipose tissueBody fat distribution patternsFibrogenesis in vivoAdipocyte turnoverAssociated with insulin resistanceGlucose tolerance testFat distribution patternsWhole-body IRAdipose tissue insulin signalingTissue insulin signalingTolerance testGluteal fatImaging scansPathophysiological pathwaysAssociated with ratioObesity
2023
The impact of the war in Ukraine on the reproductive health of female military personnel
Serbeniuk A, Kaminskiy V, Kumpanenko Y, Vash‐Margita A, Malysheva I. The impact of the war in Ukraine on the reproductive health of female military personnel. International Journal Of Gynecology & Obstetrics 2023, 163: 409-415. PMID: 37458251, DOI: 10.1002/ijgo.14990.Peer-Reviewed Original ResearchConceptsFemale military personnelLong menstrual periodsTimes higher likelihoodActive duty personnelMilitary personnelInfertility durationPainful menstruationPhysical examinationMedical historyMenstrual periodReproductive system pathologyHeavy periodsStructural pathologyPerinatal medicineSystem pathologyReproductive healthFemale veteransMental healthHealth declineLonger durationWomenHigher likelihoodConcussionPathologyTimes longer durationSurgical Correction of Vaginal Agenesis via Modified Laparoscopic Vecchietti Procedure
Esencan E, St Martin B, Harmanli O, Vash-Margita A. Surgical Correction of Vaginal Agenesis via Modified Laparoscopic Vecchietti Procedure. Journal Of Pediatric And Adolescent Gynecology 2023, 36: 556-559. PMID: 37354985, DOI: 10.1016/j.jpag.2023.06.004.Peer-Reviewed Original ResearchConceptsLaparoscopic Vecchietti procedureVecchietti procedureVaginal dilationVaginal agenesisSurgical correctionRudimentary uterine hornExtensive counselingMayer-RokitanskyNormal ovariesSuture adjustmentPrimary amenorrheaSecondary sex characteristicsUterine hornVaginal canalAgenesisSex characteristicsType IDilationUnsuccessful attemptsAmenorrheaNeovaginaPatientsVaginoplastyMucosaGraftPremenarchal lichen sclerosus: a multicentre examination of the novel diagnostic tool, the SWIFT model
Lawson A, Wininger M, Wang M, Steger M, Peccerillo K, Vash-Margita A. Premenarchal lichen sclerosus: a multicentre examination of the novel diagnostic tool, the SWIFT model. British Journal Of Dermatology 2023, 189: 353-354. PMID: 37235769, DOI: 10.1093/bjd/ljad180.Peer-Reviewed Original ResearchDiagnostic and surgical approaches to congenital uterine anomalies for the minimally invasive gynecologic surgeon
Murphy C, Wilcox A, Vash-Margita A. Diagnostic and surgical approaches to congenital uterine anomalies for the minimally invasive gynecologic surgeon. Current Opinion In Obstetrics & Gynecology 2023, 35: 328-336. PMID: 37266575, DOI: 10.1097/gco.0000000000000886.Peer-Reviewed Original ResearchConceptsCongenital uterine anomaliesUterine anomaliesGynecologic surgeonsInvasive gynecologic surgeonsInvasive surgical techniquesStandardized classification systemPerioperative considerationsSurgical approachSurgical techniqueClinical scenariosProvider useReproductive medicinePsychosocial wellbeingAmerican SocietySurgeonsTreatmentClassification systemPatientsReviewWorkupVulvovaginal Complaints as the First Manifestation of Crohn's Disease in Children: Case Report
Brioso X, Banks D, Christison-Lagay E, Phatak U, Vash-Margita A. Vulvovaginal Complaints as the First Manifestation of Crohn's Disease in Children: Case Report. Journal Of Pediatric And Adolescent Gynecology 2023, 36: 494-496. PMID: 37196754, DOI: 10.1016/j.jpag.2023.05.007.Peer-Reviewed Original ResearchConceptsCrohn's diseasePediatric gynecologistImprovement of symptomsGastrointestinal inflammatory conditionsChronic constipationPrompt diagnosisPediatric populationVulvar irritationPremenarchal femalesVulvar complaintsCase reportInflammatory conditionsFirst manifestationVulvovaginal complaintsClear diagnosisHigh indexDiseaseDiagnosisFirst signAnatomical changesGynecologistsComplaintsTreatmentChildrenPoor growthVaginal bleeding in a newborn as initial presentation of uterus didelphys
Saleh F, Gaeta M, Rost I, Vash-Margita A. Vaginal bleeding in a newborn as initial presentation of uterus didelphys. BMJ Case Reports 2023, 16: e251017. PMID: 36750302, PMCID: PMC9906268, DOI: 10.1136/bcr-2022-251017.Peer-Reviewed Original ResearchConceptsVaginal bleedingUterus didelphysTransabdominal ultrasoundHeavy vaginal bleedingAbnormal vaginal bleedingMüllerian anomaliesInitial presentationEndometrial tissueEstrogen levelsHeavy bleedingSurgical interventionUtero exposureAssociated conditionPostnatal periodBleedingBaby girlDidelphysNewbornsRoutine considerationNormal phenomenonUltrasoundNeonatesDiagnosisVulvar Aphthous Ulcers in Perimenarchal Adolescents after COVID-19 Vaccination: A Multicenter Case Series
Sartor R, Lawson A, Moncada-Madrazo M, Altchek C, Vash-Margita A, Cron J. Vulvar Aphthous Ulcers in Perimenarchal Adolescents after COVID-19 Vaccination: A Multicenter Case Series. Journal Of Pediatric And Adolescent Gynecology 2023, 36: 268-272. PMID: 36708984, PMCID: PMC9876002, DOI: 10.1016/j.jpag.2023.01.003.Peer-Reviewed Original ResearchConceptsCOVID-19 vaccinationAphthous ulcersCase seriesMulticenter case seriesAdolescent gynecology serviceVulvar ulcersDiagnostic workupGynecology serviceTreatment modalitiesPatient presentationDifferential diagnosisClinical experienceUlcersVaccinationTemporal associationFemale adolescentsCOVID-19Novel associationsAdolescentsAssociationOverall coursePresentationComplicationsPatientsVaccineOvarian absence: a systematic literature review and case series report
Chen H, Grimshaw A, Taylor-Giorlando M, Vijayakumar P, Li D, Margetts M, Pelosi E, Vash-Margita A. Ovarian absence: a systematic literature review and case series report. Journal Of Ovarian Research 2023, 16: 13. PMID: 36642704, PMCID: PMC9841619, DOI: 10.1186/s13048-022-01090-1.Peer-Reviewed Original ResearchConceptsOvarian absenceUterine abnormalitiesVascular accidentRenal abnormalitiesInfertility/subfertilityCase series reportWeb of SciencePelvic painDiagnostic laparoscopyClinical presentationVascular etiologyOvid EmbaseCochrane LibraryFrequent presentationUncommon conditionSeries reportCongenital anomaliesOvid MEDLINEOvarian abnormalitiesFertility considerationsGenitourinary anatomyExclusion criteriaEmbryological defectUnpublished casesSystematic review
2022
Optimizing menstrual health and hygiene management in the U.S.: A mixed-methods study of the barriers and the role of healthcare professionals
Trant A, Espinal M, Kisanga E, Vash-Margita A, Lundsberg L, Sheth S, Fan L. Optimizing menstrual health and hygiene management in the U.S.: A mixed-methods study of the barriers and the role of healthcare professionals. Sexual & Reproductive Healthcare 2022, 35: 100808. PMID: 36563412, DOI: 10.1016/j.srhc.2022.100808.Peer-Reviewed Original ResearchConceptsResponse rateSurvey response rateThematic content analysisMH screeningPatient interviewsPatient surveyPatient understandingPatient's abilityPatientsHealthcare providersHealthcare professionalsHealth practicesMedical staffMenstrual productsStaff viewsDaily activitiesMixed-method studyMenstrual healthMenstruationDescriptive statisticsHealthHygiene managementScreeningAnnual incomeQualitative interviewsEvaluation of the Association of Endometrial Thickness, Insulin Resistance, and Menstrual Patterns in Adolescent Females with Polycystic Ovarian Syndrome
Lynn A, Solomon N, Zamani M, Rowe E, Seifer D, Vash-Margita A. Evaluation of the Association of Endometrial Thickness, Insulin Resistance, and Menstrual Patterns in Adolescent Females with Polycystic Ovarian Syndrome. Journal Of Pediatric And Adolescent Gynecology 2022, 36: 134-139. PMID: 36403727, DOI: 10.1016/j.jpag.2022.11.005.Peer-Reviewed Original ResearchConceptsPCOS groupInsulin resistanceMenstrual patternAdolescent femalesControl groupRetrospective case-control studyLarge-scale prospective studiesAcute pelvic painEndometrial stripe thicknessTransabdominal pelvic ultrasoundTertiary children's hospitalPolycystic ovarian syndromeBody mass indexCase-control studyInstitutional review boardAdolescent PCOSEndometrial thicknessPelvic painOvarian syndromePCOS diagnosisPelvic ultrasoundUnique pathophysiologyEndocrinology clinicChildren's HospitalMass indexFunctional genomics analysis identifies loss of HNF1B function as a cause of Mayer–Rokitansky–Küster–Hauser syndrome
Thomson E, Tran M, Robevska G, Ayers K, van der Bergen J, Bhaskaran PG, Haan E, Cereghini S, Vash-Margita A, Margetts M, Hensley A, Nguyen Q, Sinclair A, Koopman P, Pelosi E. Functional genomics analysis identifies loss of HNF1B function as a cause of Mayer–Rokitansky–Küster–Hauser syndrome. Human Molecular Genetics 2022, 32: 1032-1047. PMID: 36282544, PMCID: PMC9990990, DOI: 10.1093/hmg/ddac262.Peer-Reviewed Original ResearchConceptsSingle-cell RNA sequencingKüster-Hauser syndromeMRKH syndromeType II phenotypeRNA sequencingGenetic basisCandidate genesPathways downstreamMicroarray analysisMolecular mechanismsMayer-RokitanskyFirst mouse modelReproductive healthChromosomal changesCell proliferationHypoplastic developmentLhx1HNF1BWomen's reproductive healthGenetic settingExtragenital anomaliesIdentifies lossClinical genetics settingPhenotypeType IILaparoscopic ovarian tissue harvesting for cryopreservation from a child with galactosemia
Vash-Margita A, Szymanska-Vandendriessche K, Gunther K, Rodriguez-Buritica DF, Christison-Lagay E, Saluja S, Oktay KH. Laparoscopic ovarian tissue harvesting for cryopreservation from a child with galactosemia. Fertility And Sterility 2022, 118: 982-984. PMID: 36154768, DOI: 10.1016/j.fertnstert.2022.08.005.Peer-Reviewed Original ResearchConceptsAntimüllerian hormone levelsOvarian tissue cryopreservationFertility preservationMonths of ageHormone levelsPrimordial folliclesAMH levelsMIU/Right ovaryTissue cryopreservationOvarian tissueReproductive endocrinologyOvarian tissue harvestingLower AMH levelsUneventful postoperative courseGood metabolic controlPelvic magnetic resonanceSubsequent histological examinationSmall antral folliclesPrimary ovarian insufficiencyTissue harvestingEffect of cauterizationYoung female childMagnetic resonance imaging (MRI) examsRare genetic disorderEstablishing an Association between Polycystic Ovarian Syndrome and Pilonidal Disease in Adolescent Females
Adjei NN, Yung N, Towers G, Caty M, Solomon D, Vash-Margita A. Establishing an Association between Polycystic Ovarian Syndrome and Pilonidal Disease in Adolescent Females. Journal Of Pediatric And Adolescent Gynecology 2022, 36: 39-44. PMID: 35995086, DOI: 10.1016/j.jpag.2022.08.005.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromePilonidal diseaseBody mass indexAdolescent femalesRotterdam criteriaOvarian syndromeMass indexHospital participantsFeatures of PCOSTreatment of PCOSRetrospective cohort study SETTINGUrban tertiary medical centerHigher body mass indexCohort study SETTINGTertiary medical centerAdolescent medicine specialistsRace/ethnicityDisease courseMetabolic syndromePayer statusSerum markersPrevalence ratiosMedical CenterTobacco useMedicine specialistsMinimally Invasive Ovarian-Preserving Approach for the Management of a Sclerosing Stromal Tumor in an Adolescent: A Case Report
Ahuja C, Tymon-Rosario J, Rottmann D, Raad RA, Silasi DA, Vash-Margita A. Minimally Invasive Ovarian-Preserving Approach for the Management of a Sclerosing Stromal Tumor in an Adolescent: A Case Report. Journal Of Pediatric And Adolescent Gynecology 2022, 35: 505-508. PMID: 35123057, DOI: 10.1016/j.jpag.2022.01.008.Peer-Reviewed Original ResearchConceptsOvarian massesStromal tumorsRare benign ovarian tumorConstant abdominal painLeft ovarian massEvidence of malignancyBenign ovarian tumorsSclerosing Stromal TumorAbdominal painAbdominal massAbnormal findingsIntraoperative findingsSurgical findingsCystic massLeft adnexaOvarian tumorsCase reportLeft ovaryPhysical examPostpubertal femalesInvasive approachPelvis CTBenign natureAdolescent populationYoung adultsSystematic Literature Review of Pediatric Male and Female Genital Hair Thread Tourniquet Syndrome
Adjei NN, Lynn AY, Grimshaw A, Brault MA, Dugan K, Vash-Margita A. Systematic Literature Review of Pediatric Male and Female Genital Hair Thread Tourniquet Syndrome. Pediatric Emergency Care 2022, 38: e799-e804. PMID: 35100779, DOI: 10.1097/pec.0000000000002383.Peer-Reviewed Original ResearchConceptsHair-thread tourniquet syndromeTourniquet syndromeAdolescent health care providersSystematic literature reviewHealth care providersEmergency medicine physiciansLiterature reviewUrinary symptomsSerious sequelaeAnesthetic typePrompt diagnosisFemale patientsGeneral anesthesiaAdolescent patientsFemale casesMale casesMAIN OUTCOMECare providersMedicine physiciansNational guidelinesAverage agePrevention strategiesPediatric malesLabia minoraPatient careMenstrual Health and Hygiene among Adolescents in the United States
Trant AA, Vash-Margita A, Camenga D, Braverman P, Wagner D, Espinal M, Kisanga EP, Lundsberg L, Sheth SS, Fan L. Menstrual Health and Hygiene among Adolescents in the United States. Journal Of Pediatric And Adolescent Gynecology 2022, 35: 277-287. PMID: 34999229, DOI: 10.1016/j.jpag.2021.12.014.Peer-Reviewed Original ResearchConceptsMenstrual health educationHealth educationSurvey response rateHealth careResponse rateMenstrual healthTertiary academic centerAdolescent medicine clinicMedicine clinicPatient interviewsPatient surveyGynecology practiceProvider surveyAcademic centersPatientsThematic saturationProvider perspectivesThematic content analysisProvider rolesAnonymous surveyCarePediatric facultyDescriptive statisticsMenstrual productsHealthThe SWIFT Model for Lichen Sclerosus Among Premenarchal Girls
Wang M, Wininger M, Vash-Margita A. The SWIFT Model for Lichen Sclerosus Among Premenarchal Girls. Journal Of Lower Genital Tract Disease 2022, 26: 46-52. PMID: 34928252, DOI: 10.1097/lgt.0000000000000634.Peer-Reviewed Original ResearchConceptsPremenarchal girlsLichen sclerosusLog oddsPilot studyAccurate risk stratificationRetrospective chart reviewAdolescent gynecology clinicUseful prognostic toolMajor academic centersPremenarchal patientsChart reviewUrinary incontinenceGynecology clinicRisk stratificationUnique patientsPatient populationSingle institutionVulvovaginal complaintsTimely diagnosisPrognostic toolAcademic centersClitoral hoodClinical diagnosisPatientsDiagnosis
2021
The Embryological Landscape of Mayer-Rokitansky-Kuster-Hauser Syndrome: Genetics and Environmental Factors.
Kyei-Barffour I, Margetts M, Vash-Margita A, Pelosi E. The Embryological Landscape of Mayer-Rokitansky-Kuster-Hauser Syndrome: Genetics and Environmental Factors. The Yale Journal Of Biology And Medicine 2021, 94: 657-672. PMID: 34970104, PMCID: PMC8686787.Peer-Reviewed Original ResearchConceptsMRKH syndromeClinical presentationMayer-RokitanskyEmbryonic developmentEnvironmental factorsEpigenetic changesFunctional validationCandidate genesGenetic analysisMolecular mechanismsDevelopmental pathwaysKüster-Hauser syndromeEarly organogenesisKuster-Hauser syndromeKey pathwaysGenetic componentInheritance patternEnvironmental compoundsIncomplete penetranceClinical managementDiscordant phenotypesEarly diagnosisAnimal modelsGeneticsTranslational studies