2025
24 Differences of sex development: Overview and clinical guide
Trotman G, Vash-Margita A. 24 Differences of sex development: Overview and clinical guide. 2025, 257-275. DOI: 10.1016/b978-0-443-10512-8.00033-3.Peer-Reviewed Original ResearchDifferences of sex developmentSex developmentGroup of congenital conditionsApproach to treatmentPatient-centered modelCongenital conditionExternal genitaliaDSD diagnosisPatient well-beingAtypical developmentClinical guideReproductive tractPatientsPsychosocial needsMultidisciplinary approachWell-beingClinical concepts10 Dysmenorrhea and endometriosis in the adolescent female
Davis-Kankanamge C, Vash-Margita A. 10 Dysmenorrhea and endometriosis in the adolescent female. 2025, 86-98. DOI: 10.1016/b978-0-443-10512-8.00019-9.Peer-Reviewed Original ResearchPelvic painCause of secondary dysmenorrheaTreatment of pelvic painGonadotropin-releasing hormone agonistQuality of lifeCombination of estrogenDevelopment of treatment modalitiesDiagnosis of endometriosisDevelopment of noninvasive biomarkersTreatment of endometriosisNonsteroidal antiinflammatory drugsImpaired quality of lifeRetrograde blood flowMedical treatment regimensNeuropathic medicationsOvarian pathologySecondary dysmenorrheaHistological diagnosisHormone agonistSurgical treatmentImprove quality of lifeTreatment modalitiesTreatment regimensAdolescent patientsAntiinflammatory drugs
2024
The Association of Polycystic Ovarian Syndrome and Adnexal Pathologies in Adolescents
Lynn A, Lepore C, Solomon N, Zamani M, Sailer A, Kuehne A, Rowe E, Vash-Margita A. The Association of Polycystic Ovarian Syndrome and Adnexal Pathologies in Adolescents. Journal Of Obstetrics And Gynaecology Canada 2024, 46: 102634. PMID: 39142633, DOI: 10.1016/j.jogc.2024.102634.Peer-Reviewed Original ResearchImpact of luteoma during pregnancy on fetal development and its long-term effects into adulthood
Mavrantoni I, Borneman R, Hittelman A, Vash-Margita A. Impact of luteoma during pregnancy on fetal development and its long-term effects into adulthood. BMJ Case Reports 2024, 17: e259373. PMID: 39117365, DOI: 10.1136/bcr-2023-259373.Peer-Reviewed Original ResearchConceptsVaginal stenosisClinical follow-upTime of birthDilator usePosterior vaginoplastyAcademic medical centreTertiary care academic medical centreFetal developmentElevated androgensFollow-upMedical historyPenetrative intercourseMedical CentreLong-term effectsLuteomaLaboratory investigationsVaginoplastyPregnancyVaginaStenosisPatientsPsychosocial implicationsVirilisationCystoscopyIntroitusReduction in Unindicated Cervical Cancer Screening in Adolescents in a Large Health Care System.
Geng B, Oliveira C, Hosier H, Sheth S, Vash-Margita A. Reduction in Unindicated Cervical Cancer Screening in Adolescents in a Large Health Care System. Journal Of Lower Genital Tract Disease 2024 PMID: 39037856, DOI: 10.1097/lgt.0000000000000831.Peer-Reviewed Original ResearchBest Practice AdvisoryCervical cancer screeningElectronic medical recordsHealth care systemCancer screeningPap testCare systemLarger health care systemPre/post intervention studyEvidence-based guidelinesProvider notificationPostinterventionPractice advisoryIntervention studiesPreinterventionFisher's exact testHuman papillomavirus test resultsLogistic regressionRetrospective chart reviewReproductive healthMedical recordsHuman papillomavirus testingPatient characteristicsChart reviewKruskal-Wallis testMedical Management of Endometriosis in Adolescent and Young Adult Women: A Review of 91 Cases of Biopsy-Confirmed Endometriosis
Li H, Esencan E, Song Y, Taylor H, Cho Y, Vash-Margita A. Medical Management of Endometriosis in Adolescent and Young Adult Women: A Review of 91 Cases of Biopsy-Confirmed Endometriosis. Journal Of Obstetrics And Gynaecology Canada 2024, 46: 102562. PMID: 38759792, DOI: 10.1016/j.jogc.2024.102562.Peer-Reviewed Original ResearchCombined oral contraceptivesBiopsy-proven endometriosisLNG-IUDManagement of endometriosisOral progestinInitial treatmentRetrospective chart review of womenChart review of womenMedical management of endometriosisProgestin-only formulationsLevonorgestrel intrauterine deviceReview of womenRetrospective chart reviewYoung adult patientsTertiary hospital systemPelvic painIntrauterine deviceOral contraceptivesTreatment regimensYounger patientsAdult patientsHormonal managementEndometriosisTreatment planningCurrent treatmentA common curriculum in obstetrics and gynecology for medical students globally
Atiomo W, Casper G, Symonds I, Obermair H, Gwako G, Vash‐Margita A, Sosa C, Kihara A, Ezimokhai M, Fogarty P. A common curriculum in obstetrics and gynecology for medical students globally. International Journal Of Gynecology & Obstetrics 2024, 167: 191-196. PMID: 38666747, DOI: 10.1002/ijgo.15544.Peer-Reviewed Original ResearchWomen's health outcomesMedical studentsHealth outcomesInternational taskforceGynecology curriculumClinical skillsHealth conditionsGynecologyGlobal health issueObstetricsHealth issuesMedical schoolsProfessional behaviorPublished curriculaGynecologistsObstetriciansWomenIncreased international migrationOutcomesTaskforceRecommended curriculumCurriculumHealthCultural context83. Mapping the Consumer Health Information Landscape for Mullerian Anomalies in NNLM Region 4
Grimshaw A, MacCarter B, Holt N, Vash-Margita A, Margetts M. 83. Mapping the Consumer Health Information Landscape for Mullerian Anomalies in NNLM Region 4. Journal Of Pediatric And Adolescent Gynecology 2024, 37: 277. DOI: 10.1016/j.jpag.2024.01.090.Peer-Reviewed Original ResearchConsumer health informationHealth informationInterdisciplinary team of healthcare professionalsTeam of healthcare professionalsRural healthcare accessAppropriate health informationHealth care systemHealth information landscapeHealth information gapsMullerian anomaliesConsumer health resourcesHealthcare accessHealthcare professionalsComprehensive careHealth resourcesCare systemSocial media groupsAssociation websitesInterdisciplinary teamAssessment toolMedline PlusFemale populationRural areasRural partsFlesch-Kincaid104. Polycystic Ovary Syndrome and Mental Health Co-Morbidities in Adolescents
ONeill N, Lynn A, Zamani M, Kuehne A, Miclette K, Rowe E, Fussner L, Vash-Margita A. 104. Polycystic Ovary Syndrome and Mental Health Co-Morbidities in Adolescents. Journal Of Pediatric And Adolescent Gynecology 2024, 37: 288-289. DOI: 10.1016/j.jpag.2024.01.111.Peer-Reviewed Original ResearchPolycystic ovary syndromeVitD supplementationMental health disordersHormone treatmentCohort studyRetrospective cohort studyYears post-menarcheModified Rotterdam criteriaFisher's exact testTertiary children's hospitalWilcoxon rank sum testEffects of hormonal treatmentAssociated with polycystic ovary syndromeCharacteristics of polycystic ovary syndromeRank sum testGender-affirming treatmentVitD levelsPrevalence of mental health disordersOvarian volumeMental health co-morbiditiesTreatment modalitiesEndocrinology clinicExact testPost-menarcheAnxiety diagnosesAltered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity
Slusher A, Nouws J, Tokoglu F, Vash‐Margita A, Matthews M, Fitch M, Shankaran M, Hellerstein M, Caprio S. Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity. Obesity 2024, 32: 593-602. PMID: 38410080, PMCID: PMC11034857, DOI: 10.1002/oby.23974.Peer-Reviewed Original ResearchConceptsSubcutaneous adipose tissueLiver fat contentInsulin resistanceInsulin sensitivityEctopic storage of lipidOral glucose tolerance testGluteal subcutaneous adipose tissueExtracellular matrix dynamicsMagnetic resonance imaging scansAdipose tissueBody fat distribution patternsFibrogenesis in vivoAdipocyte turnoverAssociated with insulin resistanceGlucose tolerance testFat distribution patternsWhole-body IRAdipose tissue insulin signalingTissue insulin signalingTolerance testGluteal fatImaging scansPathophysiological pathwaysAssociated with ratioObesity
2023
Ovarian Leydig Cell Tumor Associated with Recurrent Torsion and Virilization in an Adolescent Patient
Roth L, Smith A, Buza N, Coons B, Stitelman D, Vash-Margita A. Ovarian Leydig Cell Tumor Associated with Recurrent Torsion and Virilization in an Adolescent Patient. Journal Of Pediatric And Adolescent Gynecology 2023, 37: 217-219. PMID: 38110028, DOI: 10.1016/j.jpag.2023.11.014.Peer-Reviewed Original ResearchPolycystic ovarian syndromeOvarian tumorsCell tumorsRecurrent ovarian torsionAbnormal uterine bleedingPost-menopausal womenLeydig cell tumorUterine bleedingOvarian syndromeOvarian torsionYounger patientsOvarian functionOvarian hilumAdolescent patientsNodular proliferationSecrete androgensTumor AssociatedRecurrent torsionPrimary amenorrheaCurrent recommendationsReinke crystalsTumorsLeydig cellsIncidence increasesVirilizationAssessment of a Novel Interactive Website to Inform Adolescent and Young Adult Decision-Making about Contraception
Lepore C, McNamara M, Miclette K, Vash-Margita A. Assessment of a Novel Interactive Website to Inform Adolescent and Young Adult Decision-Making about Contraception. Journal Of Pediatric And Adolescent Gynecology 2023, 37: 149-155. PMID: 37935279, DOI: 10.1016/j.jpag.2023.10.006.Peer-Reviewed Original ResearchOral contraceptive pillsYoung adultsNon-contraceptive usesTertiary children's hospitalReproductive health informationTeen healthWebsite exposureChildren's HospitalMean ageOutpatient clinicContraceptive pillsContraception methodsHealth educationExposure surveyParticipant demographicsAYAsConvenience sampleHealth informationAdolescent HealthElectronic surveyFurther studiesClinical institutionsHospitalContraceptionExposureAlterations in Adipose Tissue Distribution, Cell Morphology, and Function Mark Primary Insulin Hypersecretion in Youth With Obesity
Tricò D, Chiriacò M, Nouws J, Vash-Margita A, Kursawe R, Tarabra E, Galderisi A, Natali A, Giannini C, Hellerstein M, Ferrannini E, Caprio S. Alterations in Adipose Tissue Distribution, Cell Morphology, and Function Mark Primary Insulin Hypersecretion in Youth With Obesity. Diabetes 2023, 73: 941-952. PMID: 37870826, PMCID: PMC11109779, DOI: 10.2337/db23-0450.Peer-Reviewed Original ResearchPrimary insulin hypersecretionΒ-cell glucose sensitivityAdipose tissue distributionInsulin hypersecretionInsulin resistanceGlucose toleranceUnfavorable metabolic phenotypeWorse glucose toleranceLeptin serum levelsAbnormal glucose toleranceTissue distributionExcessive insulin secretionHigher leptin levelsVisceral fat depotsNon-diabetic adolescentsEuglycemic hyperinsulinemic clampWhole-body adiposityAbdominal subcutaneous adipocytesBody weight gainGlucose sensitivityPrimary hypersecretionGlucose intoleranceSerum levelsLeptin levelsChronic hyperinsulinemiaUnindicated Cervical Cancer Screening in Adolescent Females Within a Large Healthcare System in the United States
Hosier H, Sheth S, Oliveira C, Perley L, Vash-Margita A. Unindicated Cervical Cancer Screening in Adolescent Females Within a Large Healthcare System in the United States. Obstetrical & Gynecological Survey 2023, 78: 470-472. DOI: 10.1097/ogx.0000000000001179.Commentaries, Editorials and LettersCervical cancer screeningIncidence rateUnindicated testsPatient-specific variablesCervical cancerCancer screeningHPV testingYale New Haven Health SystemCervical cancer screening testsAdolescent femalesEligible young womenRepeated cross-sectional studyWell-woman examinationsAtypical squamous cellsHealth system patientsCancer screening testsWomen ages 21Cross-sectional studyLow incidence rateLarge healthcare systemElectronic medical recordsEvidence-based strategiesSelf-reported raceGuideline adherenceHPV testThe impact of the war in Ukraine on the reproductive health of female military personnel
Serbeniuk A, Kaminskiy V, Kumpanenko Y, Vash‐Margita A, Malysheva I. The impact of the war in Ukraine on the reproductive health of female military personnel. International Journal Of Gynecology & Obstetrics 2023, 163: 409-415. PMID: 37458251, DOI: 10.1002/ijgo.14990.Peer-Reviewed Original ResearchConceptsFemale military personnelLong menstrual periodsTimes higher likelihoodActive duty personnelMilitary personnelInfertility durationPainful menstruationPhysical examinationMedical historyMenstrual periodReproductive system pathologyHeavy periodsStructural pathologyPerinatal medicineSystem pathologyReproductive healthFemale veteransMental healthHealth declineLonger durationWomenHigher likelihoodConcussionPathologyTimes longer durationSurgical Correction of Vaginal Agenesis via Modified Laparoscopic Vecchietti Procedure
Esencan E, St Martin B, Harmanli O, Vash-Margita A. Surgical Correction of Vaginal Agenesis via Modified Laparoscopic Vecchietti Procedure. Journal Of Pediatric And Adolescent Gynecology 2023, 36: 556-559. PMID: 37354985, DOI: 10.1016/j.jpag.2023.06.004.Peer-Reviewed Original ResearchConceptsLaparoscopic Vecchietti procedureVecchietti procedureVaginal dilationVaginal agenesisSurgical correctionRudimentary uterine hornExtensive counselingMayer-RokitanskyNormal ovariesSuture adjustmentPrimary amenorrheaSecondary sex characteristicsUterine hornVaginal canalAgenesisSex characteristicsType IDilationUnsuccessful attemptsAmenorrheaNeovaginaPatientsVaginoplastyMucosaGraftPremenarchal lichen sclerosus: a multicentre examination of the novel diagnostic tool, the SWIFT model
Lawson A, Wininger M, Wang M, Steger M, Peccerillo K, Vash-Margita A. Premenarchal lichen sclerosus: a multicentre examination of the novel diagnostic tool, the SWIFT model. British Journal Of Dermatology 2023, 189: 353-354. PMID: 37235769, DOI: 10.1093/bjd/ljad180.Peer-Reviewed Original ResearchDiagnostic and surgical approaches to congenital uterine anomalies for the minimally invasive gynecologic surgeon
Murphy C, Wilcox A, Vash-Margita A. Diagnostic and surgical approaches to congenital uterine anomalies for the minimally invasive gynecologic surgeon. Current Opinion In Obstetrics & Gynecology 2023, 35: 328-336. PMID: 37266575, DOI: 10.1097/gco.0000000000000886.Peer-Reviewed Original ResearchConceptsCongenital uterine anomaliesUterine anomaliesGynecologic surgeonsInvasive gynecologic surgeonsInvasive surgical techniquesStandardized classification systemPerioperative considerationsSurgical approachSurgical techniqueClinical scenariosProvider useReproductive medicinePsychosocial wellbeingAmerican SocietySurgeonsTreatmentClassification systemPatientsReviewWorkupVulvovaginal Complaints as the First Manifestation of Crohn's Disease in Children: Case Report
Brioso X, Banks D, Christison-Lagay E, Phatak U, Vash-Margita A. Vulvovaginal Complaints as the First Manifestation of Crohn's Disease in Children: Case Report. Journal Of Pediatric And Adolescent Gynecology 2023, 36: 494-496. PMID: 37196754, DOI: 10.1016/j.jpag.2023.05.007.Peer-Reviewed Original ResearchConceptsCrohn's diseasePediatric gynecologistImprovement of symptomsGastrointestinal inflammatory conditionsChronic constipationPrompt diagnosisPediatric populationVulvar irritationPremenarchal femalesVulvar complaintsCase reportInflammatory conditionsFirst manifestationVulvovaginal complaintsClear diagnosisHigh indexDiseaseDiagnosisFirst signAnatomical changesGynecologistsComplaintsTreatmentChildrenPoor growth86. Leydig Cell Tumor in an Adolescent
Roth L, Smith A, Buza N, Coons B, Stitleman D, Vash-Margita A. 86. Leydig Cell Tumor in an Adolescent. Journal Of Pediatric And Adolescent Gynecology 2023, 36: 210. DOI: 10.1016/j.jpag.2023.01.229.Peer-Reviewed Original ResearchLeydig cell tumorOvarian stromal tumorsCell tumorsOvarian tumorsRight ovaryPrimary amenorrheaOvarian torsionStromal tumorsLeydig cell ovarian tumorsOvarian Leydig cell tumorAreas of hypodensityEnlarged right ovaryQuadrant abdominal painMainstay of treatmentIntraoperative frozen sectionTanner stage 4Breast stage 3Years of ageAbsent menarcheLaparoscopic detorsionAbdominal painFinal pathologyPostmenopausal womenRight oophorectomyPostoperative course