Global gene expression of histologically normal primary skin cells from BCNS subjects reveals “single-hit” effects that are influenced by rapamycin
Phatak A, Athar M, Crowell JA, Leffel D, Herbert BS, Bale AE, Kopelovich L. Global gene expression of histologically normal primary skin cells from BCNS subjects reveals “single-hit” effects that are influenced by rapamycin. Oncotarget 2019, 10: 1360-1387. PMID: 30858923, PMCID: PMC6402716, DOI: 10.18632/oncotarget.26640.Peer-Reviewed Original ResearchGlobal gene expressionRapamycin treatmentGene expression changesGene expression profilingPresence of rapamycinBiomarkers/targetsExpression profilingGene expressionExpression changesPrimary cell culturesWnt pathwayCanonical HhGenesProbe setsMitochondrial dysfunctionStellate cell activationUnaffected skin biopsiesHeritable cancersPrimary skin cellsStem cellsRapamycinDevelopmental abnormalitiesDifferential responseGene signatureNormal fibroblasts