2024
NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7
Gordon R, Cosgrove H, Marinov A, Gingras S, Tilstra J, Campbell A, Bastacky S, Kashgarian M, Perl A, Nickerson K, Shlomchik M. NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7. JCI Insight 2024, 9: e178563. PMID: 39042716, PMCID: PMC11343599, DOI: 10.1172/jci.insight.178563.Peer-Reviewed Original ResearchSystemic lupus erythematosusB cellsRegulation of TLR7Cell lineagesNADPH oxidaseHematopoietic cell lineagesNF-kB signalingSLE pathologyNOX2 deficiencyMyeloid compartmentMurine lupusLupus nephritisLupus erythematosusTLR7 signalingGlobal deletionInterstitial nephritisImmunomodulatory effectsGlobal knockoutConditional knockoutCYBBNOX2NephritisKnockoutTLR7Chimera approach
2018
Harnessing the Immunomodulatory Effects of Radiation Therapy.
Campbell AM, Decker RH. Harnessing the Immunomodulatory Effects of Radiation Therapy. Oncology 2018, 32: 370-4, cv3. PMID: 30080922.Peer-Reviewed Original ResearchConceptsImmunomodulatory effectsImmune responseImmune systemSetting of cancerSystemic immune responsesAntitumoral immune responseInnate immune systemAdaptive immune systemCell deathTumor cell deathAntitumoral immunityAntitumoral responseHypofractionated radiationRadiotherapy timingProinflammatory responsePreclinical modelsAdaptive immunityRadiation therapyClinical informationRadiation-induced cell deathDoseImmunityDeathPotential superiorityDNA damage