2024
NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7
Gordon R, Cosgrove H, Marinov A, Gingras S, Tilstra J, Campbell A, Bastacky S, Kashgarian M, Perl A, Nickerson K, Shlomchik M. NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7. JCI Insight 2024, 9: e178563. PMID: 39042716, PMCID: PMC11343599, DOI: 10.1172/jci.insight.178563.Peer-Reviewed Original ResearchSystemic lupus erythematosusB cellsRegulation of TLR7Cell lineagesNADPH oxidaseHematopoietic cell lineagesNF-kB signalingSLE pathologyNOX2 deficiencyMyeloid compartmentMurine lupusLupus nephritisLupus erythematosusTLR7 signalingGlobal deletionInterstitial nephritisImmunomodulatory effectsGlobal knockoutConditional knockoutCYBBNOX2NephritisKnockoutTLR7Chimera approach
2017
Lupus and proliferative nephritis are PAD4 independent in murine models
Gordon RA, Herter JM, Rosetti F, Campbell AM, Nishi H, Kashgarian M, Bastacky SI, Marinov A, Nickerson KM, Mayadas TN, Shlomchik MJ. Lupus and proliferative nephritis are PAD4 independent in murine models. JCI Insight 2017, 2: e92926. PMID: 28515361, PMCID: PMC5436537, DOI: 10.1172/jci.insight.92926.Peer-Reviewed Original ResearchSystemic lupus erythematosusNeutrophil extracellular trapsProliferative nephritisMurine modelContribution of NETsInhibition of NETsAnti-glomerular basement membrane modelEnd-organ damageLoss of toleranceRecent reportsLupus erythematosusOrgan injuryImmune activationExtracellular trapsPeptidyl arginine deiminasePharmacological approachesBasement membrane modelDistal mediatorsNADPH oxidase complexPharmacological inhibitionNephritisInducible modelLupusNET formationType IV
2015
Suppression of systemic autoimmunity by the innate immune adaptor STING
Sharma S, Campbell AM, Chan J, Schattgen SA, Orlowski GM, Nayar R, Huyler AH, Nündel K, Mohan C, Berg LJ, Shlomchik MJ, Marshak-Rothstein A, Fitzgerald KA. Suppression of systemic autoimmunity by the innate immune adaptor STING. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: e710-e717. PMID: 25646421, PMCID: PMC4343138, DOI: 10.1073/pnas.1420217112.Peer-Reviewed Original ResearchConceptsAutoimmune-prone miceSystemic lupus erythematosusImmune activationSerum cytokine levelsSTING-deficient miceCytosolic DNA-sensing pathwayToll-like receptorsDNA-sensing pathwayCytokine levelsSystemic inflammationLupus erythematosusAutoantibody productionLymphoid hypertrophyTLR ligandsProinflammatory cytokinesAutoimmune pathologySystemic autoimmunityInflammatory macrophagesAdaptor STINGElevated numbersMiceInflammationInterferon genesMacrophagesNegative regulatory role
2012
NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus
Campbell AM, Kashgarian M, Shlomchik MJ. NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus. Science Translational Medicine 2012, 4: 157ra141. PMID: 23100627, PMCID: PMC3704198, DOI: 10.1126/scitranslmed.3004801.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusNeutrophil extracellular trapsLupus erythematosusLupus-prone miceLupus-prone MRLSource of autoantigensLoss of toleranceSelf-nucleic acidsHeterozygous female miceAutoantibody patternsNOX2 deficiencySLE pathologyRenal diseaseAutoantibody profileLupus autoantigensImmune activationAutoimmune diseasesDisease onsetAutoantibody generationFemale miceExtracellular trapsDisease pathogenesisTherapeutic interventionsPhagocyte NADPH oxidaseLupus