A multi-step model for facilitated unwinding of the yeast U4/U6 RNA duplex
Rodgers M, Didychuk A, Butcher S, Brow D, Hoskins A. A multi-step model for facilitated unwinding of the yeast U4/U6 RNA duplex. Nucleic Acids Research 2016, 44: 10912-10928. PMID: 27484481, PMCID: PMC5159527, DOI: 10.1093/nar/gkw686.Peer-Reviewed Original ResearchConceptsSmall nuclear RNATri-snRNPU4/U6 unwindingU6 small nuclear RNAImpairs yeast growthSpliceosome active siteU4/U6 di-snRNPSmall nuclear ribonucleoproteinTri-snRNP assemblySpliceosome formationStrand invasionDi-snRNPYeast growthNuclear ribonucleoproteinNuclear RNARNA complexResonance energy transferSpliceosomeRNA duplexesForster resonance energy transferConformational rearrangementsDNA oligonucleotidesStem IIUnwindingU4/U6