2012
Interstitial Lung Disease in the Connective Tissue Diseases
Antin-Ozerkis D, Rubinowitz A, Evans J, Homer RJ, Matthay RA. Interstitial Lung Disease in the Connective Tissue Diseases. Clinics In Chest Medicine 2012, 33: 123-149. PMID: 22365251, DOI: 10.1016/j.ccm.2012.01.004.Peer-Reviewed Original ResearchConceptsConnective tissue diseaseInterstitial lung diseaseLung diseaseTissue diseaseIdiopathic interstitial lung diseaseFulminant respiratory failureCTD-ILDRespiratory failureImmunosuppressive agentsHealthy patientsDrug reactionsFirst manifestationGradual onsetDiseaseCareful searchSubtle evidenceDyspneaCorticosteroidsCoughPatientsInfectionDiagnosis
2011
Combined pulmonary fibrosis and emphysema syndrome: a radiologic perspective
Oliva IB, Cortopassi F, Rochester CL, Rubinowitz AN. Combined pulmonary fibrosis and emphysema syndrome: a radiologic perspective. Monaldi Archives For Chest Disease 2011, 75: 220-34. PMID: 22462310, DOI: 10.4081/monaldi.2011.210.Peer-Reviewed Original ResearchConceptsCombined pulmonary fibrosisIdiopathic pulmonary fibrosisPulmonary fibrosisLung zonesChronic Obstructive Pulmonary Disease - ResultsProgressive parenchymal lung diseaseParenchymal lung diseaseUpper lung zonesLower lung zonesFindings of emphysemaUnderdiagnosed syndromeRadiological findingsSignificant morbidityWorse prognosisEmphysema syndromeLung diseaseEarly recognitionRadiologic appearanceRadiologic perspectiveComputed tomographyClinical importanceDisease resultsFibrosisSyndromeRapid treatment
2010
Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype
Mathai SK, Gulati M, Peng X, Russell TR, Shaw AC, Rubinowitz AN, Murray LA, Siner JM, Antin-Ozerkis DE, Montgomery RR, Reilkoff RA, Bucala RJ, Herzog EL. Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype. Laboratory Investigation 2010, 90: 812-823. PMID: 20404807, PMCID: PMC3682419, DOI: 10.1038/labinvest.2010.73.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseSSc-ILD patientsSSc-ILDIL-10Normal controlsProfibrotic cellsSystemic sclerosisLung diseaseCollagen-producing cellsMCP-1Profibrotic phenotypeSSc-related interstitial lung diseaseFlow cytometryPeripheral blood profilesSSc-ILD cohortsIL-10 secretionSystemic sclerosis patientsExpression of CD163Blood of patientsHealthy aged controlsCultured CD14Profibrotic characteristicsProfibrotic mediatorsTNF levelsSclerosis patients