Plasma cell-free DNA variant analysis compared with methylated DNA analysis in renal cell carcinoma
Lasseter K, Nassar AH, Hamieh L, Berchuck JE, Nuzzo PV, Korthauer K, Shinagare AB, Ogorek B, McKay R, Thorner AR, Lee GM, Braun DA, Bhatt RS, Freedman M, Choueiri TK, Kwiatkowski DJ. Plasma cell-free DNA variant analysis compared with methylated DNA analysis in renal cell carcinoma. Genetics In Medicine 2020, 22: 1366-1373. PMID: 32341571, DOI: 10.1038/s41436-020-0801-x.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorCarcinoma, Renal CellCell-Free Nucleic AcidsDNAHigh-Throughput Nucleotide SequencingHumansKidney NeoplasmsPlasmaConceptsMRCC patientsCancer subtypesCfDNA analysisMetastatic RCC patientsRenal cell carcinomaMRCC casesRCC patientsCell carcinomaControl subjectsVariant analysisCfDNA variantsSeparate cohortPatientsSerial samplesGermline variantsTumor sequencingClonal hematopoiesisVariant findingsTherapyCandidate variantsSubtypesCancer detectionCfMeDIP-seqVariant frequencyCarcinoma