2020
Cause‐specific mortality after diagnosis of cancer among HIV‐positive patients: A collaborative analysis of cohort studies
Trickey A, May MT, Gill MJ, Grabar S, Vehreschild J, Wit F, Bonnet F, Cavassini M, Abgrall S, Berenguer J, Wyen C, Reiss P, Grabmeier‐Pfistershammer K, Guest JL, Shepherd L, Teira R, Monforte A, del Amo J, Justice A, Costagliola D, Sterne J. Cause‐specific mortality after diagnosis of cancer among HIV‐positive patients: A collaborative analysis of cohort studies. International Journal Of Cancer 2020, 146: 3134-3146. PMID: 32003460, PMCID: PMC7187452, DOI: 10.1002/ijc.32895.Peer-Reviewed Original ResearchConceptsCause-specific mortalityCause of deathMortality rateGeneral populationLymphoma diagnosisCancer diagnosisHodgkin lymphoma diagnosisHIV-positive patientsCause-specific mortality ratesDiagnosis of cancerHIV cohortCohort studyCervical cancerSurvival outcomesLung cancerPLHIVSpecific cancersCancerCancer typesDiagnosisMortalityDeathSurvivalNADMAIDS
2018
Increased non‐AIDS mortality among persons with AIDS‐defining events after antiretroviral therapy initiation
Pettit AC, Giganti MJ, Ingle SM, May MT, Shepherd BE, Gill MJ, Fätkenheuer G, Abgrall S, Saag MS, Del Amo J, Justice AC, Miro JM, Cavasinni M, Dabis F, Monforte AD, Reiss P, Guest J, Moore D, Shepherd L, Obel N, Crane HM, Smith C, Teira R, Zangerle R, Sterne JA, Sterling TR, investigators F. Increased non‐AIDS mortality among persons with AIDS‐defining events after antiretroviral therapy initiation. Journal Of The International AIDS Society 2018, 21: e25031. PMID: 29334197, PMCID: PMC5810321, DOI: 10.1002/jia2.25031.Peer-Reviewed Original ResearchConceptsAdjusted hazard ratioAntiretroviral therapy initiationAIDS mortalityAdjusted hazardCohort CollaborationTherapy initiationAntiretroviral Therapy Cohort CollaborationHIV-1 infectionTreatment-naïve adultsCause of deathMarginal structural modelsART initiationHIV protocolMetabolic deathHazard ratioChronic inflammationRisk factorsCoding CausesSubsequent deathMortalityAIDSCommon pathwayDeathUnmeasured confoundersCause
2016
Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000–2010
Buchacz K, Lau B, Jing Y, Bosch R, Abraham A, Gill M, Silverberg M, Goedert J, Sterling T, Althoff K, Martin J, Burkholder G, Gandhi N, Samji H, Patel P, Rachlis A, Thorne J, Napravnik S, Henry K, Mayor A, Gebo K, Gange S, Moore R, Brooks J, Research and Design of IeDEA F, Kirk G, Benson C, Bosch R, Boswell S, Mayer K, Grasso C, Hogg R, Harrigan P, Montaner J, Cescon A, Samji H, Brooks J, Buchacz K, Gebo K, Moore R, Moore R, Carey J, Rodriguez B, Horberg M, Silverberg M, Thorne J, Goedert J, Jacobson L, D'Souza G, Klein M, Rourke S, Burchell A, Rachlis A, Hunter-Mellado R, Mayor A, Gill M, Deeks S, Martin J, Patel P, Brooks J, Saag M, Mugavero M, Willig J, Eron J, Napravnik S, Kitahata M, Crane H, Drozd D, Sterling T, Rebeiro P, Haas D, Bebawy S, Turner M, Justice A, Dubrow R, Fiellin D, Gange S, Anastos K. Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000–2010. The Journal Of Infectious Diseases 2016, 214: 862-872. PMID: 27559122, PMCID: PMC4996145, DOI: 10.1093/infdis/jiw085.Peer-Reviewed Original ResearchConceptsFirst opportunistic infectionOpportunistic infectionsIncidence rateNorth American AIDS Cohort CollaborationIncident opportunistic infectionsPneumocystis jiroveci pneumoniaMycobacterium kansasii infectionRates of AIDSHuman immunodeficiency virusConfidence intervalsIncidence of AIDSMycobacterium avium complexCohort CollaborationAntiretroviral therapyJiroveci pneumoniaEsophageal candidiasisMulticohort analysisImmunodeficiency virusClinical eventsAvium complexHIVObservation periodInfectionAIDSRecent data
2015
Using observational data to emulate a randomized trial of dynamic treatment-switching strategies: an application to antiretroviral therapy
Cain LE, Saag MS, Petersen M, May MT, Ingle SM, Logan R, Robins JM, Abgrall S, Shepherd BE, Deeks SG, Gill M, Touloumi G, Vourli G, Dabis F, Vandenhende MA, Reiss P, van Sighem A, Samji H, Hogg RS, Rybniker J, Sabin CA, Jose S, del Amo J, Moreno S, Rodríguez B, Cozzi-Lepri A, Boswell SL, Stephan C, Pérez-Hoyos S, Jarrin I, Guest JL, Monforte A, Antinori A, Moore R, Campbell CN, Casabona J, Meyer L, Seng R, Phillips AN, Bucher HC, Egger M, Mugavero MJ, Haubrich R, Geng EH, Olson A, Eron JJ, Napravnik S, Kitahata MM, Van Rompaey SE, Teira R, Justice AC, Tate JP, Costagliola D, Sterne JA, Hernán MA, Systems A. Using observational data to emulate a randomized trial of dynamic treatment-switching strategies: an application to antiretroviral therapy. International Journal Of Epidemiology 2015, 45: 2038-2049. PMID: 26721599, PMCID: PMC5841611, DOI: 10.1093/ije/dyv295.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyCopies/Antiretroviral Therapy Cohort CollaborationTime-varying covariatesTight control groupAdjusted hazard ratioAntiretroviral therapy regimenAIDS Research NetworkIntegrated Clinical SystemsHIV-CAUSAL CollaborationDeath eventsCohort CollaborationHazard ratioTherapy regimenRandomized trialsInverse probability weightingInclusion criteriaMortality analysisClinical treatmentAIDSTherapyDeath analysisDeathTrialsComparative effects
2010
HIV and Aging: Time for a New Paradigm
Justice A. HIV and Aging: Time for a New Paradigm. Current HIV/AIDS Reports 2010, 7: 69-76. PMID: 20425560, DOI: 10.1007/s11904-010-0041-9.Peer-Reviewed Original ResearchConceptsHIV infectionNon-AIDS diseasesCombination antiretroviral therapyPopulation of patientsCause of morbidityComplex chronic diseaseSpectrum of diseaseProlong life expectancyAntiretroviral therapyCD4 countHIV RNAViral suppressionFunctional statusChronic diseasesPatient riskOptimal managementHIVInfectionLife expectancyDiseaseMorbidityMortalityAIDSRiskPatientsHIV/AIDS, comorbidity, and alcohol: can we make a difference?
Justice A, Sullivan L, Fiellin D, . HIV/AIDS, comorbidity, and alcohol: can we make a difference? Alcohol Research 2010, 33: 258-66. PMID: 23584067, PMCID: PMC3711181.BooksConceptsVeterans Aging Cohort StudyHIV infectionLong-term HIV infectionAlcohol useAging Cohort StudyHIV/AIDSAssociated comorbidityCohort studyHIV outcomesMedical managementIntervention trialsAlcohol consumptionHealth outcomesAlcohol treatmentMultisite studyComorbiditiesHIVInfectionOutcomesTreatmentAIDSDiseaseTrialsImportant role
2009
Prognosis of patients treated with cART from 36 months after initiation, according to current and previous CD4 cell count and plasma HIV-1 RNA measurements
Lanoy E, May M, Mocroft A, Phillip A, Justice A, Chêne G, Furrer H, Sterling T, Monforte A, Force L, Gill J, Harris R, Hogg R, Rockstroh J, Saag M, Khaykin P, de Wolf F, Sterne J, Costagliola D. Prognosis of patients treated with cART from 36 months after initiation, according to current and previous CD4 cell count and plasma HIV-1 RNA measurements. AIDS 2009, 23: 2199-2208. PMID: 19779320, PMCID: PMC3122149, DOI: 10.1097/qad.0b013e3283305a00.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyCD4 cell countHIV-1-infected patientsHIV-1 RNAViral loadCART initiationCell countStart of cARTHIV-1 RNA measurementsART Cohort CollaborationMedian CD4 cellPredictors of AIDSRates of AIDSImportant prognostic factorPrognosis of patientsCohort CollaborationSubsequent AIDSAntiretroviral therapyHIV cohortCD4 cellsPrognostic factorsPrognostic importanceCopies/PatientsAIDSTiming of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies
Sterne J, May M, Costagliola D, de Wolf F, Phillips A, Harris R, Funk M, Geskus R, Gill J, Dabis F, Miró J, Justice A, Ledergerber B, Fätkenheuer G, Hogg R, Monforte A, Saag M, Smith C, Staszewski S, Egger M, Cole S. Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. The Lancet 2009, 373: 1352-1363. PMID: 19361855, PMCID: PMC2670965, DOI: 10.1016/s0140-6736(09)60612-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountCohort StudiesDisease ProgressionDrug Administration ScheduleEuropeFemaleHIV InfectionsHIV-1HumansKaplan-Meier EstimateMaleMiddle AgedNorth AmericaPatient SelectionPractice Guidelines as TopicProportional Hazards ModelsSensitivity and SpecificityTime FactorsTreatment OutcomeConceptsHIV-1-infected patientsCombination antiretroviral therapyCD4 cell countAntiretroviral therapyCombination therapyCohort studyCell countCD4 cell count rangeCD4 cell count thresholdAntiretroviral-naive patientsProspective cohort studyHIV Cohort StudyRates of AIDSStart of treatmentHigh mortality rateAbsence of treatmentTiming of initiationDeath eventsCell count thresholdTherapy groupImmediate initiationPatientsMortality rateTherapyAIDS
2007
Prognosis of HIV-1-infected patients up to 5 years after initiation of HAART: collaborative analysis of prospective studies
May M, Sterne JA, Sabin C, Costagliola D, Justice AC, Thiébaut R, Gill J, Phillips A, Reiss P, Hogg R, Ledergerber B, D'Arminio Monforte A, Schmeisser N, Staszewski S, Egger M. Prognosis of HIV-1-infected patients up to 5 years after initiation of HAART: collaborative analysis of prospective studies. AIDS 2007, 21: 1185-1197. PMID: 17502729, PMCID: PMC3460385, DOI: 10.1097/qad.0b013e328133f285.Peer-Reviewed Original ResearchConceptsStart of HAARTCD4 cell countCell countHIV-1 RNA levelsHIV-1-infected patientsInitiation of HAARTTreatment-naive patientsDiagnosis of AIDSInjection drug useVirological responseHIV careNew AIDSCumulative incidenceParametric survival modelsClinical stageProspective studyRisk calculatorHAARTProgression rateTreatment changesPatientsDrug usePrognostic modelAIDSCells/
2006
Spirituality and Religion in Patients with HIV/AIDS
Cotton S, Puchalski CM, Sherman SN, Mrus JM, Peterman AH, Feinberg J, Pargament KI, Justice AC, Leonard AC, Tsevat J. Spirituality and Religion in Patients with HIV/AIDS. Journal Of General Internal Medicine 2006, 21: s5-s13. PMID: 17083501, PMCID: PMC1924778, DOI: 10.1111/j.1525-1497.2006.00642.x.Peer-Reviewed Original ResearchConceptsHIV/AIDSMean ageSpirituality/religionPatients' mean ageLower overall functioningDuke Religion IndexClinical characteristicsMost patientsHIV symptomsChronic illnessLess alcohol useMultivariable modelDepressive symptomsPatientsFunctional assessmentHealth statusClinical sitesLess alcoholAlcohol usePsychosocial variablesIllnessMean levelsAIDSReligion IndexGreater life satisfaction
2005
The Changing Incidence of AIDS Events in Patients Receiving Highly Active Antiretroviral Therapy
d'Arminio Monforte A, Sabin CA, Phillips A, Sterne J, May M, Justice A, Dabis F, Grabar S, Ledergerber B, Gill J, Reiss P, Egger M. The Changing Incidence of AIDS Events in Patients Receiving Highly Active Antiretroviral Therapy. JAMA Internal Medicine 2005, 165: 416-423. PMID: 15738371, DOI: 10.1001/archinte.165.4.416.Peer-Reviewed Original ResearchConceptsActive antiretroviral therapyAIDS eventsAntiretroviral therapyViral etiologyRate of declineAntiretroviral-naive individualsRates of AIDSIncidence of AIDSCohort CollaborationCD4 countMonths 0Different etiologiesFungal etiologyChanging IncidenceHAARTPoisson regressionEtiologyIncidenceRNA levelsAIDSViral eventsTherapyMonths
2004
The Veterans Aging Cohort Study: Observational Studies of Alcohol Use, Abuse, and Outcomes Among Human Immunodeficiency Virus–Infected Veterans
Conigliaro J, Madenwald T, Bryant K, Braithwaite S, Gordon A, Fultz SL, Maisto S, Samet J, Kraemer K, Cook R, Day N, Roach D, Richey S, Justice A. The Veterans Aging Cohort Study: Observational Studies of Alcohol Use, Abuse, and Outcomes Among Human Immunodeficiency Virus–Infected Veterans. Alcohol Clinical And Experimental Research 2004, 28: 313-321. PMID: 15112939, DOI: 10.1097/01.alc.0000113414.73220.21.Peer-Reviewed Original Research