2022
Epigenome-wide association study of biomarkers of liver function identifies albumin-associated DNA methylation sites among male veterans with HIV
Titanji BK, Lee M, Wang Z, Chen J, Hui Q, Re V, So-Armah K, Justice AC, Xu K, Freiberg M, Gwinn M, Marconi VC, Sun YV. Epigenome-wide association study of biomarkers of liver function identifies albumin-associated DNA methylation sites among male veterans with HIV. Frontiers In Genetics 2022, 13: 1020871. PMID: 36303554, PMCID: PMC9592923, DOI: 10.3389/fgene.2022.1020871.Peer-Reviewed Original ResearchLiver diseaseLiver biomarkersLiver functionDNAm age accelerationAge accelerationVeterans Aging Cohort StudyEpigenome-wide association studiesFIB-4 scoreAging Cohort StudyMale PWHAPRI scoreCohort studyPlatelet countTotal bilirubinAlanine transaminaseClinical dataBlood samplesIndependent cohortSerum albuminMale veteransHIVImportant causeSignificant associationPWHDNAm sitesSoluble CD14-associated DNA methylation sites predict mortality among men with HIV infection
Titanji BK, Wang Z, Chen J, Hui Q, So-Armah K, Freiberg M, Justice AC, Ke X, Marconi VC, Sun YV. Soluble CD14-associated DNA methylation sites predict mortality among men with HIV infection. AIDS 2022, 36: 1563-1571. PMID: 35979830, PMCID: PMC9394925, DOI: 10.1097/qad.0000000000003279.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyAging Cohort StudyElevated plasma levelsCox regression modelUnderstanding of prognosisPeripheral blood samplesPotential therapeutic targetEpigenome-wide association studiesMultiple testingCause mortalitySCD14 levelsCohort studyHIV infectionPlasma levelsSoluble CD14Disease progressionImmune functionSurvival timeBlood samplesSCD14Therapeutic targetPWHAntiviral responseSignificant associationDNAm sites
2018
Using DNA methylation to validate an electronic medical record phenotype for smoking
McGinnis KA, Justice AC, Tate JP, Kranzler HR, Tindle HA, Becker WC, Concato J, Gelernter J, Li B, Zhang X, Zhao H, Crothers K, Xu K, Group F. Using DNA methylation to validate an electronic medical record phenotype for smoking. Addiction Biology 2018, 24: 1056-1065. PMID: 30284751, PMCID: PMC6541538, DOI: 10.1111/adb.12670.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyAging Cohort StudyStrong associationDNA methylation sitesSmoking metricsCohort studyCurrent smokingSmoking statusSpearman correlation coefficientBiomarker cohortBlood samplesSmoking behaviorCriterion standardLogistic regressionSmokingSmoking phenotypesCurve analysisGroup assignmentText notesAssociationDescriptive statisticsPhenotypeCorrelation coefficientGenetic discoveriesPercent
2017
Identification of HIV infection-related DNA methylation sites and advanced epigenetic aging in HIV-positive, treatment-naive U.S. veterans
Nelson KN, Hui Q, Rimland D, Xu K, Freiberg MS, Justice AC, Marconi VC, Sun YV. Identification of HIV infection-related DNA methylation sites and advanced epigenetic aging in HIV-positive, treatment-naive U.S. veterans. AIDS 2017, 31: 571-575. PMID: 27922854, PMCID: PMC5263111, DOI: 10.1097/qad.0000000000001360.Peer-Reviewed Original ResearchConceptsHIV-positive individualsHIV-negative individualsHIV infectionART initiationBlood samplesTreatment-naive HIV-positive individualsVeterans Aging Cohort StudyHIV-negative groupHIV-positive patientsAging Cohort StudyDNAm ageCohort of veteransPeripheral blood samplesNaive HIVAntiretroviral therapyAntiretroviral treatmentCohort studyStudy cohortAge-related diseasesMyocardial infarctionLarge cohortHealthy personsHigh riskHIVU.S. veterans