2024
DNA methylation‐based telomere length is associated with HIV infection, physical frailty, cancer, and all‐cause mortality
Liang X, Aouizerat B, So‐Armah K, Cohen M, Marconi V, Xu K, Justice A. DNA methylation‐based telomere length is associated with HIV infection, physical frailty, cancer, and all‐cause mortality. Aging Cell 2024, 23: e14174. PMID: 38629454, PMCID: PMC11258465, DOI: 10.1111/acel.14174.Peer-Reviewed Original ResearchCancer prevalenceAll-cause mortalityVeterans Aging Cohort Study Biomarker CohortMortality riskPhysiological frailtyVACS IndexIncreased risk of all-cause mortalityRisk of all-cause mortalityCancer registry dataHigher cancer prevalenceHIV infectionElectronic medical recordsSelf-reported raceCoronary heart diseaseAssociated with HIV infectionIndicator of cellular agingPhysical frailtyRegistry dataSmoking statusWomen's Interagency HIV Study cohortAlcohol consumptionShorter TLTelomere lengthMedical recordsPeripheral blood mononuclear cells
2022
Delayed presentation of HIV among older individuals: a growing problem
Justice AC, Goetz MB, Stewart CN, Hogan BC, Humes E, Luz PM, Castilho JL, Nash D, Brazier E, Musick B, Yiannoutsos C, Malateste K, Jaquet A, Cornell M, Shamu T, Rajasuriar R, Jiamsakul A, Althoff KN. Delayed presentation of HIV among older individuals: a growing problem. The Lancet HIV 2022, 9: e269-e280. PMID: 35218732, PMCID: PMC9128643, DOI: 10.1016/s2352-3018(22)00003-0.Peer-Reviewed Original ResearchConceptsLate presentationOlder individualsInternational epidemiology DatabasesAssociation of agePresentation of HIVElectronic medical recordsProportion of peopleEpidemiology DatabaseHIV infectionAIDS (IeDEA) consortiumMedical recordsEffective treatmentAge groupsOlder agePresentationAgeIndividualsHIVInfectionCarePrevention
2020
High concordance between chart review adjudication and electronic medical record data to identify prevalent and incident diabetes mellitus among persons with and without HIV
McGinnis KA, Justice AC, Bailin S, Wellons M, Freiberg M, Koethe JR. High concordance between chart review adjudication and electronic medical record data to identify prevalent and incident diabetes mellitus among persons with and without HIV. Pharmacoepidemiology And Drug Safety 2020, 29: 1432-1439. PMID: 33006179, PMCID: PMC7810212, DOI: 10.1002/pds.5111.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationElectronic medical recordsChart reviewVeterans Aging Cohort Study Biomarker CohortElectronic medical record dataPhysician chart reviewHIV-negative participantsIncident diabetes mellitusICD-9 codesMedical record dataIndication of diabetesPhysician adjudicationIncident diabetesDiabetes mellitusHIV infectionBiomarker cohortHIV statusDiabetes prevalenceMedical recordsMedication recordsLaboratory valuesEpidemiologic studiesDiabetes diagnosisDiagnostic criteriaDiabetes
2019
343. T-cell Subsets Associated with Diabetes in Veterans with and without HIV
Bailin S, McGinnis K, McDonnell W, So-Armah K, Wellons M, Doyle M, Mallal S, Justice A, Freiberg M, Koethe J. 343. T-cell Subsets Associated with Diabetes in Veterans with and without HIV. Open Forum Infectious Diseases 2019, 6: s182-s183. PMCID: PMC6810455, DOI: 10.1093/ofid/ofz360.416.Peer-Reviewed Original ResearchVeterans Aging Cohort StudyT cell subsetsPrevalent diabetesT cellsHIV statusMemory CD4Immune activationNaïve CD8VA electronic medical recordsMultivariate logistic regression modelAdaptive immune activationAdaptive immune profileT effector memoryChronic immune activationEffector memory cellsAging Cohort StudyCentral memory cellsMemory T cellsBody mass indexICD-9 codesPeripheral mononuclear cellsUnhealthy alcohol useElectronic medical recordsLogistic regression modelsRace/ethnicity
2018
Racial disparities in discontinuation of long-term opioid therapy following illicit drug use among black and white patients
Gaither JR, Gordon K, Crystal S, Edelman EJ, Kerns RD, Justice AC, Fiellin DA, Becker WC. Racial disparities in discontinuation of long-term opioid therapy following illicit drug use among black and white patients. Drug And Alcohol Dependence 2018, 192: 371-376. PMID: 30122319, PMCID: PMC7106601, DOI: 10.1016/j.drugalcdep.2018.05.033.Peer-Reviewed Original ResearchConceptsLong-term opioid therapyIllicit drug useUrine drug testsDrug useOpioid therapyWhite racePositive urine drug testDrug testsMonths of treatmentElectronic medical recordsWhite patientsChronic painPatient raceMedical recordsPatientsLogistic regressionOpioidsRacial disparitiesDrug testingCocaineCannabisTherapyCliniciansDiscontinuationPain
2016
Comparison of AUDIT-C collected via electronic medical record and self-administered research survey in HIV infected and uninfected patients
McGinnis KA, Tate JP, Williams EC, Skanderson M, Bryant KJ, Gordon AJ, Kraemer KL, Maisto SA, Crystal S, Fiellin DA, Justice AC. Comparison of AUDIT-C collected via electronic medical record and self-administered research survey in HIV infected and uninfected patients. Drug And Alcohol Dependence 2016, 168: 196-202. PMID: 27694059, PMCID: PMC5086273, DOI: 10.1016/j.drugalcdep.2016.09.015.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useVeterans Aging Cohort StudyAlcohol useClinical screeningElectronic medical record dataHepatitis C infectionAging Cohort StudyMedical record dataElectronic medical recordsUninfected womenC infectionUninfected menUninfected patientsCohort studyMedical recordsUninfected individualsClinical decisionHIVModerate agreementRecord dataEMR dataMenAssess agreementWomenEMR
2013
Agreement Between Electronic Medical Record-based and Self-administered Pain Numeric Rating Scale
Goulet JL, Brandt C, Crystal S, Fiellin DA, Gibert C, Gordon AJ, Kerns RD, Maisto S, Justice AC. Agreement Between Electronic Medical Record-based and Self-administered Pain Numeric Rating Scale. Medical Care 2013, 51: 245-250. PMID: 23222528, PMCID: PMC3572341, DOI: 10.1097/mlr.0b013e318277f1ad.Peer-Reviewed Original ResearchConceptsNumeric rating scaleElectronic medical recordsPain screeningMedical recordsPain numeric rating scaleRating ScaleModerate-severe painVeterans Affairs medical facilitiesPatients' electronic medical recordsMajor depressive disorderEMR dataQuality of careUnderestimation of painSample of veteransPosttraumatic stress disorderHealth care systemClinical characteristicsPatient characteristicsNRS scoresPain careDepressive disorderSurvey scoresPainLevel of agreementStress disorderRisk Factors for Hospitalization and Medical Intensive Care Unit (MICU) Admission Among HIV-Infected Veterans
Akgün KM, Gordon K, Pisani M, Fried T, McGinnis KA, Tate JP, Butt AA, Gibert CL, Huang L, Rodriguez-Barradas MC, Rimland D, Justice AC, Crothers K. Risk Factors for Hospitalization and Medical Intensive Care Unit (MICU) Admission Among HIV-Infected Veterans. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2013, 62: 52-59. PMID: 23111572, PMCID: PMC4182723, DOI: 10.1097/qai.0b013e318278f3fa.Peer-Reviewed Original ResearchConceptsVACS Index scoreMedical intensive care unit admissionIntensive care unit admissionVeterans Aging Cohort StudyCare unit admissionMICU admissionIndex scoreRisk factorsHazardous alcohol useVACS IndexUnit admissionCurrent smokingChronic obstructive pulmonary diseaseAlcohol useNon-AIDS diseasesVA administrative databasesMultivariable Cox regressionSurvival of HIVObstructive pulmonary diseaseAging Cohort StudyElectronic medical recordsAntiretroviral therapyCause mortalityPrior AIDSPrior cancer
2010
A comparison of two approaches to text processing: facilitating chart reviews of radiology reports in electronic medical records.
Womack JA, Scotch M, Gibert C, Chapman W, Yin M, Justice AC, Brandt C. A comparison of two approaches to text processing: facilitating chart reviews of radiology reports in electronic medical records. Perspectives In Health Information Management Is 2010, 7: 1a. PMID: 21063542, PMCID: PMC2966352.Peer-Reviewed Original ResearchComparison of outpatient health care utilization among returning women and men Veterans from Afghanistan and Iraq
Duggal M, Goulet JL, Womack J, Gordon K, Mattocks K, Haskell SG, Justice AC, Brandt CA. Comparison of outpatient health care utilization among returning women and men Veterans from Afghanistan and Iraq. BMC Health Services Research 2010, 10: 175. PMID: 20565985, PMCID: PMC2910695, DOI: 10.1186/1472-6963-10-175.Peer-Reviewed Original ResearchConceptsVA health careOEF/OIF veteransHealth care servicesCare servicesMen veteransOperation Enduring FreedomWomen veteransOIF veteransOperation Iraqi FreedomOutpatient health care utilizationVA electronic medical recordsOutpatient health care servicesVeterans AdministrationSingle VA facilityHealth care utilizationHealth careOutpatient care servicesElectronic medical recordsNonuse of servicesGender differencesRetrospective cohortCare utilizationProspective studyMedical recordsVA facilitiesPatterns of drug use and abuse among aging adults with and without HIV: A latent class analysis of a US Veteran cohort
Green TC, Kershaw T, Lin H, Heimer R, Goulet JL, Kraemer KL, Gordon AJ, Maisto SA, Day NL, Bryant K, Fiellin DA, Justice AC. Patterns of drug use and abuse among aging adults with and without HIV: A latent class analysis of a US Veteran cohort. Drug And Alcohol Dependence 2010, 110: 208-220. PMID: 20395074, PMCID: PMC3087206, DOI: 10.1016/j.drugalcdep.2010.02.020.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyHIV statusMultidrug usersDrug useLatent class analysisUS Veteran cohortAging Cohort StudyActive drug useSelf-reported drug useMental health disordersProblem of obesityElectronic medical recordsUninfected veteransCohort studyClinical variablesDrug use consequencesSocio-demographic covariatesMedical recordsHigh prevalenceUninfected adultsAge 50HIVHealth disordersDrug usersVeteran cohortGender Differences in Rates of Depression, PTSD, Pain, Obesity, and Military Sexual Trauma Among Connecticut War Veterans of Iraq and Afghanistan
Haskell SG, Gordon KS, Mattocks K, Duggal M, Erdos J, Justice A, Brandt CA. Gender Differences in Rates of Depression, PTSD, Pain, Obesity, and Military Sexual Trauma Among Connecticut War Veterans of Iraq and Afghanistan. Journal Of Women's Health 2010, 19: 267-271. PMID: 20109115, PMCID: PMC3052274, DOI: 10.1089/jwh.2008.1262.Peer-Reviewed Original ResearchMeSH KeywordsAdultAfghanistanBody Mass IndexConnecticutCross-Sectional StudiesDepressive DisorderFemaleHumansIraqMaleMass ScreeningMilitary PersonnelObesityPainPatient Acceptance of Health CareProcess Assessment, Health CareRapeRetrospective StudiesSex DistributionStress Disorders, Post-TraumaticVeteransConceptsPosttraumatic stress disorderMilitary sexual traumaBody mass indexFemale veteransHealth clinicsPositive screeningVA Connecticut Healthcare SystemVeterans Affairs Healthcare SystemSignificant pain scoresWomen's health clinicHealthcare systemOEF/OIF veteransRates of depressionSexual traumaElectronic medical recordsGender differencesOperation Enduring Freedom/Operation Iraqi FreedomVA ConnecticutPain scoresChronic painMass indexCross-sectional data analysisPrimary careMedical recordsMale veterans
2009
Erectile Dysfunction Drug Receipt, Risky Sexual Behavior and Sexually Transmitted Diseases in HIV-infected and HIV-uninfected Men
Cook RL, McGinnis KA, Samet JH, Fiellin DA, Rodriquez-Barradas M, Kraemer KL, Gibert CL, Braithwaite RS, Goulet JL, Mattocks K, Crystal S, Gordon AJ, Oursler KK, Justice AC. Erectile Dysfunction Drug Receipt, Risky Sexual Behavior and Sexually Transmitted Diseases in HIV-infected and HIV-uninfected Men. Journal Of General Internal Medicine 2009, 25: 115-121. PMID: 19921112, PMCID: PMC2837496, DOI: 10.1007/s11606-009-1164-9.Peer-Reviewed Original ResearchConceptsErectile dysfunction drugsRisky sexual behaviorSexual behaviorUnprotected sexAdministrative pharmacy dataMinority of HIVUnknown HIV statusSample of HIVPercent of menElectronic medical recordsThousand seven hundredUninfected menHIV statusOutpatient clinicMore prescriptionsPharmacy dataMedical recordsCharacteristics of menPrevention interventionsCare providersDrug receiptHIVMultivariate analysisSubstance usersSeven hundredDevelopment of an Electronic Medical Record-Based Clinical Decision Support Tool to Improve HIV Symptom Management
Nader CM, Tsevat J, Justice AC, Mrus JM, Levin F, Kozal MJ, Mattocks K, Farber S, Rogers M, Erdos J, Brandt C, Kudel I, Braithwaite R. Development of an Electronic Medical Record-Based Clinical Decision Support Tool to Improve HIV Symptom Management. AIDS Patient Care And STDs 2009, 23: 521-529. PMID: 19538046, PMCID: PMC3048777, DOI: 10.1089/apc.2008.0209.Peer-Reviewed Original ResearchMeSH KeywordsAdultDecision Making, Computer-AssistedDecision Support Systems, ClinicalFemaleHIV InfectionsHumansMaleMedical Records Systems, ComputerizedMiddle AgedPatient SatisfactionPilot ProjectsPractice Guidelines as TopicPractice Patterns, Physicians'Severity of Illness IndexSurveys and QuestionnairesUnited StatesUnited States Department of Veterans AffairsConceptsClinical decision support toolVeterans Health Administration electronic medical recordsElectronic medical recordsSymptom managementMedical recordsProvider awarenessProgress notesClinical HIV careHIV symptom managementEMR notesHIV careHIV clinicClinical responseControl patientsHIV diseaseCommon symptomsPoint of careHIV symptomsProvider notesPatients' perceptionsIntervention groupIntervention periodCare plansPatientsSymptoms
2008
Impact of Pneumococcal Vaccination on the Incidence of Pneumonia by HIV Infection Status among Patients Enrolled in the Veterans Aging Cohort 5-Site Study
Rodriguez-Barradas MC, Goulet J, Brown S, Goetz MB, Rimland D, Simberkoff MS, Crothers K, Justice AC. Impact of Pneumococcal Vaccination on the Incidence of Pneumonia by HIV Infection Status among Patients Enrolled in the Veterans Aging Cohort 5-Site Study. Clinical Infectious Diseases 2008, 46: 1093-1100. PMID: 18444830, PMCID: PMC3115628, DOI: 10.1086/529201.Peer-Reviewed Original ResearchConceptsPneumococcal polysaccharide vaccineVeterans Aging CohortPPV vaccinationIncidence of pneumoniaAging CohortCox proportional hazards regression methodsLow CD4 cell countsProportional hazards regression methodsCD4 cell countHIV infection statusRisk of pneumoniaLower hemoglobin levelsBenefits of vaccinationHuman immunodeficiency virusOngoing prospective studyElectronic medical recordsPneumococcal vaccinationPneumonia eventsUnvaccinated patientsCurrent smokingPneumococcal diseasePolysaccharide vaccineVaccination statusHIV infectionRetrospective review
2007
Decreased Awareness of Current Smoking Among Health Care Providers of HIV-positive Compared to HIV-negative Veterans
Crothers K, Goulet JL, Rodriguez-Barradas MC, Gibert CL, Butt AA, Braithwaite RS, Peck R, Justice AC. Decreased Awareness of Current Smoking Among Health Care Providers of HIV-positive Compared to HIV-negative Veterans. Journal Of General Internal Medicine 2007, 22: 749-754. PMID: 17503106, PMCID: PMC2219870, DOI: 10.1007/s11606-007-0158-8.Peer-Reviewed Original ResearchConceptsHIV providersCurrent smokingSmoking cessationCough/dyspneaHIV-negative patientsHIV-negative veteransCombination antiretroviral therapyHIV-positive patientsHIV viral suppressionPatient's HIV statusImportant risk factorHealth care providersElectronic medical recordsBackgroundCigarette smokingAntiretroviral therapyComorbid illnessesViral suppressionComorbid diseasesCurrent smokersIndependent predictorsProvider questionnairesHIV statusVA databasesPatient populationImmune competenceMeasuring Performance Directly Using the Veterans Health Administration Electronic Medical Record
Goulet JL, Erdos J, Kancir S, Levin FL, Wright SM, Daniels SM, Nilan L, Justice AC. Measuring Performance Directly Using the Veterans Health Administration Electronic Medical Record. Medical Care 2007, 45: 73-79. PMID: 17279023, PMCID: PMC3460379, DOI: 10.1097/01.mlr.0000244510.09001.e5.Peer-Reviewed Original ResearchConceptsExternal Peer Review ProgramElectronic medical record systemChart reviewVeterans Health Administration electronic medical recordsEMR dataExtensive chart reviewCross-sectional studySite of careElectronic medical recordsClinical performance measuresMedical record systemMost patientsMedical recordsAnalyzable dataPatientsPeer review programCut pointsRecord systemReview programCareLittle evidenceLarge proportionReviewMeasures
2006
Increased COPD Among HIV-Positive Compared to HIV-Negative Veterans
Crothers K, Butt AA, Gibert CL, Rodriguez-Barradas MC, Crystal S, Justice AC, Team F. Increased COPD Among HIV-Positive Compared to HIV-Negative Veterans. CHEST Journal 2006, 130: 1326-1333. PMID: 17099007, DOI: 10.1378/chest.130.5.1326.Peer-Reviewed Original ResearchConceptsInjection drug usePrevalence of COPDHIV-negative subjectsIndependent risk factorHIV infectionICD-9 codesRisk factorsDiagnostic codesAlcohol abuseICD-9 diagnostic codesHIV-negative veteransActive antiretroviral therapyHIV-positive patientsEra of HAARTHIV-negative menHIV-positive subjectsProspective observational studyPathogenesis of COPDRisk of COPDHealth care providersElectronic medical recordsRace/ethnicityAntiretroviral therapyHIV-positiveCigarette smokingDevelopment and Verification of a “Virtual” Cohort Using the National VA Health Information System
Fultz SL, Skanderson M, Mole LA, Gandhi N, Bryant K, Crystal S, Justice AC. Development and Verification of a “Virtual” Cohort Using the National VA Health Information System. Medical Care 2006, 44: s25-s30. PMID: 16849965, DOI: 10.1097/01.mlr.0000223670.00890.74.Peer-Reviewed Original ResearchConceptsPositive predictive valueIntegrated electronic medical recordsOutpatient codesPredictive valueCohort of veteransVA administrative dataElectronic medical recordsAdministrative dataMajority of subjectsInpatient codesSimilar HIVHAART eraHIV infectionCase RegistryPharmacy benefit managementPharmacy dataMedical recordsClinical dataLarge cohortConfirmatory laboratoryIndependent clinical dataHIVHealth information systemsVirtual cohortCohort
2005
Relationship between provider type and the attainment of treatment goals in primary care.
Federman DG, Krishnamurthy R, Kancir S, Goulet J, Justice A. Relationship between provider type and the attainment of treatment goals in primary care. The American Journal Of Managed Care 2005, 11: 561-6. PMID: 16159046.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseProvider typeArtery diseaseBlood pressureDiabetes mellitusTreatment goalsRecent low-density lipoprotein cholesterol levelsLow-density lipoprotein cholesterol levelsAdditional patient characteristicsBlood pressure goalsGoal blood pressureLipoprotein cholesterol levelsClinical Modification codesTreatment of dyslipidemiaTreatment of hypertensionElectronic medical recordsHealth care systemInternal medicine residentsPatient agePatient characteristicsHemoglobin levelsNinth RevisionPrimary careCholesterol levelsMedical records