Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program
Serper M, Vujkovic M, Kaplan DE, Carr RM, Lee KM, Shao Q, Miller DR, Reaven PD, Phillips LS, O’Donnell C, Meigs JB, Wilson PWF, Vickers-Smith R, Kranzler HR, Justice AC, Gaziano JM, Muralidhar S, Pyarajan S, DuVall SL, Assimes TL, Lee JS, Tsao PS, Rader DJ, Damrauer SM, Lynch JA, Saleheen D, Voight BF, Chang KM, . Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program. PLOS ONE 2020, 15: e0237430. PMID: 32841307, PMCID: PMC7447043, DOI: 10.1371/journal.pone.0237430.Peer-Reviewed Original ResearchMeSH Keywords17-Hydroxysteroid DehydrogenasesAbdomenAdaptor Proteins, Signal TransducingAgedAlanine TransaminaseElectronic Health RecordsFemaleGenetic LociGenetic Predisposition to DiseaseGenetic VariationHumansLipaseLiverLysophospholipaseMaleMembrane ProteinsMiddle AgedNon-alcoholic Fatty Liver DiseasePhenotypeRisk FactorsVeteransConceptsMetabolic risk factorsNAFLD phenotypeAlanine aminotransferaseUnits/LElectronic health recordsAdvanced fibrosisRisk factorsMillion Veteran ProgramAlcohol consumptionNon-invasive criteriaNormal alanine aminotransferaseNAFLD fibrosis scorePopulation-based studyGenetic variantsFatty liver phenotypeVeteran ProgramPNPLA3 locusNAFLD riskLiver biopsyLiver diseaseFibrosis scoreEHR reviewUS veteransBiopsy dataAbdominal imagingFIB-4 stage of liver fibrosis is associated with incident heart failure with preserved, but not reduced, ejection fraction among people with and without HIV or hepatitis C
So-Armah KA, Lim JK, Re V, Tate JP, Chang CH, Butt AA, Gibert CL, Rimland D, Marconi VC, Goetz MB, Ramachandran V, Brittain E, Long M, Nguyen KL, Rodriguez-Barradas MC, Budoff MJ, Tindle HA, Samet JH, Justice AC, Freiberg MS, Team V. FIB-4 stage of liver fibrosis is associated with incident heart failure with preserved, but not reduced, ejection fraction among people with and without HIV or hepatitis C. Progress In Cardiovascular Diseases 2020, 63: 184-191. PMID: 32068085, PMCID: PMC7278895, DOI: 10.1016/j.pcad.2020.02.010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsFemaleHealth StatusHeart FailureHepatitis CHIV InfectionsHIV Long-Term SurvivorsHumansIncidenceLiver CirrhosisMaleMiddle AgedPrognosisRisk AssessmentRisk FactorsSeverity of Illness IndexStroke VolumeTime FactorsUnited StatesVentricular Function, LeftVeterans HealthViral LoadConceptsType of HFIncident heart failureHeart failureHepatitis C statusAdvanced fibrosisLiver fibrosisEjection fractionHazard ratioC statusVeterans Aging Cohort StudyRisk of HFpEFLast clinic visitReduced ejection fractionAging Cohort StudyLiver fibrosis scoresPrevalent cardiovascular diseaseFirst HF eventProportional hazards modelIncident HFpEFHepatitis CClinic visitsCohort studyPrimary outcomeFibrosis scoreHF events