2023
MULTI-ANCESTRY META-ANALYSIS OF TOBACCO USE DISORDERS PRIORITIZES NOVEL CANDIDATE RISK GENES AND REVEALS ASSOCIATIONS WITH NUMEROUS HEALTH OUTCOMES
Sanchez-Roige S, Toikumo S, Jennings M, Pham B, Lee H, Mallard T, Bianchi S, Meredith J, Smoller J, Davis L, Justice A, Kranzler H, Kember R, Sanchez-Roige S. MULTI-ANCESTRY META-ANALYSIS OF TOBACCO USE DISORDERS PRIORITIZES NOVEL CANDIDATE RISK GENES AND REVEALS ASSOCIATIONS WITH NUMEROUS HEALTH OUTCOMES. European Neuropsychopharmacology 2023, 75: s8-s9. DOI: 10.1016/j.euroneuro.2023.08.024.Peer-Reviewed Original ResearchTobacco use disorderUse disordersPrevalent substance use disordersSubstance use disordersRisk genesNumerous health outcomesHIV infectionHeart diseaseSmoking behaviorMedical outcomesGenome-wide association studiesNicotine consumptionHealth outcomesCandidate risk genesPotential risk genesGenetic factorsIndependent risk lociDisordersRisk variantsNovel candidate risk genesRisk lociOutcomesMajority of variantsFunctional genomics toolsPsychiatric traits
2021
Twelve-Month Retention in Opioid Agonist Treatment for Opioid Use Disorder Among Patients With and Without HIV
Wyse JJ, McGinnis KA, Edelman EJ, Gordon AJ, Manhapra A, Fiellin DA, Moore BA, Korthuis PT, Kennedy AJ, Oldfield BJ, Gaither JR, Gordon KS, Skanderson M, Barry DT, Bryant K, Crystal S, Justice AC, Kraemer KL. Twelve-Month Retention in Opioid Agonist Treatment for Opioid Use Disorder Among Patients With and Without HIV. AIDS And Behavior 2021, 26: 975-985. PMID: 34495424, PMCID: PMC8840957, DOI: 10.1007/s10461-021-03452-0.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyOpioid use disorderVeterans Aging Cohort StudyHIV statusUse disordersOpioid agonist treatmentAging Cohort StudyDiagnosis of HCVTwelve-month retentionPositive health outcomesOAT retentionAgonist therapyCohort studyHIV managementAgonist treatmentPredictors of retentionPatientsHealth outcomesHistory of homelessnessHIVLower likelihoodImproved likelihoodLikelihood of initiationBuprenorphineDisordersImpact of intensity of behavioral treatment, with or without medication treatment, for opioid use disorder on HIV outcomes in persons with HIV
Kennedy AJ, McGinnis KA, Merlin JS, Edelman EJ, Gordon AJ, Korthuis PT, Skanderson M, Williams EC, Wyse J, Oldfield B, Bryant K, Justice A, Fiellin DA, Kraemer KL. Impact of intensity of behavioral treatment, with or without medication treatment, for opioid use disorder on HIV outcomes in persons with HIV. Journal Of Substance Use And Addiction Treatment 2021, 132: 108509. PMID: 34130128, PMCID: PMC8628025, DOI: 10.1016/j.jsat.2021.108509.Peer-Reviewed Original ResearchConceptsOpioid use disorderVACS Index 2.0Viral loadMOUD receiptART initiationCD4 countART adherenceUse disordersVeterans Aging Cohort Study (VACS) dataBehavioral treatmentHIV clinical outcomesLog viral loadCD4 cell countAntiretroviral treatment initiationCohort study dataPoor health outcomesPre-post changesHIV outcomesTreatment initiationClinical outcomesMedication treatmentMOUD treatmentPWHHealth outcomesCell count
2019
Predictors of timely opioid agonist treatment initiation among veterans with and without HIV
Wyse JJ, Robbins JL, McGinnis KA, Edelman EJ, Gordon AJ, Manhapra A, Fiellin DA, Moore BA, Korthuis PT, Gaither JR, Gordon K, Skanderson M, Barry DT, Crystal S, Justice A, Kraemer KL. Predictors of timely opioid agonist treatment initiation among veterans with and without HIV. Drug And Alcohol Dependence 2019, 198: 70-75. PMID: 30878769, PMCID: PMC6836871, DOI: 10.1016/j.drugalcdep.2019.01.038.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyOpioid use disorderVeterans Aging Cohort StudyOAT initiationUninfected patientsClinical encountersNational observational cohortAging Cohort StudyAfrican American patientsImproved health outcomesAgonist therapyCohort studyObservational cohortTreatment initiationPredictive factorsEffective treatmentAdjusted modelUninfected controlsUse disordersPsychiatric diagnosisPWHClinical practicePatientsHealth outcomesRural residence
2018
Nonantiretroviral polypharmacy and adverse health outcomes among HIV-infected and uninfected individuals
Justice AC, Gordon KS, Skanderson M, Edelman EJ, Akgün KM, Gibert CL, Re V, Rimland D, Womack JA, Wyatt CM, Tate JP, Team V. Nonantiretroviral polypharmacy and adverse health outcomes among HIV-infected and uninfected individuals. AIDS 2018, 32: 739-749. PMID: 29543653, PMCID: PMC5868488, DOI: 10.1097/qad.0000000000001756.Peer-Reviewed Original ResearchConceptsAdverse health outcomesHIV statusUninfected individualsVACS IndexMedication countUS Veterans Affairs Healthcare SystemHealth outcomesVeterans Affairs Healthcare SystemRisk of hospitalizationSeverity of illnessHIV-1 RNAHIV-positive individualsRisk of mortalityDose responseRace/ethnicityPolypharmacyFiscal year 2009HospitalizationMedicationsMortalityHealthcare systemAntiretroviralsOutcomesAssociationRisk
2017
DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty
Zhang X, Hu Y, Justice AC, Li B, Wang Z, Zhao H, Krystal JH, Xu K. DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty. Nature Communications 2017, 8: 2243. PMID: 29269866, PMCID: PMC5740109, DOI: 10.1038/s41467-017-02326-1.Peer-Reviewed Original ResearchConceptsIllicit drug injectionHepatitis C infectionWhite blood cellsIllicit drug useCo-occurring conditionsMethylation signaturesDiscovery sampleC infectionHepatitis CEpigenome-wide association analysisLower frailtyDrug injectionHigh frailtyImmune functionHealth outcomesDrug useFrailtyDNA methylation signaturesBlood cellsHIVReplication sampleEpigenetic programmingSignificant CpGsEpigenetic effectsIndividualsMistrust and Endorsement of Human Immunodeficiency Virus Conspiracy Theories Among Human Immunodeficiency Virus–Infected African American Veterans
Mattocks KM, Gibert C, Fiellin D, Fiellin LE, Jamison A, Brown A, Justice AC. Mistrust and Endorsement of Human Immunodeficiency Virus Conspiracy Theories Among Human Immunodeficiency Virus–Infected African American Veterans. Military Medicine 2017, 182: e2073-e2079. PMID: 29087885, DOI: 10.7205/milmed-d-17-00078.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHIV conspiracy beliefsAfrican American veteransHealthcare providersHIV treatmentVeterans Health Administration (VHA) careAmerican veteransPoor health outcomesGovernment healthcare providersPhysician mistrustHIV careVHA hospitalsImmunodeficiency virusTreatment recommendationsMedical conditionsPotential cureHealth outcomesHIV conspiracy theoriesSemistructured interview formatVeterans' willingnessDisproportionate tollRacial disparitiesHealthcare systemVeterans' beliefsVeterans
2016
Higher Time-Updated Body Mass Index
Koethe JR, Jenkins CA, Lau B, Shepherd BE, Wester W, Rebeiro PF, Silverberg MJ, Thorne JE, Gill J, Mayor AM, Willig A, Bosch R, Horberg MA, Justice AC, Sterling TR, Moore RD. Higher Time-Updated Body Mass Index. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2016, 73: 197-204. PMID: 27116044, PMCID: PMC5023455, DOI: 10.1097/qai.0000000000001035.Peer-Reviewed Original ResearchConceptsBody mass indexCD4 cell recoveryAntiretroviral therapyCD4 countMass indexNorth American AIDS Cohort CollaborationYears of ARTCell recoveryHigher Body Mass IndexBaseline CD4 countCD4 cell expansionMean CD4 countSuboptimal immune reconstitutionSustained viral suppressionART regimenCohort CollaborationImmune recoveryObese HIVImmune reconstitutionViral suppressionVirologic failureNegative health effectsMultisite cohortPrimary analysisHealth outcomes
2015
Incarceration and health outcomes in HIV‐infected patients: The impact of substance use, primary care engagement, and antiretroviral adherence
Wang EA, McGinnis KA, Long JB, Akgün KM, Edelman EJ, Rimland D, Wang KH, Justice AC, Fiellin DA. Incarceration and health outcomes in HIV‐infected patients: The impact of substance use, primary care engagement, and antiretroviral adherence. American Journal On Addictions 2015, 24: 178-184. PMID: 25662297, PMCID: PMC4397180, DOI: 10.1111/ajad.12177.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyHistory of incarcerationHIV disease outcomeVACS Index scorePrimary care engagementAntiretroviral adherenceCare engagementDisease outcomeIndex scoreDrug useHigher VACS Index scoresHealth of HIVAging Cohort StudyUnhealthy alcohol useViral RNA loadRecent drug useLow CD4Cohort studyRNA loadDrug treatmentHIVHealth outcomesMultivariate analysisMediation analysisPatients
2014
An Adapted Frailty-Related Phenotype and the VACS Index as Predictors of Hospitalization and Mortality in HIV-Infected and Uninfected Individuals
Akgün KM, Tate JP, Crothers K, Crystal S, Leaf DA, Womack J, Brown TT, Justice AC, Oursler KK. An Adapted Frailty-Related Phenotype and the VACS Index as Predictors of Hospitalization and Mortality in HIV-Infected and Uninfected Individuals. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 67: 397-404. PMID: 25202921, PMCID: PMC4213242, DOI: 10.1097/qai.0000000000000341.Peer-Reviewed Original ResearchConceptsHIV-1 RNAUndetectable HIV-1 RNAVACS IndexUninfected individualsHazard ratioC-statisticFrailty-related phenotypePredictors of hospitalizationCohort Study participantsLow physical activityAdverse health outcomesPhysiologic reserveGeriatric syndromesFrailty stateRisk factorsHospitalizationPhysical activityMortality riskHIVHealth behaviorsHealth outcomesSurvival analysisSystem biomarkersStudy participantsMortality
2012
Unhealthy Alcohol and Illicit Drug Use Are Associated With Decreased Quality of HIV Care
Korthuis PT, Fiellin DA, McGinnis KA, Skanderson M, Justice AC, Gordon AJ, Doebler DA, Asch SM, Fiellin LE, Bryant K, Gibert CL, Crystal S, Goetz MB, Rimland D, Rodriguez-Barradas MC, Kraemer KL. Unhealthy Alcohol and Illicit Drug Use Are Associated With Decreased Quality of HIV Care. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2012, 61: 171-178. PMID: 22820808, PMCID: PMC3460799, DOI: 10.1097/qai.0b013e31826741aa.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useIllicit drug useDrug useAlcohol useUnhealthy alcoholHIV careCohort studySubstance useVeterans Aging Cohort StudyRetrospective cohort studyAging Cohort StudySuboptimal health outcomesMultivariable linear regressionSubstance use dataVeteran patientsMean ageMedical recordsMultivariable modelDecreased qualityMAIN OUTCOMEPatientsHealth outcomesHIVMean percentageQuality indicatorsU.S. trends in antiretroviral therapy use, HIV RNA plasma viral loads, and CD4 T-lymphocyte cell counts among HIV-infected persons, 2000 to 2008.
Althoff KN, Buchacz K, Hall HI, Zhang J, Hanna DB, Rebeiro P, Gange SJ, Moore RD, Kitahata MM, Gebo KA, Martin J, Justice AC, Horberg MA, Hogg RS, Sterling TR, Cescon A, Klein MB, Thorne JE, Crane HM, Mugavero MJ, Napravnik S, Kirk GD, Jacobson LP, Brooks JT. U.S. trends in antiretroviral therapy use, HIV RNA plasma viral loads, and CD4 T-lymphocyte cell counts among HIV-infected persons, 2000 to 2008. Annals Of Internal Medicine 2012, 157: 325-35. PMID: 22944874, PMCID: PMC3534765, DOI: 10.7326/0003-4819-157-5-201209040-00005.Peer-Reviewed Original ResearchConceptsCD4 cell countCD4 T-lymphocyte cell countMedian CD4 cell countT-lymphocyte cell countAntiretroviral therapy useHIV VLCell countNA-ACCORDHIV RNATherapy useViral loadU.S. National HIV/AIDS StrategyHealth outcomesNational HIV/AIDS StrategyCanadian HIV Trials NetworkHIV/AIDS StrategyActive antiretroviral therapyHIV outpatient clinicAnnual cross-sectional analysesHIV Cohort StudyProportion of participantsNational surveillance systemRelated health outcomesSimilar demographic characteristicsCross-sectional analysis
2010
HIV/AIDS, comorbidity, and alcohol: can we make a difference?
Justice A, Sullivan L, Fiellin D, . HIV/AIDS, comorbidity, and alcohol: can we make a difference? Alcohol Research 2010, 33: 258-66. PMID: 23584067, PMCID: PMC3711181.BooksConceptsVeterans Aging Cohort StudyHIV infectionLong-term HIV infectionAlcohol useAging Cohort StudyHIV/AIDSAssociated comorbidityCohort studyHIV outcomesMedical managementIntervention trialsAlcohol consumptionHealth outcomesAlcohol treatmentMultisite studyComorbiditiesHIVInfectionOutcomesTreatmentAIDSDiseaseTrialsImportant role