2017
Comparison of dynamic monitoring strategies based on CD4 cell counts in virally suppressed, HIV-positive individuals on combination antiretroviral therapy in high-income countries: a prospective, observational study
Caniglia EC, Cain LE, Sabin CA, Robins JM, Logan R, Abgrall S, Mugavero MJ, Hernández-Díaz S, Meyer L, Seng R, Drozd DR, Seage GR, Bonnet F, Dabis F, Moore RD, Reiss P, van Sighem A, Mathews WC, del Amo J, Moreno S, Deeks SG, Muga R, Boswell SL, Ferrer E, Eron JJ, Napravnik S, Jose S, Phillips A, Justice AC, Tate JP, Gill J, Pacheco A, Veloso VG, Bucher HC, Egger M, Furrer H, Porter K, Touloumi G, Crane H, Miro JM, Sterne JA, Costagliola D, Saag M, Hernán MA, Collaboration H, Systems C. Comparison of dynamic monitoring strategies based on CD4 cell counts in virally suppressed, HIV-positive individuals on combination antiretroviral therapy in high-income countries: a prospective, observational study. The Lancet HIV 2017, 4: e251-e259. PMID: 28411091, PMCID: PMC5492888, DOI: 10.1016/s2352-3018(17)30043-7.Peer-Reviewed Original ResearchConceptsCD4 cell countHIV-positive individualsVirological failureHazard ratioCell countViral loadRisk ratioObservational studyTime-varying CD4 cell countHIV RNA viral loadAntiretroviral therapy regimenCombination antiretroviral therapyRNA viral loadAIDS Research NetworkMortality hazard ratioIntegrated Clinical SystemsHIV-CAUSAL CollaborationLong-term safetyCell count differencesAntiretroviral therapyCD4 countTherapy regimenProspective studyImmunological outcomesClinical guidelines
2007
Adherence, virological and immunological outcomes for HIV-infected veterans starting combination antiretroviral therapies
Braithwaite RS, Kozal MJ, Chang CC, Roberts MS, Fultz SL, Goetz MB, Gibert C, Rodriguez-Barradas M, Mole L, Justice AC. Adherence, virological and immunological outcomes for HIV-infected veterans starting combination antiretroviral therapies. AIDS 2007, 21: 1579-1589. PMID: 17630553, PMCID: PMC3460378, DOI: 10.1097/qad.0b013e3281532b31.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlkynesAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBenzoxazinesCD4 Lymphocyte CountCohort StudiesCyclopropanesDrug Administration ScheduleFemaleHIV InfectionsHIV-1HumansMaleMiddle AgedPatient ComplianceReverse Transcriptase InhibitorsRNA, ViralTreatment OutcomeVeteransViral LoadConceptsPrevious antiretroviral exposureSingle PI regimensCombination ARTImmunological outcomesAntiretroviral exposureHIV RNAPI regimensProtease inhibitorsCombination antiretroviral therapy regimenHIV-RNA viral suppressionTreatment assignmentVeterans Affairs Healthcare SystemEfavirenz-based regimenGreater adherence levelsLog HIV RNAAntiretroviral therapy regimenBaseline clinical characteristicsCD4 cell countCombination antiretroviral therapyPharmacy refill recordsOutcome one yearAntiretroviral prescriptionsAntiretroviral regimensEfavirenz regimensNevirapine regimens