2022
Statins Utilization in Adults With HIV: The Treatment Gap and Predictors of Statin Initiation
Coburn SB, Lang R, Zhang J, Palella FJ, Horberg MA, Castillo-Mancilla J, Gebo K, Galaviz KI, Gill MJ, Silverberg MJ, Hulgan T, Elion RA, Justice AC, Moore RD, Althoff KN, Research and Design of IeDEA F. Statins Utilization in Adults With HIV: The Treatment Gap and Predictors of Statin Initiation. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2022, 91: 469-478. PMID: 36053091, PMCID: PMC9649872, DOI: 10.1097/qai.0000000000003083.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiovascular DiseasesEligibility DeterminationHIV InfectionsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsRacial GroupsConceptsACC/AHA guidelinesStatin initiationStatin eligibilityAHA guidelinesTreatment gapNorth American AIDS Cohort CollaborationATP III guidelinesCohort CollaborationPrevalence ratiosUS cohortStatin utilizationEligibility criteriaStatinsPoisson regressionConfidence intervalsAnnual proportionHIVPWHEligibilityAppropriate candidatesCalendar yearPredictorsGuidelinesInitiationCohort
2021
Statin exposure and risk of cancer in people with and without HIV infection.
Bedimo RJ, Park LS, Shebl FM, Sigel K, Rentsch CT, Crothers K, Rodriguez-Barradas MC, Goetz MB, Butt AA, Brown ST, Gibert C, Justice AC, Tate JP. Statin exposure and risk of cancer in people with and without HIV infection. AIDS 2021, 35: 325-334. PMID: 33181533, PMCID: PMC7775280, DOI: 10.1097/qad.0000000000002748.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesFemaleHIV InfectionsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleNeoplasmsProportional Hazards ModelsConceptsVeterans Aging Cohort StudyStatin useStatin exposureHazard ratioCancer riskLower riskPropensity score-matched cohortCox regression hazard ratiosAging Cohort StudyAnti-inflammatory effectsRegression hazard ratiosNon-Hodgkin lymphomaConfidence intervalsCancer registry linkagePropensity score-matched sampleRisk of cancerDeath overallUninfected patientsCohort studyIncident cancerRegistry linkageHIV infectionHIV statusStatin initiatorsUninfected persons
2017
Risk of Acute Liver Injury After Statin Initiation by Human Immunodeficiency Virus and Chronic Hepatitis C Virus Infection Status
Byrne DD, Tate JP, Forde KA, Lim JK, Goetz MB, Rimland D, Rodriguez-Barradas MC, Butt AA, Gibert CL, Brown ST, Bedimo R, Freiberg MS, Justice AC, Kostman JR, Roy JA, Re V. Risk of Acute Liver Injury After Statin Initiation by Human Immunodeficiency Virus and Chronic Hepatitis C Virus Infection Status. Clinical Infectious Diseases 2017, 65: 1542-1550. PMID: 29020184, PMCID: PMC5850026, DOI: 10.1093/cid/cix564.Peer-Reviewed Original ResearchMeSH KeywordsChemical and Drug Induced Liver InjuryFemaleHepatitis C, ChronicHIV InfectionsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceMaleMiddle AgedRetrospective StudiesRisk FactorsConceptsSevere acute liver injuryAcute liver injuryHuman immunodeficiency virusStatin initiatorsLower riskHCV statusCohort studyHazard ratioStatin nonusersLiver injuryUninfected personsImmunodeficiency virusChronic hepatitis C virus (HCV) infectionHepatitis C virus (HCV) infection statusHIV/HCV-coinfected patientsPropensity score-adjusted hazard ratiosHIV/HCV statusHepatitis C virus infectionVeterans Aging Cohort StudyC virus infectionAging Cohort StudyConfidence intervalsVirus infection statusDevelopment of liverAminotransferase elevation
2014
HIV infection, antiretroviral therapy initiation and longitudinal changes in biomarkers of organ function.
So-Armah KA, Chang J, Alcorn C, Lo Re V, Baker JV, Tracy R, Butt AA, Agan BK, Rimland D, Gibert CL, Goetz MB, Oursler KK, Rodriguez-Barradas MC, Kuller LH, Brown ST, Stein JH, Skanderson M, Justice AC, Freiberg MS. HIV infection, antiretroviral therapy initiation and longitudinal changes in biomarkers of organ function. Current HIV Research 2014, 12: 50-9. PMID: 25034208, PMCID: PMC4495647, DOI: 10.2174/1570162x1201140716101512.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsBiomarkersBlood GlucoseBlood PressureCD4 Lymphocyte CountDiabetes MellitusFemaleHepatitis CHIV InfectionsHIV-1HumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypertensionKidney DiseasesLipidsLiver DiseasesLongitudinal StudiesMaleMiddle AgedRNA, ViralVeteransConceptsART initiationHIV infectionHIV infection levelsViral suppressionLongitudinal changesLDL cholesterolPositive HIV antibody testBiomarker measurementsAge-related chronic diseasesAntiretroviral therapy initiationEnd-organ diseaseFIB-4 scoreHIV antibody testWilcoxon signedrank testUninfected veteransVACS-VCFIB-4Therapy initiationHIV levelsHDL cholesterolSerum levelsTotal cholesterolPlatelet countMean ageChronic diseases