2022
Epigenetic Age Acceleration Markers Are Associated With Physiologic Frailty and All-Cause Mortality in People With Human Immunodeficiency Virus
Oursler KK, Marconi VC, Wang Z, Xu K, Montano M, So-Armah K, Justice AC, Sun YV. Epigenetic Age Acceleration Markers Are Associated With Physiologic Frailty and All-Cause Mortality in People With Human Immunodeficiency Virus. Clinical Infectious Diseases 2022, 76: e638-e644. PMID: 35970820, PMCID: PMC10169393, DOI: 10.1093/cid/ciac656.Peer-Reviewed Original ResearchMeSH KeywordsAgingCohort StudiesEpigenesis, GeneticFemaleFrailtyHIVHIV InfectionsHumansMaleMiddle AgedConceptsHuman immunodeficiency virusPhysiologic frailtyVACS IndexCause mortalityMortality discriminationImmunodeficiency virusAge accelerationEpigenetic age accelerationVeterans Aging Cohort Study (VACS) IndexWhite blood cell samplesVACS Index 2.0VACS Index scoreNon-Hispanic blacksIntrinsic epigenetic age accelerationExtrinsic epigenetic age accelerationEpigenome-wide DNA methylationBlood cell samplesHazard ratioOne-year increaseCox regressionMean ageC-statisticIndex scoreMortalityStudy indicesSoluble CD14-associated DNA methylation sites predict mortality among men with HIV infection
Titanji BK, Wang Z, Chen J, Hui Q, So-Armah K, Freiberg M, Justice AC, Ke X, Marconi VC, Sun YV. Soluble CD14-associated DNA methylation sites predict mortality among men with HIV infection. AIDS 2022, 36: 1563-1571. PMID: 35979830, PMCID: PMC9394925, DOI: 10.1097/qad.0000000000003279.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesDNA MethylationEpigenesis, GeneticGenome-Wide Association StudyHIV InfectionsHumansInflammationLipopolysaccharide ReceptorsMaleConceptsVeterans Aging Cohort StudyAging Cohort StudyElevated plasma levelsCox regression modelUnderstanding of prognosisPeripheral blood samplesPotential therapeutic targetEpigenome-wide association studiesMultiple testingCause mortalitySCD14 levelsCohort studyHIV infectionPlasma levelsSoluble CD14Disease progressionImmune functionSurvival timeBlood samplesSCD14Therapeutic targetPWHAntiviral responseSignificant associationDNAm sitesA new monocyte epigenetic clock reveals nonlinear effects of alcohol consumption on biological aging in three independent cohorts (N = 2242)
Liang X, Sinha R, Justice AC, Cohen MH, Aouizerat BE, Xu K. A new monocyte epigenetic clock reveals nonlinear effects of alcohol consumption on biological aging in three independent cohorts (N = 2242). Alcohol Clinical And Experimental Research 2022, 46: 736-748. PMID: 35257385, PMCID: PMC9117474, DOI: 10.1111/acer.14803.Peer-Reviewed Original ResearchMeSH KeywordsAgingAlcohol DrinkingCohort StudiesDNA MethylationEpigenesis, GeneticFemaleHumansMonocytes
2019
Epigenetic Associations With Estimated Glomerular Filtration Rate Among Men With Human Immunodeficiency Virus Infection
Chen J, Huang Y, Hui Q, Mathur R, Gwinn M, So-Armah K, Freiberg MS, Justice AC, Xu K, Marconi VC, Sun YV. Epigenetic Associations With Estimated Glomerular Filtration Rate Among Men With Human Immunodeficiency Virus Infection. Clinical Infectious Diseases 2019, 70: 667-673. PMID: 30893429, PMCID: PMC7319269, DOI: 10.1093/cid/ciz240.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionGlomerular filtration rateKidney functionFiltration rateVirus infectionVeterans Aging Cohort StudyPeripheral blood mononuclear cellsAging Cohort StudyHIV-positive participantsBlood mononuclear cellsMechanisms of HIVCKD riskCohort studyKidney diseaseMononuclear cellsHigh riskHIVPooled populationEGFREpigenetic associationsSignificant CpG sitesGuanine dinucleotide sitesPotential epigenetic mechanismsDNA Methylation Markers of Type 2 Diabetes Mellitus Among Male Veterans With or Without Human Immunodeficiency Virus Infection
Mathur R, Hui Q, Huang Y, Gwinn M, So-Armah K, Freiberg MS, Justice AC, Xu K, Marconi VC, Sun YV. DNA Methylation Markers of Type 2 Diabetes Mellitus Among Male Veterans With or Without Human Immunodeficiency Virus Infection. The Journal Of Infectious Diseases 2019, 219: 1959-1962. PMID: 30649532, PMCID: PMC6534194, DOI: 10.1093/infdis/jiz023.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionHIV infection statusImmunodeficiency virus infectionVirus infectionVeterans Aging Cohort StudyType 2 diabetes mellitusInfection statusPancreatic β-cell functionAging Cohort StudyΒ-cell functionCohort studyDiabetes mellitusT2DM pathogenesisMale veteransType 2DNA methylation markersSuggestive interactionStatistical significanceMale participantsMellitusT2DMMethylation markersNovel associationsInfectionSuggestive statistical significance
2018
Machine learning selected smoking-associated DNA methylation signatures that predict HIV prognosis and mortality
Zhang X, Hu Y, Aouizerat BE, Peng G, Marconi VC, Corley MJ, Hulgan T, Bryant KJ, Zhao H, Krystal JH, Justice AC, Xu K. Machine learning selected smoking-associated DNA methylation signatures that predict HIV prognosis and mortality. Clinical Epigenetics 2018, 10: 155. PMID: 30545403, PMCID: PMC6293604, DOI: 10.1186/s13148-018-0591-z.Peer-Reviewed Original ResearchConceptsWhite blood cellsSmoking-associated DNA methylationHIV prognosisInfection-related clinical outcomesBlood cellsSmoking-associated CpGsHIV-positive individualsImmune-related outcomesEpigenome-wide significant CpGsClinical outcomesTobacco smokingVeteran populationSurvival rateDNA methylation indexMortalityFrailtyHIVMethylation indexPrognosisMethylation signaturesDNA methylationOutcomesCell cycleCpGSignificant CpGs
2017
DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty
Zhang X, Hu Y, Justice AC, Li B, Wang Z, Zhao H, Krystal JH, Xu K. DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty. Nature Communications 2017, 8: 2243. PMID: 29269866, PMCID: PMC5740109, DOI: 10.1038/s41467-017-02326-1.Peer-Reviewed Original ResearchConceptsIllicit drug injectionHepatitis C infectionWhite blood cellsIllicit drug useCo-occurring conditionsMethylation signaturesDiscovery sampleC infectionHepatitis CEpigenome-wide association analysisLower frailtyDrug injectionHigh frailtyImmune functionHealth outcomesDrug useFrailtyDNA methylation signaturesBlood cellsHIVReplication sampleEpigenetic programmingSignificant CpGsEpigenetic effectsIndividualsIdentification of HIV infection-related DNA methylation sites and advanced epigenetic aging in HIV-positive, treatment-naive U.S. veterans
Nelson KN, Hui Q, Rimland D, Xu K, Freiberg MS, Justice AC, Marconi VC, Sun YV. Identification of HIV infection-related DNA methylation sites and advanced epigenetic aging in HIV-positive, treatment-naive U.S. veterans. AIDS 2017, 31: 571-575. PMID: 27922854, PMCID: PMC5263111, DOI: 10.1097/qad.0000000000001360.Peer-Reviewed Original ResearchMeSH KeywordsAgingDNA MethylationEpigenesis, GeneticFollow-Up StudiesGenome-Wide Association StudyHIV InfectionsHumansMaleMiddle AgedUnited StatesVeteransConceptsHIV-positive individualsHIV-negative individualsHIV infectionART initiationBlood samplesTreatment-naive HIV-positive individualsVeterans Aging Cohort StudyHIV-negative groupHIV-positive patientsAging Cohort StudyDNAm ageCohort of veteransPeripheral blood samplesNaive HIVAntiretroviral therapyAntiretroviral treatmentCohort studyStudy cohortAge-related diseasesMyocardial infarctionLarge cohortHealthy personsHigh riskHIVU.S. veterans