2021
Polypharmacy-associated risk of hospitalisation among people ageing with and without HIV: an observational study
Justice AC, Gordon KS, Romero J, Edelman EJ, Garcia BJ, Jones P, Khoo S, Re V, Rentsch CT, Tate JP, Tseng A, Womack J, Jacobson D. Polypharmacy-associated risk of hospitalisation among people ageing with and without HIV: an observational study. The Lancet Healthy Longevity 2021, 2: e639-e650. PMID: 34870254, PMCID: PMC8639138, DOI: 10.1016/s2666-7568(21)00206-3.Peer-Reviewed Original ResearchMeSH KeywordsAgingCohort StudiesFemaleFrailtyHIV InfectionsHIV SeropositivityHospitalizationHumansMalePolypharmacyConceptsVeterans Aging Cohort StudyMedication countDrug-drug interactionsAntiretroviral therapyObservational studyPhysiological frailtyVeterans Affairs Health Services ResearchMore drug-drug interactionsRisk of hospitalisationRisk of admissionAging Cohort StudyHIV-1 RNANon-ART medicationsAdverse health outcomesNational InstituteHealth services researchAdditional medicationObserved medicationActive medicationCause mortalityMore medicationsCohort studyPrescription fillsHIV statusPrescription medicationsAssociation between HIV and incident pulmonary hypertension in US Veterans: a retrospective cohort study
Duncan MS, Alcorn CW, Freiberg MS, So-Armah K, Patterson OV, DuVall SL, Crothers KA, Re VL, Butt AA, Lim JK, Kim JW, Tindle HA, Justice AC, Brittain EL. Association between HIV and incident pulmonary hypertension in US Veterans: a retrospective cohort study. The Lancet Healthy Longevity 2021, 2: e417-e425. PMID: 34296203, PMCID: PMC8294078, DOI: 10.1016/s2666-7568(21)00116-1.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesFemaleHIV InfectionsHIV SeropositivityHIV-1HumansHypertension, PulmonaryMaleMiddle AgedRetrospective StudiesVeteransConceptsIncident pulmonary hypertensionHIV viral loadPulmonary artery systolic pressureVeterans Aging Cohort StudyPulmonary hypertension riskPulmonary hypertensionRetrospective cohort studyCohort studyViral loadIncidence rateHypertension incidenceCD4 countHazard ratioHIV statusSystolic pressureHypertension riskHigh riskLow CD4 cell countsHepatitis C virus infectionHigher HIV viral loadChronic obstructive pulmonary diseaseCox proportional hazards regressionC virus infectionCD4 cell countPrevalent heart failure
2017
Risk of End‐Stage Renal Disease in HIV‐Positive Potential Live Kidney Donors
Muzaale AD, Althoff KN, Sperati CJ, Abraham AG, Kucirka LM, Massie AB, Kitahata MM, Horberg MA, Justice AC, Fischer MJ, Silverberg MJ, Butt AA, Boswell SL, Rachlis AR, Mayor AM, Gill MJ, Eron JJ, Napravnik S, Drozd DR, Martin JN, Bosch RJ, Durand CM, Locke JE, Moore RD, Lucas GM, Segev DL. Risk of End‐Stage Renal Disease in HIV‐Positive Potential Live Kidney Donors. American Journal Of Transplantation 2017, 17: 1823-1832. PMID: 28497525, PMCID: PMC5489376, DOI: 10.1111/ajt.14235.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase-Control StudiesFemaleFollow-Up StudiesGlomerular Filtration RateGraft RejectionGraft SurvivalHIV InfectionsHIV SeropositivityHIV-1HumansIncidenceKidney Failure, ChronicKidney Function TestsKidney TransplantationLiving DonorsMaleMiddle AgedNephrectomyNorth AmericaPrognosisRisk FactorsViral LoadConceptsEnd-stage renal diseaseIncidence of ESRDHIV-positive individualsLive kidney donorsKidney donorsRenal diseaseMultivariable Cox proportional hazards regressionCox proportional hazards regressionPotential live kidney donorsHIV-negative peersHIV-negative participantsHIV-positive participantsProportional hazards regressionCopies/mLKidney donor candidatesCumulative incidence estimatesCohort CollaborationCumulative incidenceHIV infectionViral loadHazards regressionNational HealthPositive individualsIncidence estimatesHealth characteristics
2016
Efavirenz versus boosted atazanavir-containing regimens and immunologic, virologic, and clinical outcomes
Cain LE, Caniglia EC, Phillips A, Olson A, Muga R, Pérez-Hoyos S, Abgrall S, Costagliola D, Rubio R, Jarrín I, Bucher H, Fehr J, van Sighem A, Reiss P, Dabis F, Vandenhende MA, Logan R, Robins J, Sterne JAC, Justice A, Tate J, Touloumi G, Paparizos V, Esteve A, Casabona J, Seng R, Meyer L, Jose S, Sabin C, Hernán MA. Efavirenz versus boosted atazanavir-containing regimens and immunologic, virologic, and clinical outcomes. Medicine 2016, 95: e5133. PMID: 27741139, PMCID: PMC5072966, DOI: 10.1097/md.0000000000005133.Peer-Reviewed Original ResearchConceptsCD4 cell countEfavirenz regimenVirologic failureVirologic outcomesSurvival differencesNucleoside reverse transcriptase inhibitor (NRTI) backboneCell countReverse transcriptase inhibitor backboneAtazanavir-containing regimensAIDS-free survivalHuman immunodeficiency virusImmune deficiency syndromeHIV-CAUSAL CollaborationAtazanavir regimenHazard ratioClinical outcomesImmunodeficiency virusProspective studyDeficiency syndromeMean changeRegimensEfavirenzTime-varying covariatesInhibitor backboneRegimen
2015
Medicare and Medicaid enrollment and outside hospitalizations among HIV-infected and uninfected veterans engaged in VA care: a retrospective cohort study
Chang H, Tate J, Justice AC, Ohl ME. Medicare and Medicaid enrollment and outside hospitalizations among HIV-infected and uninfected veterans engaged in VA care: a retrospective cohort study. BMC Health Services Research 2015, 15: 27. PMID: 25608566, PMCID: PMC4307747, DOI: 10.1186/s12913-015-0684-8.Peer-Reviewed Original ResearchConceptsUninfected veteransNon-VA useMedicaid enrollmentVA careLower oddsHealth systemVeterans Administration Health SystemMore frequent hospitalizationsVeterans 65 yearsCohort of HIVRetrospective cohort studyGreater illness severityNon-VA hospitalizationsHigh rateHIV careCohort studyFrequent hospitalizationsHIV infectionHospital admissionIllness severityPoor outcomeWorse outcomesHospitalizationHIVService Medicare
2013
Does Social Isolation Predict Hospitalization and Mortality Among HIV+ and Uninfected Older Veterans?
Greysen SR, Horwitz LI, Covinsky KE, Gordon K, Ohl ME, Justice AC. Does Social Isolation Predict Hospitalization and Mortality Among HIV+ and Uninfected Older Veterans? Journal Of The American Geriatrics Society 2013, 61: 1456-1463. PMID: 23927911, PMCID: PMC3773301, DOI: 10.1111/jgs.12410.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudySocial isolation scoresHuman immunodeficiency virusCause mortalityHospital admissionUninfected groupOlder veteransSocial isolationGreater riskAging Cohort StudyHIV-positive individualsMultivariable regression analysisVA Medical CenterBaseline survey responsesUninfected participantsIncident hospitalizationCohort studyClinical featuresHIV statusImmunodeficiency virusHigh prevalenceMedical CenterMultivariable regressionHospitalizationOlder individualsLifetime Drinking Trajectories Among Veterans in Treatment for HIV
Jacob T, Blonigen DM, Upah R, Justice A. Lifetime Drinking Trajectories Among Veterans in Treatment for HIV. Alcohol Clinical And Experimental Research 2013, 37: 1179-1187. PMID: 23448171, PMCID: PMC5596456, DOI: 10.1111/acer.12071.Peer-Reviewed Original ResearchConceptsSevere chronicHIV diagnosisLate onsetVeterans Aging Cohort StudyYoung adultsCourse of drinkingAging Cohort StudyOnset of HIVOnset of treatmentPatterns of drinkingLifetime Drinking HistoryHIV groupCohort studyHIV- participantsTreatment outcomesHIVCurrent studyYounger ageCocaine useDrinking historyDrinking phasesLatent growth mixture modelMedical issuesLonger durationDrinking trajectories
2012
Heterogeneity in outcomes of treated HIV-positive patients in Europe and North America: relation with patient and cohort characteristics
May MT, Hogg RS, Justice AC, Shepherd BE, Costagliola D, Ledergerber B, Thiébaut R, Gill MJ, Kirk O, van Sighem A, Saag MS, Navarro G, Sobrino-Vegas P, Lampe F, Ingle S, Guest JL, Crane HM, Monforte A, Vehreschild JJ, Sterne J, Collaboration T. Heterogeneity in outcomes of treated HIV-positive patients in Europe and North America: relation with patient and cohort characteristics. International Journal Of Epidemiology 2012, 41: 1807-1820. PMID: 23148105, PMCID: PMC3535877, DOI: 10.1093/ije/dys164.Peer-Reviewed Original ResearchConceptsCompleteness of ascertainmentHIV-positive patientsAntiretroviral therapyMortality rateAdult HIV-positive patientsPrevious AIDS diagnosisRates of AIDSAdjusted mortality rateMortality rate ratiosHigher mortality riskHigh mortality rateDiverse patient cohortCohort heterogeneityCohort CollaborationPatient characteristicsHIV treatmentAIDS diagnosisPatient cohortAdjusted ratesClinical careMortality riskCohort characteristicsPatientsDeath ascertainmentCohortThe effect of efavirenz versus nevirapine-containing regimens on immunologic, virologic and clinical outcomes in a prospective observational study
Cain LE, Phillips A, Lodi S, Sabin C, Bansi L, Justice A, Tate J, Logan R, Robins JM, Sterne JA, van Sighem A, de Wolf F, Bucher HC, Elzi L, Touloumi G, Vourli G, Esteve A, Casabona J, del Amo J, Moreno S, Seng R, Meyer L, Pérez-Hoyos S, Muga R, Abgrall S, Costagliola D, Hernán MA. The effect of efavirenz versus nevirapine-containing regimens on immunologic, virologic and clinical outcomes in a prospective observational study. AIDS 2012, 26: 1691-1705. PMID: 22546987, PMCID: PMC3647467, DOI: 10.1097/qad.0b013e328354f497.Peer-Reviewed Original ResearchConceptsAIDS-free individualsCD4 cell countEfavirenz regimensVirologic failureVirologic outcomesCell countMore nucleoside reverseNevirapine-containing regimensTreat hazard ratiosTypes of regimensProspective observational studyHIV-CAUSAL CollaborationEffect of efavirenzEfavirenz regimenNevirapine regimenNevirapine regimensHazard ratioNucleoside reverseClinical outcomesProspective studyInverse probability weightingLower incidenceObservational studyRegimensLower mortalityLessons learned from the first wave of aging with HIV
Justice AC, Braithwaite RS. Lessons learned from the first wave of aging with HIV. AIDS 2012, 26: s11-s18. PMID: 22781174, PMCID: PMC5596448, DOI: 10.1097/qad.0b013e3283558500.Peer-Reviewed Original ResearchImpact of Antiretroviral Therapy on Tuberculosis Incidence Among HIV-Positive Patients in High-Income Countries
del Amo J, Moreno S, Bucher HC, Furrer H, Logan R, Sterne J, Pérez-Hoyos S, Jarrín I, Phillips A, Lodi S, van Sighem A, de Wolf W, Sabin C, Bansi L, Justice A, Goulet J, Miró JM, Ferrer E, Meyer L, Seng R, Toulomi G, Gargalianos P, Costagliola D, Abgrall S, Hernán MA. Impact of Antiretroviral Therapy on Tuberculosis Incidence Among HIV-Positive Patients in High-Income Countries. Clinical Infectious Diseases 2012, 54: 1364-1372. PMID: 22460971, PMCID: PMC3404691, DOI: 10.1093/cid/cis203.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAnti-HIV AgentsCD4 Lymphocyte CountCohort StudiesDeveloped CountriesDrug Therapy, CombinationEuropeFemaleHIV InfectionsHIV SeropositivityHumansImmune Reconstitution Inflammatory SyndromeIncidenceMaleMiddle AgedMycobacterium tuberculosisPneumocystis cariniiPneumonia, PneumocystisRNA, ViralTuberculosisUnited StatesViral LoadConceptsImmune reconstitution inflammatory syndromeCD4 cell countCells/μL.HIV RNA levelsHazard ratioTuberculosis incidenceCART initiationCell countAntiretroviral therapyTime-varying CD4 cell countBaseline CD4 cell countAIDS-free individualsEffects of CARTLow tuberculosis incidenceMonths of ARTReconstitution inflammatory syndromeHIV-positive patientsRNA levelsHIV-positive individualsHuman immunodeficiency virusHIV-CAUSAL CollaborationInflammatory syndromeImmunodeficiency virusInverse probability weightingPositive individuals
2009
Impact of cigarette smoking on mortality in HIV-positive and HIV-negative veterans.
Crothers K, Goulet JL, Rodriguez-Barradas MC, Gibert CL, Oursler KA, Goetz MB, Crystal S, Leaf DA, Butt AA, Braithwaite RS, Peck R, Justice AC. Impact of cigarette smoking on mortality in HIV-positive and HIV-negative veterans. AIDS Education And Prevention 2009, 21: 40-53. PMID: 19537953, PMCID: PMC3118467, DOI: 10.1521/aeap.2009.21.3_supp.40.Peer-Reviewed Original ResearchConceptsHIV-negative veteransIncidence rate ratiosSmoking statusHIV-negative patientsSimilar mortality riskHIV-positive veteransComorbid diseasesCurrent smokingOverall mortalityCigarette smokingPoor outcomeMortality riskHIVPoisson regressionMortalitySmokingRate ratioVeteransDiseaseStudy of mechanismsLow levelsStatusSmokersPatientsCessationComparison of Two VA Laboratory Data Repositories Indicates That Missing Data Vary Despite Originating From the Same Source
McGinnis KA, Skanderson M, Levin FL, Brandt C, Erdos J, Justice AC. Comparison of Two VA Laboratory Data Repositories Indicates That Missing Data Vary Despite Originating From the Same Source. Medical Care 2009, 47: 121-124. PMID: 19106740, PMCID: PMC3032537, DOI: 10.1097/mlr.0b013e31817d69c2.Peer-Reviewed Original ResearchMeSH KeywordsAlanine TransaminaseAspartate AminotransferasesClinical Laboratory Information SystemsCohort StudiesCreatinineGlycated HemoglobinHealth Care CostsHIV SeropositivityHospitals, VeteransHumansLaboratories, HospitalLeukocytesMedical Records Systems, ComputerizedQuality of Health CareReference StandardsRegistriesResearch DesignSystems IntegrationUnited StatesUnited States Department of Veterans AffairsViral LoadConceptsDecision support systemData repositoryInformation systemsElectronic medical information systemsSupport systemMedical information systemsViral loadCase RegistryHealth information systemsHIV RNA viral loadCD4 lymphocyte countRNA viral loadWhite blood countLaboratory dataVA healthcare systemRepositoryPercent of individualsHIV careLymphocyte countBlood countData variesAlanine aminotransferaseFiscal year 2002Aspartate aminotransferaseVirtual cohort
2008
Factor Structure of Leigh’s (1990) Alcohol Sex Expectancies Scale in Individuals in Treatment for HIV Disease
Maisto SA, McGinnis K, Cook R, Conigliaro J, Bryant K, Justice AC. Factor Structure of Leigh’s (1990) Alcohol Sex Expectancies Scale in Individuals in Treatment for HIV Disease. AIDS And Behavior 2008, 14: 174-180. PMID: 18791863, PMCID: PMC3032495, DOI: 10.1007/s10461-008-9457-2.Peer-Reviewed Original ResearchConceptsHIV groupHIV-positive adultsGeneral medicine clinicSexual risk reductionExcellent internal consistency reliabilityHIV diseaseMedicine clinicInternal consistency reliabilityInfectious diseasesFurther scale refinementHIVReduced inhibitionClinical samplesPrincipal component factor analysisRisk reductionConsistency reliabilityTreatmentDiseaseConstruct validityTotal sampleComponent factor analysisSexMenGroupFactor analysisAn experimental study of the agreement of self-administration and telephone administration of the Timeline Followback interview.
Maisto SA, Conigliaro JC, Gordon AJ, McGinnis KA, Justice AC. An experimental study of the agreement of self-administration and telephone administration of the Timeline Followback interview. Journal Of Studies On Alcohol And Drugs 2008, 69: 468-71. PMID: 18432391, PMCID: PMC3115624, DOI: 10.15288/jsad.2008.69.468.Peer-Reviewed Original ResearchConceptsDaily alcohol consumptionAlcohol consumptionTimeline Followback interviewObservational studyVeterans Aging Cohort StudyHIV-negative adultsHIV-negative individualsHIV-negative menAging Cohort StudyGeneral medicine clinicLarge observational studiesMedian total numberExcellent test-retest reliabilityMultisite observational studyCohort studyTest-retest reliabilityMedicine clinicOngoing longitudinal studyHIVInfectious diseasesTelephone interviewsTelephone administrationClassification of participantsAdministrationSame findings
2006
Increased COPD Among HIV-Positive Compared to HIV-Negative Veterans
Crothers K, Butt AA, Gibert CL, Rodriguez-Barradas MC, Crystal S, Justice AC, Team F. Increased COPD Among HIV-Positive Compared to HIV-Negative Veterans. CHEST Journal 2006, 130: 1326-1333. PMID: 17099007, DOI: 10.1378/chest.130.5.1326.Peer-Reviewed Original ResearchConceptsInjection drug usePrevalence of COPDHIV-negative subjectsIndependent risk factorHIV infectionICD-9 codesRisk factorsDiagnostic codesAlcohol abuseICD-9 diagnostic codesHIV-negative veteransActive antiretroviral therapyHIV-positive patientsEra of HAARTHIV-negative menHIV-positive subjectsProspective observational studyPathogenesis of COPDRisk of COPDHealth care providersElectronic medical recordsRace/ethnicityAntiretroviral therapyHIV-positiveCigarette smokingAlcohol Problems and Health Care Services Use in Human Immunodeficiency Virus (HIV)-Infected and HIV-Uninfected Veterans
Kraemer KL, McGinnis KA, Skanderson M, Cook R, Gordon A, Conigliaro J, Shen Y, Fiellin DA, Justice AC. Alcohol Problems and Health Care Services Use in Human Immunodeficiency Virus (HIV)-Infected and HIV-Uninfected Veterans. Medical Care 2006, 44: s44-s51. PMID: 16849968, DOI: 10.1097/01.mlr.0000223703.91275.78.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlcoholismCohort StudiesFemaleHealth ServicesHIV SeropositivityHumansMaleMiddle AgedProspective StudiesTexasVeteransConceptsHealth care service useCare service useEmergency department visitsHealth service useHuman immunodeficiency virusOutpatient visitsInpatient hospitalizationService useDepartment visitsImmunodeficiency virusEmergency departmentAlcohol problemsInpatient health care utilizationICD-9-CM codesAlcohol-related complicationsMental health visitsHealth care utilizationMedical record databaseGreater outpatientHealth visitsCare utilizationHIV statusIncidence rateAlcohol diagnosisHIVIntoxication Before Intercourse and Risky Sexual Behavior in Male Veterans With and Without Human Immunodeficiency Virus Infection
Cook RL, McGinnis KA, Kraemer KL, Gordon AJ, Conigliaro J, Maisto SA, Samet JH, Crystal S, Rimland D, Bryant KJ, Braithwaite RS, Justice AC. Intoxication Before Intercourse and Risky Sexual Behavior in Male Veterans With and Without Human Immunodeficiency Virus Infection. Medical Care 2006, 44: s31-s36. PMID: 16849966, DOI: 10.1097/01.mlr.0000223710.35008.d9.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesCoitusHIV SeropositivityHumansMaleMiddle AgedPoisoningRisk-TakingSurveys and QuestionnairesVeteransConceptsHIV-positive veteransInconsistent condom useHuman immunodeficiency virus (HIV) infectionHIV-negative veteransImmunodeficiency virus infectionRisky sexual behaviorMale veteransCondom useVirus infectionSexual behaviorSexual partnersVeterans Aging CohortHIV-positive menMeasures of drugMore partnersHIV infectionHIV-positiveOutpatient clinicMeasures of alcoholAging CohortDrug useAlcohol useLast intercourseIntoxicationPast yearAssociations Between Alcohol Use and Homelessness With Healthcare Utilization Among Human Immunodeficiency Virus-Infected Veterans
Gordon AJ, McGinnis KA, Conigliaro J, Rodriguez-Barradas MC, Rabeneck L, Justice AC. Associations Between Alcohol Use and Homelessness With Healthcare Utilization Among Human Immunodeficiency Virus-Infected Veterans. Medical Care 2006, 44: s37-s43. PMID: 16849967, DOI: 10.1097/01.mlr.0000223705.00175.3d.Peer-Reviewed Original ResearchConceptsAlcohol useOutpatient careAlcohol consumptionHealth care service utilizationVA administrative recordsVeterans Aging CohortOutpatient clinic visitsHealth care visitsHuman immunodeficiency virusHealth care providersHomeless HIVCare visitsHIV diseaseClinic visitsCohort studyHealthcare utilizationImmunodeficiency virusService utilizationInpatient utilizationBinge drinkersCare providersAlcohol abuseHazardous drinkersHIVVA hospitalsMedical Disease and Alcohol Use Among Veterans With Human Immunodeficiency Infection
Justice AC, Lasky E, McGinnis KA, Skanderson M, Conigliaro J, Fultz SL, Crothers K, Rabeneck L, Rodriguez-Barradas M, Weissman SB, Bryant K. Medical Disease and Alcohol Use Among Veterans With Human Immunodeficiency Infection. Medical Care 2006, 44: s52-s60. PMID: 16849969, DOI: 10.1097/01.mlr.0000228003.08925.8c.Peer-Reviewed Original ResearchConceptsICD-9 diagnostic codesICD-9 codesChart reviewMedical diseasesDiagnostic codesAlcohol useHepatitis CLevel of exposureHIV infectionAlcohol exposureMultivariate modelGreater exposure levelsCD4 cell countHIV-positive patientsIntravenous drug useObstructive lung diseaseHuman immunodeficiency infectionCurrent alcohol useNonlinearity of associationsDiagnosis of abuseCohort studyBacterial pneumoniaPast drinkersViral loadLung disease