The BCL2-family of protein ligands as cancer drugs: the next generation of therapeutics.
Liu W, Bulgaru A, Haigentz M, Stein CA, Perez-Soler R, Mani S. The BCL2-family of protein ligands as cancer drugs: the next generation of therapeutics. Anti-Cancer Agents In Medicinal Chemistry 2003, 3: 217-23. PMID: 12769779, DOI: 10.2174/1568011033482459.Peer-Reviewed Original ResearchMeSH KeywordsAntimycin AAntineoplastic AgentsApoptosisBenzopyransHumansLigandsModels, MolecularMolecular StructureNeoplasmsNitrilesProto-Oncogene Proteins c-bcl-2Tumor Cells, CulturedConceptsSmall-molecule screening approachFamily of proteinsProcess of apoptosisBCL2 family membersCell suicideOverexpression of BCL2Cellular stressBCL2 familyLigand bindingProtein ligandsBCL2 proteinApoptosisCancer cellsBCL2 overexpressionScreening approachForms of cancerKey mediatorProteinOverexpressionPromising anticancer agentFamily membersCancer drugsCellsAnticancer agentsTherapeutics