2014
Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer
Feng Y, Zhu M, Dangelmajer S, Lee Y, Wijesekera O, Castellanos C, Denduluri A, Chaichana K, Li Q, Zhang H, Levchenko A, Guerrero-Cazares H, Quiñones-Hinojosa A. Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer. Cell Death & Disease 2014, 5: e1567-e1567. PMID: 25501828, PMCID: PMC4649837, DOI: 10.1038/cddis.2014.521.Peer-Reviewed Original ResearchConceptsHuman adipose-derived mesenchymal stem cellsAdipose-derived mesenchymal stem cellsMesenchymal stem cellsBrain tumor-initiating cellsAnti-inflammatory propertiesStem cellsAmyotrophic lateral sclerosisTumor-associated fibroblastsTumor-initiating cellsBrain cancer cellsMyocardial infarctionHypoxic culture conditionsClinical investigationLateral sclerosisLess cell deathBrain cancerMigratory capabilityCancer cellsLow oxygen tensionOxygen tensionRegenerative potentialMultipotent cellsAnticancer propertiesCell deathHypoxia
2002
The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation
Hoffmann A, Levchenko A, Scott M, Baltimore D. The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation. Science 2002, 298: 1241-1245. PMID: 12424381, DOI: 10.1126/science.1071914.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell NucleusChemokine CCL5Chemokine CXCL10Chemokines, CXCComputer SimulationCytoplasmDNA-Binding ProteinsElectrophoretic Mobility Shift AssayFeedback, PhysiologicalGene Expression RegulationHumansI-kappa B ProteinsMiceMice, KnockoutModels, BiologicalNF-kappa BNF-KappaB Inhibitor alphaProto-Oncogene ProteinsSignal TransductionTranscriptional ActivationTumor Cells, CulturedTumor Necrosis Factor-alphaConceptsTranscriptional activator NF-kappaBSelective gene activationKnockout cell linesTemporal controlNF-kappaB inhibitor proteinNF-kappaB responseSignaling modulesCoordinated degradationGene activationMammalian cellsNuclear localizationInhibitor proteinGene expressionIkappaB proteinsSignal-processing characteristicsEpsilon functionNF-kappaB activationCell linesNF-kappaB