Comparison of PCR-based detection of chromogranin A mRNA with traditional histological lymph node staging of small intestinal neuroendocrine neoplasia
Lawrence B, Kenney B, Svejda B, Schimmack S, Alaimo D, Barbieri A, Jedrych J, Kidd M, Modlin I. Comparison of PCR-based detection of chromogranin A mRNA with traditional histological lymph node staging of small intestinal neuroendocrine neoplasia. BMC Research Notes 2012, 5: 318. PMID: 22720672, PMCID: PMC3441285, DOI: 10.1186/1756-0500-5-318.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorCarcinoma, NeuroendocrineChromogranin AFeasibility StudiesHumansImmunohistochemistryIntestinal NeoplasmsIntestine, SmallLymph NodesLymphatic MetastasisNeoplasm MicrometastasisNeoplasm StagingObserver VariationParaffin EmbeddingPredictive Value of TestsReal-Time Polymerase Chain ReactionReproducibility of ResultsRNA, MessengerTissue FixationConceptsLymph nodesCgA mRNALymph node metastasis detectionBenign gastrointestinal diseaseNon-neuroendocrine cancersSmall intestinal NENsDetection of chromograninGreater staging accuracyNode positivityGastrointestinal cancerNeuroendocrine differentiationHistological evidenceGastrointestinal diseasesImmunohistochemical stainingHistological examinationHistological lymphPathological analysisNeuroendocrine neoplasiaTherapeutic strategiesNormal epitheliumStaging accuracyTherapeutic interventionsMetastasis detectionTumor samplesAccurate therapeutic interventions