Featured Publications
Co-option of Neutrophil Fates by Tissue Environments
Ballesteros I, Rubio-Ponce A, Genua M, Lusito E, Kwok I, Fernández-Calvo G, Khoyratty TE, van Grinsven E, González-Hernández S, Nicolás-Ávila JÁ, Vicanolo T, Maccataio A, Benguría A, Li JL, Adrover JM, Aroca-Crevillen A, Quintana JA, Martín-Salamanca S, Mayo F, Ascher S, Barbiera G, Soehnlein O, Gunzer M, Ginhoux F, Sánchez-Cabo F, Nistal-Villán E, Schulz C, Dopazo A, Reinhardt C, Udalova IA, Ng LG, Ostuni R, Hidalgo A. Co-option of Neutrophil Fates by Tissue Environments. Cell 2020, 183: 1282-1297.e18. PMID: 33098771, DOI: 10.1016/j.cell.2020.10.003.Peer-Reviewed Original ResearchConceptsNeutrophil fateDepletion of neutrophilsHematopoietic recoveryVascular repairNeutrophil statesNeutrophil propertiesViral infectionNeutrophilsTarget tissuesHealthy tissueGenotoxic injuryEarly ageMultiple tissuesTissueTissue environmentPhysiological demandsInflammationHematopoietic homeostasisCXCR4LungNon-canonical functionsInjuryCancerInfectionLeukocytes
2024
Embracing cancer complexity: Hallmarks of systemic disease
Swanton C, Bernard E, Abbosh C, André F, Auwerx J, Balmain A, Bar-Sagi D, Bernards R, Bullman S, DeGregori J, Elliott C, Erez A, Evan G, Febbraio M, Hidalgo A, Jamal-Hanjani M, Joyce J, Kaiser M, Lamia K, Locasale J, Loi S, Malanchi I, Merad M, Musgrave K, Patel K, Quezada S, Wargo J, Weeraratna A, White E, Winkler F, Wood J, Vousden K, Hanahan D. Embracing cancer complexity: Hallmarks of systemic disease. Cell 2024, 187: 1589-1616. PMID: 38552609, DOI: 10.1016/j.cell.2024.02.009.Peer-Reviewed Original ResearchConceptsHuman genetic variationSystemic diseaseHallmarks of cancerTumor-related thrombosisGenetic variationGene-environment interactionsCancer-related deathsComplexity of cancerMolecular basisTreat human cancersNervous system interactionsMechanisms of carcinogenesisHuman cancersImprove patient qualityCancer cachexiaSystemic manifestationsTumor micro-Cancer outcomesDistant organsTumor initiationMolecular oncologyTumorPatients' qualityPrevent cancerCancerNeutrophils in Physiology and Pathology
Aroca-Crevillén A, Vicanolo T, Ovadia S, Hidalgo A. Neutrophils in Physiology and Pathology. Annual Review Of Pathology Mechanisms Of Disease 2024, 19: 227-259. PMID: 38265879, PMCID: PMC11060889, DOI: 10.1146/annurev-pathmechdis-051222-015009.Peer-Reviewed Original Research