Featured Publications
The circadian neutrophil, inside-out
Ovadia S, Özcan A, Hidalgo A. The circadian neutrophil, inside-out. Journal Of Leukocyte Biology 2023, 113: 555-566. PMID: 36999376, PMCID: PMC10583762, DOI: 10.1093/jleuko/qiad038.Peer-Reviewed Original Research
2020
Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation
Adrover JM, Aroca-Crevillén A, Crainiciuc G, Ostos F, Rojas-Vega Y, Rubio-Ponce A, Cilloniz C, Bonzón-Kulichenko E, Calvo E, Rico D, Moro MA, Weber C, Lizasoaín I, Torres A, Ruiz-Cabello J, Vázquez J, Hidalgo A. Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation. Nature Immunology 2020, 21: 135-144. PMID: 31932813, PMCID: PMC7223223, DOI: 10.1038/s41590-019-0571-2.Peer-Reviewed Original ResearchConceptsMagnitude of inflammationNeutrophil extracellular trapsNeutrophil proteomeGranule contentsInflammatory injuryRespiratory distressPneumonia patientsExtracellular trapsCell-intrinsic programsProgressive lossHuman neutrophilsNET formationProtein storesNeutrophilsInflammationLungAntimicrobial functionMouse mutantsCircadian cyclePatientsInjuryTime of dayArmamentariumIncidenceSeverity
2013
Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance
Casanova-Acebes M, Pitaval C, Weiss LA, Nombela-Arrieta C, Chèvre R, A-González N, Kunisaki Y, Zhang D, van Rooijen N, Silberstein LE, Weber C, Nagasawa T, Frenette PS, Castrillo A, Hidalgo A. Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance. Cell 2013, 153: 1025-1035. PMID: 23706740, PMCID: PMC4128329, DOI: 10.1016/j.cell.2013.04.040.Peer-Reviewed Original ResearchConceptsBone marrowFunction of neutrophilsNeutrophil clearanceHomeostatic clearanceHematopoietic nicheNeutrophil eliminationHomeostatic signalsAged neutrophilsNeutrophilsRhythmic modulationMarrowCircadian eventsNuclear receptorsHematopoietic progenitorsClearanceInflammationLeukocytesMiceMacrophagesCirculationReceptors