2020
Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study
Rogne T, Solligård E, Burgess S, Brumpton BM, Paulsen J, Prescott HC, Mohus RM, Gustad LT, Mehl A, Åsvold BO, DeWan AT, Damås JK. Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study. PLOS Medicine 2020, 17: e1003413. PMID: 33196656, PMCID: PMC7668585, DOI: 10.1371/journal.pmed.1003413.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexBloodstream infectionsBSI incidenceBSI mortalityHazard ratioMass indexGeneral populationPopulation-based cohortAnalysis of patientsTerms of mortalityMendelian randomization studyTraditional epidemiological studiesMendelian randomization analysisObesity paradoxMean ageObservational studyEpidemiological studiesRandomization studyCausal associationSepsisMortalityPatientsInfectionRandomization analysis
2002
A second kindred linked to DFNA20 (17q25.3) reduces the genetic interval
DeWan A, Parrado A, Leal S. A second kindred linked to DFNA20 (17q25.3) reduces the genetic interval. Clinical Genetics 2002, 63: 39-45. PMID: 12519370, PMCID: PMC6143177, DOI: 10.1034/j.1399-0004.2003.630106.x.Peer-Reviewed Original Research
2001
Linkage of Left Ventricular Contractility to Chromosome 11 in Humans
Arnett D, Devereux R, Kitzman D, Oberman A, Hopkins P, Atwood L, Dewan A, Rao DC. Linkage of Left Ventricular Contractility to Chromosome 11 in Humans. Hypertension 2001, 38: 767-772. PMID: 11641284, DOI: 10.1161/hy1001.092650.Peer-Reviewed Original ResearchMeSH KeywordsBlack PeopleChromosome MappingChromosomes, Human, Pair 11Chromosomes, Human, Pair 12Chromosomes, Human, Pair 22EchocardiographyFemaleGenetic LinkageGenome, HumanGenotypeHeart VentriclesHumansHypertensionLod ScoreMaleMicrosatellite RepeatsMiddle AgedMyocardial ContractionPhenotypeQuantitative Trait, HeritableWhite PeopleConceptsCongestive heart failureLV contractilityHeart failureVentricular contractilityMyocardial contractilityImpaired LV contractilityLeft ventricular contractilityAge 60 yearsHypertension Genetic Epidemiology NetworkGenetic Epidemiology NetworkBiethnic sampleCardiovascular deathContractile impairmentFamilial hypertrophic cardiomyopathyMean ageEchocardiographic measurementsHypertrophic cardiomyopathyHypertensive siblingsContractilityEpidemiology NetworkMajor causeSusceptibility genesAgeEthnic groupsSuggestive evidence
2000
A Genome Scan for Renal Function among Hypertensives: the HyperGEN Study
DeWan A, Arnett D, Atwood L, Province M, Lewis C, Hunt S, Eckfeldt J. A Genome Scan for Renal Function among Hypertensives: the HyperGEN Study. American Journal Of Human Genetics 2000, 68: 136-144. PMID: 11115379, PMCID: PMC1234906, DOI: 10.1086/316927.Peer-Reviewed Original ResearchMeSH KeywordsBlack or African AmericanBlack PeopleBody Mass IndexChromosomes, Human, Pair 1Chromosomes, Human, Pair 3Chromosomes, Human, Pair 6CreatineFemaleGenotypeHumansHypertensionKidneyKidney Function TestsLod ScoreMaleMiddle AgedModels, GeneticNuclear FamilyPhenotypeQuantitative Trait, HeritableSoftwareWhite PeopleConceptsCreatinine clearanceRenal functionAfrican American subjectsWhite subjectsHypertension Genetic Epidemiology Network (HyperGEN) studyLarge biracial sampleResidual creatinine clearanceComplications of hypertensionCreatinine clearance measurementsGood evidenceHypertensive individualsKidney functionMean ageAmerican subjectsBiracial sampleHypertensive siblingsApolipoprotein DHyperGEN studyClearanceClearance measurementsHypertensionCandidate genesSpecific genetic regionsUnderlying genetic componentSubjects