2023
Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study
Hosier H, Lipkind H, Rasheed H, DeWan A, Rogne T. Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study. Hypertension 2023, 80: 1067-1076. PMID: 36883459, DOI: 10.1161/hypertensionaha.122.20426.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaProtective effectCholesteryl Ester Transfer Protein InhibitionLack of effectMendelian randomization studyMendelian randomization analysisMaternal morbidityElevated HDLLeading causeLipid levelsObservational studyPreeclampsiaLipid measurementsReduced riskAncestry groupsPharmacological targetsRandomization studyHDLLDLRandomization analysisSingle nucleotide polymorphismsNew targetsDyslipidemiaRiskProtein inhibitionEarly-Onset Colorectal Cancer Somatic Gene Mutations by Population Subgroups.
Shen X, DeWan A, Johnson C. Early-Onset Colorectal Cancer Somatic Gene Mutations by Population Subgroups. Cancer Discovery 2023, 13: 530-531. PMID: 36855917, DOI: 10.1158/2159-8290.cd-22-1464.Peer-Reviewed Original Research
2022
Circulating miRNAs in the first trimester and pregnancy complications: a systematic review
Subramanian A, Weiss D, Nyhan K, Dewan A, Jukic A. Circulating miRNAs in the first trimester and pregnancy complications: a systematic review. Epigenetics 2022, 18: 2152615. PMID: 36503407, PMCID: PMC9980650, DOI: 10.1080/15592294.2022.2152615.Peer-Reviewed Original ResearchConceptsPregnancy complicationsSystematic reviewFirst trimesterMiR-520hPlacental originMiR-518bFuture pregnancy complicationsMost pregnancy complicationsFirst-trimester serumFirst trimester biomarkersPotential early biomarkersGestational hypertensionPreterm birthPlacental pathologyEarly biomarkersComplicationsEarly placentationPotential biomarkersPlasma miRNAsPreeclampsiaMiR-125bEarly detectionBiomarkersMiR-365aMost evidence
2020
Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study
Rogne T, Solligård E, Burgess S, Brumpton BM, Paulsen J, Prescott HC, Mohus RM, Gustad LT, Mehl A, Åsvold BO, DeWan AT, Damås JK. Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study. PLOS Medicine 2020, 17: e1003413. PMID: 33196656, PMCID: PMC7668585, DOI: 10.1371/journal.pmed.1003413.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexBloodstream infectionsBSI incidenceBSI mortalityHazard ratioMass indexGeneral populationPopulation-based cohortAnalysis of patientsTerms of mortalityMendelian randomization studyTraditional epidemiological studiesMendelian randomization analysisObesity paradoxMean ageObservational studyEpidemiological studiesRandomization studyCausal associationSepsisMortalityPatientsInfectionRandomization analysisDiscovery and Mediation Analysis of Cross-Phenotype Associations Between Asthma and Body Mass Index in 12q13.2
Salinas YD, Wang Z, DeWan AT. Discovery and Mediation Analysis of Cross-Phenotype Associations Between Asthma and Body Mass Index in 12q13.2. American Journal Of Epidemiology 2020, 190: 85-94. PMID: 32700739, PMCID: PMC7784522, DOI: 10.1093/aje/kwaa144.Peer-Reviewed Original ResearchConceptsBody mass indexMass indexComorbidity of asthmaWhite British subjectsCross-phenotype associationsAdult asthmaAsthma diagnosisAsthmaConfounder adjustmentAsthma associationsBMI associationsMediation analysisLimited evidenceCandidate gene studiesBMIObesityUK BiobankAssociationDiagnosisTwin studiesAgeFurther characterizationComorbiditiesConfounders
2018
GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21
Wiemels JL, Walsh KM, de Smith AJ, Metayer C, Gonseth S, Hansen HM, Francis SS, Ojha J, Smirnov I, Barcellos L, Xiao X, Morimoto L, McKean-Cowdin R, Wang R, Yu H, Hoh J, DeWan AT, Ma X. GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Nature Communications 2018, 9: 286. PMID: 29348612, PMCID: PMC5773513, DOI: 10.1038/s41467-017-02596-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCaliforniaChild, PreschoolChromosomes, Human, Pair 17Chromosomes, Human, Pair 8FemaleGene FrequencyGenetic Predisposition to DiseaseGenome-Wide Association StudyHispanic or LatinoHumansInfantInfant, NewbornMalePolymorphism, Single NucleotidePrecursor Cell Lymphoblastic Leukemia-LymphomaRisk FactorsConceptsNew risk lociRisk lociGenome-wide association studiesGrowth regulation pathwaysGenetic associationAcute lymphoblastic leukemiaNovel genetic associationsChildhood acute lymphoblastic leukemiaGenetic Epidemiology ResearchTranscription factorsStrong genetic associationGene expressionAssociation studiesLymphocyte developmentMYC oncogeneChromosome 17q12Oncology GroupLymphoblastic leukemiaLociChildren's Oncology GroupCalifornia Childhood Leukemia StudyChildhood Leukemia StudyStructural contactsYear of birthNon-Latino whites
2016
Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African Americans
Salinas YD, Wang L, DeWan AT. Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African Americans. BMC Genomic Data 2016, 17: 78. PMID: 27296613, PMCID: PMC4907283, DOI: 10.1186/s12863-016-0387-0.Peer-Reviewed Original ResearchConceptsBody mass indexWomen's Health InitiativeEthnic-specific associationsMass indexSingle nucleotide polymorphismsHealth initiativesAfrican AmericansGreater body mass indexLower body mass indexMulti-Ethnic StudyP-valueAfrican American subjectsAmerican subjectsSuggestive single-nucleotide polymorphismsEuropean-American subjectsGene-based therapiesMultiethnic populationSNP rs12255372Ethnic-specific effectsSignificant associationObesityMESA HispanicsRs12255372BackgroundGenome-wide association studiesConfidence intervals
2012
Whole-exome sequencing of a pedigree segregating asthma
DeWan AT, Egan KB, Hellenbrand K, Sorrentino K, Pizzoferrato N, Walsh KM, Bracken MB. Whole-exome sequencing of a pedigree segregating asthma. BMC Medical Genomics 2012, 13: 95. PMID: 23046476, PMCID: PMC3563469, DOI: 10.1186/1471-2350-13-95.Peer-Reviewed Original ResearchConceptsNon-asthmatic childrenWhole-exome sequencingAsthma candidate genesAsthmatic childrenAsthmaAsthma associationsAffected motherExome sequencingUnaffected fatherAsthma-susceptibility variantsPrediction scoreUnaffected offspringCommon risk variantsRisk variantsCandidate genesChildrenNonsynonymous variantsAffected offspring
2010
PDE11A associations with asthma: Results of a genome-wide association scan
DeWan AT, Triche EW, Xu X, Hsu LI, Zhao C, Belanger K, Hellenbrand K, Willis-Owen SA, Moffatt M, Cookson WO, Himes BE, Weiss ST, Gauderman WJ, Baurley JW, Gilliland F, Wilk JB, O’Connor G, Strachan DP, Hoh J, Bracken MB. PDE11A associations with asthma: Results of a genome-wide association scan. Journal Of Allergy And Clinical Immunology 2010, 126: 871-873.e9. PMID: 20920776, PMCID: PMC3133448, DOI: 10.1016/j.jaci.2010.06.051.Peer-Reviewed Original Research
2006
HTRA1 Promoter Polymorphism in Wet Age-Related Macular Degeneration
DeWan A, Liu M, Hartman S, Zhang SS, Liu DT, Zhao C, Tam PO, Chan WM, Lam DS, Snyder M, Barnstable C, Pang CP, Hoh J. HTRA1 Promoter Polymorphism in Wet Age-Related Macular Degeneration. Science 2006, 314: 989-992. PMID: 17053108, DOI: 10.1126/science.1133807.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingAsian PeopleChromatin ImmunoprecipitationChromosomes, Human, Pair 10FemaleGenetic Predisposition to DiseaseGenotypeHeLa CellsHigh-Temperature Requirement A Serine Peptidase 1HumansLinkage DisequilibriumMacular DegenerationMaleMiddle AgedPolymorphism, Single NucleotidePromoter Regions, GeneticRetinal NeovascularizationSerine EndopeptidasesSerum Response FactorTranscription Factor AP-2ConceptsAssociation mapping strategySerine protease genesSingle nucleotide polymorphismsHTRA1 promoter polymorphismPromoter regionProtease geneChromosome 10q26H geneRisk-associated genotypesGenesGenetic risk factorsMajor genetic risk factorWild-type genotypeFactor H genePolymorphismGenotypesMapping strategyComplement factor H (CFH) genePromoter polymorphismHtrA1Age-related macular degeneration
2002
A second kindred linked to DFNA20 (17q25.3) reduces the genetic interval
DeWan A, Parrado A, Leal S. A second kindred linked to DFNA20 (17q25.3) reduces the genetic interval. Clinical Genetics 2002, 63: 39-45. PMID: 12519370, PMCID: PMC6143177, DOI: 10.1034/j.1399-0004.2003.630106.x.Peer-Reviewed Original Research
2001
Linkage of Left Ventricular Contractility to Chromosome 11 in Humans
Arnett D, Devereux R, Kitzman D, Oberman A, Hopkins P, Atwood L, Dewan A, Rao DC. Linkage of Left Ventricular Contractility to Chromosome 11 in Humans. Hypertension 2001, 38: 767-772. PMID: 11641284, DOI: 10.1161/hy1001.092650.Peer-Reviewed Original ResearchMeSH KeywordsBlack PeopleChromosome MappingChromosomes, Human, Pair 11Chromosomes, Human, Pair 12Chromosomes, Human, Pair 22EchocardiographyFemaleGenetic LinkageGenome, HumanGenotypeHeart VentriclesHumansHypertensionLod ScoreMaleMicrosatellite RepeatsMiddle AgedMyocardial ContractionPhenotypeQuantitative Trait, HeritableWhite PeopleConceptsCongestive heart failureLV contractilityHeart failureVentricular contractilityMyocardial contractilityImpaired LV contractilityLeft ventricular contractilityAge 60 yearsHypertension Genetic Epidemiology NetworkGenetic Epidemiology NetworkBiethnic sampleCardiovascular deathContractile impairmentFamilial hypertrophic cardiomyopathyMean ageEchocardiographic measurementsHypertrophic cardiomyopathyHypertensive siblingsContractilityEpidemiology NetworkMajor causeSusceptibility genesAgeEthnic groupsSuggestive evidence
2000
A Genome Scan for Renal Function among Hypertensives: the HyperGEN Study
DeWan A, Arnett D, Atwood L, Province M, Lewis C, Hunt S, Eckfeldt J. A Genome Scan for Renal Function among Hypertensives: the HyperGEN Study. American Journal Of Human Genetics 2000, 68: 136-144. PMID: 11115379, PMCID: PMC1234906, DOI: 10.1086/316927.Peer-Reviewed Original ResearchMeSH KeywordsBlack or African AmericanBlack PeopleBody Mass IndexChromosomes, Human, Pair 1Chromosomes, Human, Pair 3Chromosomes, Human, Pair 6CreatineFemaleGenotypeHumansHypertensionKidneyKidney Function TestsLod ScoreMaleMiddle AgedModels, GeneticNuclear FamilyPhenotypeQuantitative Trait, HeritableSoftwareWhite PeopleConceptsCreatinine clearanceRenal functionAfrican American subjectsWhite subjectsHypertension Genetic Epidemiology Network (HyperGEN) studyLarge biracial sampleResidual creatinine clearanceComplications of hypertensionCreatinine clearance measurementsGood evidenceHypertensive individualsKidney functionMean ageAmerican subjectsBiracial sampleHypertensive siblingsApolipoprotein DHyperGEN studyClearanceClearance measurementsHypertensionCandidate genesSpecific genetic regionsUnderlying genetic componentSubjects