Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells
Choi J, Huebner AJ, Clement K, Walsh RM, Savol A, Lin K, Gu H, Di Stefano B, Brumbaugh J, Kim SY, Sharif J, Rose CM, Mohammad A, Odajima J, Charron J, Shioda T, Gnirke A, Gygi S, Koseki H, Sadreyev RI, Xiao A, Meissner A, Hochedlinger K. Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells. Nature 2017, 548: 219-223. PMID: 28746311, PMCID: PMC5905676, DOI: 10.1038/nature23274.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlastocystChromosomal InstabilityDNA MethylationEmbryonic Stem CellsFemaleGenomic ImprintingKaryotypingMaleMAP Kinase Kinase 1MAP Kinase Kinase 2Mice