2022
Prediction of Adverse Pathology at Radical Prostatectomy in Grade Group 2 and 3 Prostate Biopsies Using Machine Learning.
Paulson N, Zeevi T, Papademetris M, Leapman MS, Onofrey JA, Sprenkle PC, Humphrey PA, Staib LH, Levi AW. Prediction of Adverse Pathology at Radical Prostatectomy in Grade Group 2 and 3 Prostate Biopsies Using Machine Learning. JCO Clinical Cancer Informatics 2022, 6: e2200016. PMID: 36179281, DOI: 10.1200/cci.22.00016.Peer-Reviewed Original ResearchConceptsGrade group 2Prostate biopsyRadical prostatectomyAdverse outcomesGroup 2GG-2Core prostate biopsyProstate cancer outcomesPatient's clinical riskClinical risk assessmentCore needle biopsyOngoing clinical needAdverse outcome predictionRetrospective reviewAdverse pathologyCAPRA scoreEntire cohortCancer outcomesPathologic diagnosisNeedle biopsyClinical riskDisease outcomeProstate cancerBiopsyDisease one
2021
Doubling of Decipher Biopsy Genomic Score Is Related to Disease Reclassification on Subsequent Surveillance Biopsy but Not Adverse Features on Radical Prostatectomy
Ghabili K, Paulson N, Syed JS, Nawaf CB, Khajir G, Martin DT, Onofrey J, Leapman MS, Levi A, Weinreb JC, Humphrey PA, Sprenkle PC. Doubling of Decipher Biopsy Genomic Score Is Related to Disease Reclassification on Subsequent Surveillance Biopsy but Not Adverse Features on Radical Prostatectomy. Case Reports In Urology 2021, 2021: 2687416. PMID: 33936831, PMCID: PMC8054861, DOI: 10.1155/2021/2687416.Peer-Reviewed Original ResearchBiopsy scoreRadical prostatectomyActive surveillanceBiopsy Gleason grade groupGleason grade group 2Gleason grade group 4Low-risk prostate cancerActive surveillance populationGrade group 4Subsequent surveillance biopsiesOrgan-confined diseaseGrade group 2Gleason grade groupLow-risk categoryBiopsy reclassificationDisease reclassificationSurveillance biopsiesFinal pathologyThird biopsySecond biopsySurveillance populationProstate cancerAdverse featuresGroup 2Genomic score
2017
The positive predictive value of PI-RADS 4 lesions stratified by lesion number in biopsy naïve men.
Syed J, Javier-desloges J, Nguyen K, Sheridan A, Levi A, Weinreb J, Sprenkle P. The positive predictive value of PI-RADS 4 lesions stratified by lesion number in biopsy naïve men. Journal Of Clinical Oncology 2017, 35: 29-29. DOI: 10.1200/jco.2017.35.6_suppl.29.Peer-Reviewed Original ResearchPI-RADS 4 lesionsPositive predictive valueBiopsy-naïve menNaïve menPredictive valuePI-RADS 3PI-RADS version 2PI-RADS 4Cancer detection rateChi-square testPSA densityEntire cohortMean ageFusion biopsyProstate cancerSingle lesionLesion locationGroup 2Group 1Group 3LesionsAssessment scoresLesion numberCategorical variablesFurther assessment