2021
High-Risk Human Papillomavirus Testing, Genotyping, and Histopathologic Follow-up in Women With Abnormal Glandular Cells on Papanicolaou Tests
Zuo T, Levi AW, Lin Q, Abi-Raad R, Adeniran AJ, Cai G. High-Risk Human Papillomavirus Testing, Genotyping, and Histopathologic Follow-up in Women With Abnormal Glandular Cells on Papanicolaou Tests. American Journal Of Clinical Pathology 2021, 156: 569-576. PMID: 33728437, DOI: 10.1093/ajcp/aqaa265.Peer-Reviewed Original ResearchConceptsPositive hrHPV resultsCervical intraepithelial neoplasiaHrHPV resultsHrHPV testingCIN2-3Intraepithelial neoplasiaPapanicolaou testCervical carcinomaHigh risk human papillomavirus statusHigh-risk human papillomavirus (hrHPV) testingHigh-grade cervical intraepithelial neoplasiaLow-grade cervical intraepithelial neoplasiaHuman papillomavirus testingHuman papillomavirus (HPV) statusManagement of patientsAbnormal glandular cellsHPV genotypesHPV subtypesAGC casesPap testFollow-upHistologic followHigh lesionsType 16Reactive changes
2016
A Comparison of the Roche Cobas HPV Test With the Hybrid Capture 2 Test for the Detection of High-Risk Human Papillomavirus Genotypes
Levi AW, Bernstein JI, Hui P, Duch K, Schofield K, Chhieng DC. A Comparison of the Roche Cobas HPV Test With the Hybrid Capture 2 Test for the Detection of High-Risk Human Papillomavirus Genotypes. Archives Of Pathology & Laboratory Medicine 2016, 140: 153-7. PMID: 26910220, DOI: 10.5858/arpa.2015-0027-oa.Peer-Reviewed Original ResearchConceptsHigh-risk human papillomavirusHuman papillomavirus assaysCobas human papillomavirus (HPV) testHigh-risk human papillomavirus DNAHybrid Capture 2 testHuman papillomavirus testingHuman papillomavirus testHuman papillomavirus DNAHuman papillomavirusPapillomavirus DNAHigh-risk human papillomavirus genotypesRoche cobas HPV testRoche CobasSurePath preparationsThinPrep specimensDiscordant resultsHybrid captureCobas HPV TestHuman papillomavirus resultsLiquid-based cytology samplesHybrid Capture 2Human papillomavirus genotypesLiquid-based preparationsHPV testCapture 2
2014
Prior High-Risk Human Papillomavirus Testing and Papanicolaou Test Results of 70 Invasive Cervical Carcinomas Diagnosed in 2012: Results of a Retrospective Multicenter Study
Zhao C, Li Z, Nayar R, Levi AW, Winkler BA, Moriarty AT, Barkan GA, Rao J, Miller F, Fan F, Zhou Z, Si Q, Fischer AH, Sturgis CD, Jing X, Marshall CB, Witt BL, Birdsong GG, Crothers BA. Prior High-Risk Human Papillomavirus Testing and Papanicolaou Test Results of 70 Invasive Cervical Carcinomas Diagnosed in 2012: Results of a Retrospective Multicenter Study. Archives Of Pathology & Laboratory Medicine 2014, 139: 184-8. PMID: 24694342, DOI: 10.5858/arpa.2014-0028-oa.Peer-Reviewed Original ResearchConceptsInvasive cervical cancerInvasive cervical carcinomaHrHPV testingCervical cancerCervical carcinomaHPV testingHistologic diagnosisPersistent high-risk human papillomavirus (HPV) infectionHigh-risk human papillomavirus (hrHPV) testingHigh-risk human papillomavirus infectionHigh-risk HPV testingPrimary HPV testingHuman papillomavirus testingHuman papillomavirus infectionRetrospective multicenter studyCervical epithelial lesionsCurrent screening guidelinesSquamous cell carcinomaHPV ratesPapillomavirus infectionMulticenter studyScreening guidelinesCell carcinomaPapanicolaou testSingle institution
2012
Increasing Cytotechnologist Workload Above 100 Slides per Day Using the BD FocalPoint GS Imaging System Negatively Affects Screening Performance
Levi AW, Galullo P, Gordy K, Mikolaiski N, Schofield K, Elsheikh TM, Harigopal M, Chhieng DC. Increasing Cytotechnologist Workload Above 100 Slides per Day Using the BD FocalPoint GS Imaging System Negatively Affects Screening Performance. American Journal Of Clinical Pathology 2012, 138: 811-815. PMID: 23161714, DOI: 10.1309/ajcptydd9g2ncumf.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Squamous CellCytodiagnosisDiagnostic ImagingFalse Negative ReactionsFemaleHumansImage Processing, Computer-AssistedMass ScreeningMedical Laboratory PersonnelQuality ControlSensitivity and SpecificityTime FactorsUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsWorkloadComparing Two Methods of Detection for Chlamydia trachomatis in Liquid-Based Papanicolaou Tests
Levi AW, Beckman D, Hui P, Schofield K, Harigopal M, Chhieng DC. Comparing Two Methods of Detection for Chlamydia trachomatis in Liquid-Based Papanicolaou Tests. American Journal Of Clinical Pathology 2012, 138: 236-240. PMID: 22904135, DOI: 10.1309/ajcp2b7xqtcnamjp.Peer-Reviewed Original ResearchConceptsHC2 assayBD Viper SystemXTR TechnologyPositive predictive valueDNA assaysLiquid-based Papanicolaou testsNucleic acidsC trachomatisChlamydia trachomatisPredictive valueHybrid Capture 2Reverse transcriptase-polymerase chain reactionChlamydia trachomatis testingTranscriptase-polymerase chain reactionViper SystemComparable specificityCapture 2Papanicolaou testChlamydial infectionCytology samplesMethod of detectionThinPrep specimensTrachomatisAssaysSensitivity rateThe Positive Impact of Simultaneous Implementation of the BD FocalPoint GS Imaging System and Lean Principles on the Operation of Gynecologic Cytology
Wong R, Levi AW, Harigopal M, Schofield K, Chhieng DC. The Positive Impact of Simultaneous Implementation of the BD FocalPoint GS Imaging System and Lean Principles on the Operation of Gynecologic Cytology. Archives Of Pathology & Laboratory Medicine 2012, 136: 183-9. PMID: 22288966, DOI: 10.5858/arpa.2011-0139-oa.Peer-Reviewed Original Research
2011
Implementation of FocalPoint GS location‐guided imaging system
Levi AW, Chhieng DC, Schofield K, Kowalski D, Harigopal M. Implementation of FocalPoint GS location‐guided imaging system. Cancer Cytopathology 2011, 120: 126-133. PMID: 22505211, DOI: 10.1002/cncy.20187.Peer-Reviewed Original ResearchConceptsASC-US casesHR-HPV positive rateLow-risk patient populationHigh-risk human papillomavirusASC-US interpretationsRoutine clinical settingPromising screening toolPap testHuman papillomavirusPapanicolaou testPatient populationBacterial vaginosisDrug AdministrationSIL ratioClinical settingScreening toolDiagnostic categoriesLaboratory information systemGynecologic cytologyPrimary screeningSignificant increaseFalse negative fractionPositive rateHigh percentageCurrent studyUse of high‐risk human papillomavirus testing in patients with low‐grade squamous intraepithelial lesions
Levi AW, Harigopal M, Hui P, Schofield K, Chhieng DC. Use of high‐risk human papillomavirus testing in patients with low‐grade squamous intraepithelial lesions. Cancer Cytopathology 2011, 119: 228-234. PMID: 21732551, DOI: 10.1002/cncy.20172.Peer-Reviewed Original ResearchConceptsLow-grade squamous intraepithelial lesionsHR-HPV testingHPV testingCIN 2Colposcopy rateHR-HPVRelative light units/cutoffCervical intraepithelial neoplasia 2High-risk human papillomavirusHR-HPV statusRLU/COIntraepithelial neoplasia 2Hybrid Capture 2Squamous intraepithelial lesionsCIN 1 lesionsLarge teaching hospitalNegative predictive valueLSIL cytologyHPV statusIntraepithelial lesionsCapture 2Human papillomavirusTeaching hospitalCytologic diagnosisSevere lesionsComparison of Affirm VPIII and Papanicolaou Tests in the Detection of Infectious Vaginitis
Levi AW, Harigopal M, Hui P, Schofield K, Chhieng DC. Comparison of Affirm VPIII and Papanicolaou Tests in the Detection of Infectious Vaginitis. American Journal Of Clinical Pathology 2011, 135: 442-447. PMID: 21350100, DOI: 10.1309/ajcp7tbn5vzuglzu.Peer-Reviewed Original ResearchConceptsAffirm VPIIIPap testPapanicolaou testRoutine Pap testRoutine Papanicolaou testCandida speciesSensitive diagnostic testInfectious vaginitisLarge academic institutionPatient populationTrichomonas infectionBacterial vaginosisCandida vaginitisG vaginalisT vaginalisStudy populationHigh incidenceDiagnostic testsMolecular testsPatientsVaginitisVaginalisMorphologic identificationVaginosisCandidiasis
2003
Atypical squamous cells of undetermined significance in liquid‐based cytologic specimens
Levi AW, Kelly DP, Rosenthal DL, Ronnett BM. Atypical squamous cells of undetermined significance in liquid‐based cytologic specimens. Cancer 2003, 99: 191-197. PMID: 12925979, DOI: 10.1002/cncr.11507.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overColposcopyCost-Benefit AnalysisDNA, ViralFemaleFollow-Up StudiesHumansMiddle AgedModels, StatisticalPapanicolaou TestPapillomaviridaePapillomavirus InfectionsPatient Care PlanningPolymerase Chain ReactionPractice Guidelines as TopicSensitivity and SpecificityTumor Virus InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsConceptsLow-grade squamous intraepithelial lesionsSquamous intraepithelial lesionsHigh-grade squamous intraepithelial lesionsAtypical squamous cellsHPV test resultsHigh-grade lesionsASCUS smearsHPV-positive smearsIntraepithelial lesionsSquamous cellsUndetermined significanceHuman papillomavirus (HPV) DNA testingASCUS interpretationHigh-risk HPV typesHPV-positive casesHPV DNA testingHigh-risk typesLiquid-based Pap smearsLow-grade lesionsDNA testingColposcopy triageHPV testingASCUS cytologyHPV typesPap smear