2021
An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy
Perincheri S, Levi AW, Celli R, Gershkovich P, Rimm D, Morrow JS, Rothrock B, Raciti P, Klimstra D, Sinard J. An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy. Modern Pathology 2021, 34: 1588-1595. PMID: 33782551, PMCID: PMC8295034, DOI: 10.1038/s41379-021-00794-x.Peer-Reviewed Original ResearchConceptsMemorial Sloan-Kettering Cancer CenterCore biopsyPredictive valueDiagnostic accuracyProstate core needle biopsiesCore needle biopsySurgical pathology practiceNegative predictive valueProstate core biopsiesPositive predictive valueProstate cancer detectionStrong diagnostic accuracyPoor quality scansCancer detectionCancer CenterProstate biopsyLeading causeNeedle biopsyTransrectal approachProstate cancerProstatic adenocarcinomaProstate carcinomaBiopsyPathology practiceProstate
2015
Detection and Genotype of High-Risk Human Papillomavirus in Fine-Needle Aspirates of Patients With Metastatic Squamous Cell Carcinoma Is Helpful in Determining Tumor Origin
Baldassarri R, Aronberg R, Levi AW, Yarbrough WG, Kowalski D, Chhieng D. Detection and Genotype of High-Risk Human Papillomavirus in Fine-Needle Aspirates of Patients With Metastatic Squamous Cell Carcinoma Is Helpful in Determining Tumor Origin. American Journal Of Clinical Pathology 2015, 143: 694-700. PMID: 25873503, DOI: 10.1309/ajcpcza4pszcfhq4.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaCobas 4800 systemRoche cobas 4800 systemMetastatic squamous cell carcinomaFine needle aspiratesHuman papillomavirusHR-HPVCell carcinomaHPV 16High-risk (HR) HPVSquamous cell carcinoma originatingHigh-risk human papillomavirusNeck squamous cell carcinomaHPV 16/18 genotypesHR-HPV testingHR-HPV detectionHR-HPV resultsCorresponding histologic specimensLeft parapharyngeal massElectronic health recordsCarcinoma originatingMediastinal lymphadenopathyNegative HNSCCProspective studyHistologic material
2014
Prior High-Risk Human Papillomavirus Testing and Papanicolaou Test Results of 70 Invasive Cervical Carcinomas Diagnosed in 2012: Results of a Retrospective Multicenter Study
Zhao C, Li Z, Nayar R, Levi AW, Winkler BA, Moriarty AT, Barkan GA, Rao J, Miller F, Fan F, Zhou Z, Si Q, Fischer AH, Sturgis CD, Jing X, Marshall CB, Witt BL, Birdsong GG, Crothers BA. Prior High-Risk Human Papillomavirus Testing and Papanicolaou Test Results of 70 Invasive Cervical Carcinomas Diagnosed in 2012: Results of a Retrospective Multicenter Study. Archives Of Pathology & Laboratory Medicine 2014, 139: 184-8. PMID: 24694342, DOI: 10.5858/arpa.2014-0028-oa.Peer-Reviewed Original ResearchConceptsInvasive cervical cancerInvasive cervical carcinomaHrHPV testingCervical cancerCervical carcinomaHPV testingHistologic diagnosisPersistent high-risk human papillomavirus (HPV) infectionHigh-risk human papillomavirus (hrHPV) testingHigh-risk human papillomavirus infectionHigh-risk HPV testingPrimary HPV testingHuman papillomavirus testingHuman papillomavirus infectionRetrospective multicenter studyCervical epithelial lesionsCurrent screening guidelinesSquamous cell carcinomaHPV ratesPapillomavirus infectionMulticenter studyScreening guidelinesCell carcinomaPapanicolaou testSingle institution
2003
Atypical squamous cells of undetermined significance in liquid‐based cytologic specimens
Levi AW, Kelly DP, Rosenthal DL, Ronnett BM. Atypical squamous cells of undetermined significance in liquid‐based cytologic specimens. Cancer 2003, 99: 191-197. PMID: 12925979, DOI: 10.1002/cncr.11507.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overColposcopyCost-Benefit AnalysisDNA, ViralFemaleFollow-Up StudiesHumansMiddle AgedModels, StatisticalPapanicolaou TestPapillomaviridaePapillomavirus InfectionsPatient Care PlanningPolymerase Chain ReactionPractice Guidelines as TopicSensitivity and SpecificityTumor Virus InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsConceptsLow-grade squamous intraepithelial lesionsSquamous intraepithelial lesionsHigh-grade squamous intraepithelial lesionsAtypical squamous cellsHPV test resultsHigh-grade lesionsASCUS smearsHPV-positive smearsIntraepithelial lesionsSquamous cellsUndetermined significanceHuman papillomavirus (HPV) DNA testingASCUS interpretationHigh-risk HPV typesHPV-positive casesHPV DNA testingHigh-risk typesLiquid-based Pap smearsLow-grade lesionsDNA testingColposcopy triageHPV testingASCUS cytologyHPV typesPap smear
2001
The pigmented “black” neuroendocrine tumor of the pancreas
Sehdev A, Levi A, Nadasdy T, Campbell K, Fishman E, Hruban R. The pigmented “black” neuroendocrine tumor of the pancreas. Cancer 2001, 92: 1984-1991. PMID: 11745274, DOI: 10.1002/1097-0142(20011001)92:7<1984::aid-cncr1718>3.0.co;2-0.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overHumansImmunohistochemistryMaleNeuroendocrine TumorsPancreatic NeoplasmsPigmentationConceptsMetastatic melanomaNeuroendocrine tumorsNeoplastic cellsIron stainIslet cell tumorsFontana-Masson stainPerineural invasionSecond patientHMB-45Large neoplasmsAdrenal glandCell tumorsIncidental findingBlack adenomaImmunohistochemical stainsPancreatic neoplasmsComputerized tomographySmall lipid inclusionsNeoplasmsTumorsPatientsUltrastructural examinationNeurosecretory granulesPancreasFontana-MassonCLINICAL SIGNIFICANCE OF DENUDED UROTHELIUM IN BLADDER BIOPSY
LEVI A, POTTER S, SCHOENBERG M, EPSTEIN J. CLINICAL SIGNIFICANCE OF DENUDED UROTHELIUM IN BLADDER BIOPSY. Journal Of Urology 2001, 166: 457-460. PMID: 11458047, DOI: 10.1016/s0022-5347(05)65963-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiopsyCarcinoma in SituFemaleHumansMaleMiddle AgedUrinary BladderUrinary Bladder NeoplasmsUrotheliumConceptsCold cup biopsyHistory of carcinomaCup biopsyBladder biopsiesSubsequent carcinomaPertinent clinical featuresTissue fragmentsLow-grade papillary tumorsSpecific pathological featuresDiagnosis of carcinomaBenign urothelial cellsCystoscopic impressionPatients 22Intravesical chemotherapyClinical featuresBladder lesionsBladder neoplasmsPredictive factorsLoop biopsyPapillary tumorsPathological featuresTissue inflammationBladder carcinomaEpithelial denudationMiscellaneous conditions
2000
Pseudohyperplastic Prostatic Adenocarcinoma on Needle Biopsy and Simple Prostatectomy
Levi A, Epstein J. Pseudohyperplastic Prostatic Adenocarcinoma on Needle Biopsy and Simple Prostatectomy. The American Journal Of Surgical Pathology 2000, 24: 1039-1046. PMID: 10935644, DOI: 10.1097/00000478-200008000-00001.Peer-Reviewed Original ResearchConceptsNeedle biopsyProstatic adenocarcinomaSimple prostatectomyMalignant diagnosisHigh molecular weight keratinSurgical pathology filesBenign hyperplastic glandsJohns Hopkins HospitalDiagnosis of cancerPathology filesTransurethral resectionPapillary infoldingsHyperplastic glandsAtypical glandsImmunohistochemical stainsConsult casesWeight keratinBiopsyCorpora amylaceaFrequent nucleoliHistologic attributesAdenocarcinomaBenign featuresCancerNuclear enlargement