Heparin-binding secretory transforming gene (hst) facilitates rat lactotrope cell tumorigenesis and induces prolactin gene transcription.
Shimon I, Hüttner A, Said J, Spirina O, Melmed S. Heparin-binding secretory transforming gene (hst) facilitates rat lactotrope cell tumorigenesis and induces prolactin gene transcription. Journal Of Clinical Investigation 1996, 97: 187-195. PMID: 8550832, PMCID: PMC507078, DOI: 10.1172/jci118388.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DivisionFemaleFibroblast Growth Factor 4Fibroblast Growth FactorsGene Expression Regulation, NeoplasticHumansNeoplasm InvasivenessPituitary NeoplasmsProlactinProlactinomaProliferating Cell Nuclear AntigenProto-Oncogene ProteinsProto-OncogenesRatsRats, WistarRecombinant ProteinsRNA, MessengerTranscription, GeneticTumor Cells, CulturedConceptsFibroblast growth factor 4Cell nuclear antigen stainingBasal PRL secretionGrowth hormone releaseDose-dependent increaseRecombinant FGF-4PRL secretionTumor cell culturesProlactin secretionSubcutaneous injectionAutocrine actionHormone releasePituitary cell lineAntigen stainingHuman prolactinomasProlactinoma developmentGH4 cellsHistologic invasivenessTumor growthCell tumorigenesisMRNA expressionPRL synthesisLuciferase reporterPrimary ratPituitary tumorigenesis