2020
Associations of meningioma molecular subgroup and tumor recurrence
Youngblood MW, Miyagishima DF, Jin L, Gupte T, Li C, Duran D, Montejo JD, Zhao A, Sheth A, Tyrtova E, Özduman K, Iacoangeli F, Peyre M, Boetto J, Pease M, Avşar T, Huttner A, Bilguvar K, Kilic T, Pamir MN, Amankulor N, Kalamarides M, Erson-Omay EZ, Günel M, Moliterno J. Associations of meningioma molecular subgroup and tumor recurrence. Neuro-Oncology 2020, 23: 783-794. PMID: 33068421, PMCID: PMC8099468, DOI: 10.1093/neuonc/noaa226.Peer-Reviewed Original ResearchConceptsDivergent clinical coursesMolecular subgroupsClinical courseClinical outcomesProgression-free survivalExtent of resectionKaplan-Meier analysisLong-term outcomesLow-grade tumorsCox proportional hazardsDistinct clinical outcomesPostoperative radiationIndependent predictorsMale sexRecurrence rateSurveillance imagingTumor recurrencePrevious recurrencesClinical prognosticationKi-67Outcome dataAggressive subgroupRecurrenceElevated recurrenceProportional hazards
2013
The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells
Fang L, Lowther DE, Meizlish ML, Anderson RC, Bruce JN, Devine L, Huttner AJ, Kleinstein SH, Lee JY, Stern JN, Yaari G, Lovato L, Cronk KM, O'Connor KC. The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells. Neuro-Oncology 2013, 15: 1479-1490. PMID: 23978377, PMCID: PMC3813416, DOI: 10.1093/neuonc/not110.Peer-Reviewed Original ResearchConceptsTumor-infiltrating B cellsImmune cell infiltratesT cell repertoireCell infiltrateB cellsT cellsCell repertoireAntigen experienceImmune checkpoint molecules PD-1Memory/effector T cellsCheckpoint molecules PD-1Antigen-driven B cell responsesEffector T cell populationsTumor microenvironmentT-cell infiltratesRegulatory T cellsEffector T cellsT-cell phenotypeT cell populationsB cell responsesPeripheral blood lymphocytesAntigen-experienced CD4Cell populationsB cell populationsB cell repertoire
2012
A 77‐year‐old man with sudden onset of left hand weakness and hematuria
Nagarajan P, Huttner A. A 77‐year‐old man with sudden onset of left hand weakness and hematuria. Neuropathology 2012, 33: 102-107. PMID: 22672570, DOI: 10.1111/j.1440-1789.2012.01328.x.Peer-Reviewed Original Research
2011
Unilateral Tongue Atrophy and Fasciculation
Blondin NA, Huttner A, Baehring JM. Unilateral Tongue Atrophy and Fasciculation. JAMA Neurology 2011, 68: 1478-1478. PMID: 22084136, DOI: 10.1001/archneurol.2011.652.Peer-Reviewed Original Research
1996
Relationship between camp induced inhibition of human meningioma cell proliferation and autocrine secretion of interleukin-6
Hüttner A, Lei T, Fahlbusch R, Schrell U, Adams E. Relationship between camp induced inhibition of human meningioma cell proliferation and autocrine secretion of interleukin-6. Life Sciences 1996, 58: 1323-1329. PMID: 8614289, DOI: 10.1016/0024-3205(96)00098-7.Peer-Reviewed Original ResearchConceptsInterleukin-6Intracellular cAMP levelsMeningioma proliferationCAMP levelsHuman meningioma cell proliferationAdenylyl cyclase-cAMP systemCultured meningioma cellsElevated intracellular cAMP levelsIL6 secretionMeningioma cell culturesInhibitory factorCholera toxinMeningioma cellsInhibitory effectAutocrine secretionMeningioma cell proliferationCell proliferationSecretionPotential rolePolyclonal antibodiesProliferationSimilar effectsCell culturesInhibitionPrevious studies