2019
Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis
Wingrove E, Liu ZZ, Patel KD, Arnal-Estapé A, Cai WL, Melnick MA, Politi K, Monteiro C, Zhu L, Valiente M, Kluger HM, Chiang VL, Nguyen DX. Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis. Cell Reports 2019, 27: 1277-1292.e7. PMID: 31018140, PMCID: PMC6592283, DOI: 10.1016/j.celrep.2019.03.085.Peer-Reviewed Original ResearchConceptsBrain metastasesBrain tumor microenvironmentLineage programTumor microenvironmentTumor plasticityStromal gene expressionTranscriptomic hallmarksGene expressionTranscriptional hallmarksMultiple tumor typesMolecular landscapeStromal interactionsMajor siteIntact tissueNeuroinflammatory responseSyngeneic modelPatient biopsiesTumor typesMetastasisMalignant cellsDifferent subtypesTumor cellsHallmarkTranscriptomeCells
2011
Tumor-stroma interactions a trademark for metastasis
Morales M, Planet E, Arnal-Estape A, Pavlovic M, Tarragona M, Gomis R. Tumor-stroma interactions a trademark for metastasis. The Breast 2011, 20: s50-s55. PMID: 22015293, DOI: 10.1016/s0960-9776(11)70294-6.Peer-Reviewed Original ResearchConceptsGenes associated with metastasisTumor-stroma interactionsPrimary tumorRisk of relapseTumor-stroma communicationAssociated with metastasisDisseminated diseaseMetastatic nestsMetastatic developmentImmune infiltrationBone colonizationClinical correlatesSystemic instigationMetastasisTumorCytokine-cytokine receptor interactionReceptor interactionCytokine-cytokine receptor interaction pathwayExpression profiling dataGenesRelapseLungPathway