2022
The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands
Wang W, Pyle AM. The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Molecular Cell 2022, 82: 4131-4144.e6. PMID: 36272408, PMCID: PMC9707737, DOI: 10.1016/j.molcel.2022.09.029.Peer-Reviewed Original ResearchMeSH KeywordsCarrier ProteinsDEAD Box Protein 58DEAD-box RNA HelicasesImmunity, InnateLigandsRNA, Double-StrandedRNA, ViralConceptsRNA moleculesRNA ligandsHigh-resolution cryo-EM structuresCryo-EM structureDouble-stranded RNARIG-I receptorInduction of autoimmunityViral RNA moleculesAutoinhibited conformationInnate immune receptorsHost RNARelated RNAProtein foldsMolecular basisUnique molecular featuresHigh-affinity conformationAntiviral sensingHost cellsRNA virusesRNA releaseImmune receptorsRNAViral RNAExquisite selectivityMolecular features
2014
The Linker Region of NS3 Plays a Critical Role in the Replication and Infectivity of Hepatitis C Virus
Kohlway A, Pirakitikulr N, Ding SC, Yang F, Luo D, Lindenbach BD, Pyle AM. The Linker Region of NS3 Plays a Critical Role in the Replication and Infectivity of Hepatitis C Virus. Journal Of Virology 2014, 88: 10970-10974. PMID: 24965468, PMCID: PMC4178846, DOI: 10.1128/jvi.00745-14.Peer-Reviewed Original Research