2019
Regulation of MT dynamics via direct binding of an Abl family kinase
Hu Y, Lyu W, Lowery LA, Koleske AJ. Regulation of MT dynamics via direct binding of an Abl family kinase. Journal Of Cell Biology 2019, 218: 3986-3997. PMID: 31699690, PMCID: PMC6891085, DOI: 10.1083/jcb.201812144.Peer-Reviewed Original ResearchConceptsAbl family kinasesC-terminal halfFamily kinasesMT dynamicsMT growthTubulin C-terminal tailsC-terminal tailStable reexpressionEssential regulatorCell shapeBinds microtubulesMT polymerizationAbl kinaseGenetic studiesDirect bindingFunctional interactionKinaseMicrotubulesABL2ReexpressionMT behaviorBindingRegulatorProteinGrowth
2018
A Role for the Non-Receptor Tyrosine Kinase Abl2/Arg in Experimental Neuroinflammation
Jacobsen FA, Scherer AN, Mouritsen J, Bragadóttir H, Thomas Bäckström B, Sardar S, Holmberg D, Koleske AJ, Andersson Å. A Role for the Non-Receptor Tyrosine Kinase Abl2/Arg in Experimental Neuroinflammation. Journal Of Neuroimmune Pharmacology 2018, 13: 265-276. PMID: 29550892, PMCID: PMC5928183, DOI: 10.1007/s11481-018-9783-8.Peer-Reviewed Original ResearchConceptsMultiple sclerosisExperimental autoimmune encephalomyelitis (EAE) modelT cell receptorCongenic mouse strainsExperimental neuroinflammationInflammation pathogenesisMyelin antigensEAE developmentExperimental arthritisAutoimmune responseImmune cellsDisease susceptibility factorsCongenic miceLymphocyte activationPharmacological inhibitionAbl kinaseSclerosisSusceptibility factorsMouse strainsDegenerative diseasesPotential drug targetsMouse genetic locusSingle nucleotide polymorphismsDisease etiologyAmino acid changesAnalysis of Cellular Tyrosine Phosphorylation via Chemical Rescue of Conditionally Active Abl Kinase
Wang Z, Kim MS, Martinez-Ferrando I, Koleske A, Pandey A, Cole P. Analysis of Cellular Tyrosine Phosphorylation via Chemical Rescue of Conditionally Active Abl Kinase. Biochemistry 2018, 57: 1390-1398. PMID: 29341593, PMCID: PMC5906802, DOI: 10.1021/acs.biochem.7b01158.Peer-Reviewed Original ResearchConceptsProtein kinaseNonreceptor tyrosine kinases AblMass spectrometry-based quantitative proteomicsNovel putative substratesTyrosine kinase AblCellular tyrosine phosphorylationExtracellular growth factorsChemical rescue approachIntracellular signal transductionQuantitative phosphoproteomicsUnanticipated functionCellular physiologyGrowth factorPhosphorylation sitesPutative substratesDirect substrateDownstream substratesSignal transductionReceptor kinaseQuantitative proteomicsTyrosine phosphorylationActive Abl kinasesAbl kinaseChemical rescueKinase
2016
Arg Deficiency Does not Influence the Course of Myelin Oligodendrocyte Glycoprotein (MOG35-55)-induced Experimental Autoimmune Encephalomyelitis
Jacobsen FA, Hulst C, Bäckström T, Koleske AJ, Andersson Å. Arg Deficiency Does not Influence the Course of Myelin Oligodendrocyte Glycoprotein (MOG35-55)-induced Experimental Autoimmune Encephalomyelitis. Journal Of Clinical & Cellular Immunology 2016, 2016: 420. PMID: 34527426, PMCID: PMC8439389, DOI: 10.4172/2155-9899.1000420.Peer-Reviewed Original ResearchExperimental autoimmune encephalomyelitisAutoimmune encephalomyelitisMyelin oligodendrocyte glycoproteinOligodendrocyte glycoproteinB cellsDevelopment of MOGB-cell traffickingDisease developmentSplenic B cellsLymphocyte phenotypesAbl kinaseImmune activationMultiple sclerosisImmunized miceRodent modelsEncephalomyelitisC57BL/6 backgroundStimulation assaysMiceArg kinaseNovel roleTyrosine kinaseMOGArg tyrosine kinasesActivation
2015
Structure of the ABL2/ARG kinase in complex with dasatinib
Ha BH, Simpson MA, Koleske AJ, Boggon TJ. Structure of the ABL2/ARG kinase in complex with dasatinib. Acta Crystallographica Section F: Structural Biology Communications 2015, 71: 443-448. PMID: 25849507, PMCID: PMC4388181, DOI: 10.1107/s2053230x15004793.Peer-Reviewed Original ResearchConceptsT-cell acute lymphoblastic leukemiaActivation loop tyrosinesABL kinase activationGlycine-rich P-loopCell morphogenesisCo-crystal structureBreakpoint cluster regionCellular functionsArg genesCatalytic domainAbl familyArg kinaseP-loopKinase activationBiological roleOpen conformationTyrosine kinaseAbl kinaseKinaseGenesKinase inhibitorsABL1 geneArgCluster regionTyrosine kinase inhibitors
2013
WAVE2 Regulates Epithelial Morphology and Cadherin Isoform Switching through Regulation of Twist and Abl
Bryce NS, Reynolds AB, Koleske AJ, Weaver AM. WAVE2 Regulates Epithelial Morphology and Cadherin Isoform Switching through Regulation of Twist and Abl. PLOS ONE 2013, 8: e64533. PMID: 23691243, PMCID: PMC3654908, DOI: 10.1371/journal.pone.0064533.Peer-Reviewed Original ResearchConceptsEpithelial morphogenesisAbl kinaseActin cytoskeletal rearrangementCell-cell junctionsE-cadherinRegulation of TwistTotal cell lysatesAbl kinase activityEpithelial morphologyTranscription factor Twist1N-cadherin proteinTwist1 expressionWAVE2 complexABL substratesCellular signalingInhibition of AblCadherin isoformsCytoskeletal rearrangementsTyrosine phosphorylationEpithelial-mesenchymal transitionKinase activityMorphological phenotypesFilament localizationCadherin expressionWAVE2