2017
Corticosteroid-induced dendrite loss and behavioral deficiencies can be blocked by activation of Abl2/Arg kinase
Shapiro LP, Omar MH, Koleske AJ, Gourley SL. Corticosteroid-induced dendrite loss and behavioral deficiencies can be blocked by activation of Abl2/Arg kinase. Molecular And Cellular Neuroscience 2017, 85: 226-234. PMID: 29107098, PMCID: PMC5767942, DOI: 10.1016/j.mcn.2017.10.007.Peer-Reviewed Original ResearchConceptsCorticosterone exposureHippocampal CA1 pyramidal neuronsStressor exposureArbor structureCA1 pyramidal neuronsAnhedonic-like behaviorClassical neurotransmitter systemsSpecific brain regionsMental health concernsDendrite lossPyramidal neuronsStress-related illnessesArg nonreceptor tyrosine kinaseNeuronal remodelingNeurotransmitter systemsNeural degenerationBehavioral abnormalitiesTrigger pointsCognitive declineBrain regionsKey next stepHealth concernKey mediatorMental healthPharmacological compoundsBrain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity
Miller MB, Yan Y, Machida K, Kiraly DD, Levy AD, Wu YI, Lam TT, Abbott T, Koleske AJ, Eipper BA, Mains RE. Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity. ACS Chemical Neuroscience 2017, 8: 1554-1569. PMID: 28418645, PMCID: PMC5517348, DOI: 10.1021/acschemneuro.7b00076.Peer-Reviewed Original ResearchConceptsLong-term potentiationCalpain sensitivityEffects of cocaineRat nucleus accumbensAdult rat nucleus accumbensRho GDP/GTP exchange factorRegion-specific effectsChronic cocaineNucleus accumbensSynaptic functionBrain regionsKALRN geneSpine morphologyPrefrontal cortexKal7CocainePotentiationFunctional significanceCalpainPhosphorylation
2013
Corticosteroid-Induced Neural Remodeling Predicts Behavioral Vulnerability and Resilience
Gourley SL, Swanson AM, Koleske AJ. Corticosteroid-Induced Neural Remodeling Predicts Behavioral Vulnerability and Resilience. Journal Of Neuroscience 2013, 33: 3107-3112. PMID: 23407965, PMCID: PMC3711631, DOI: 10.1523/jneurosci.2138-12.2013.Peer-Reviewed Original ResearchConceptsStressor exposureDendritic spinesDendritic spine densityRecovery periodCA1 pyramidal neuronsHippocampal CA1 neuronsCertain neuron populationsStress hormone exposureStress-related modificationsDistinct brain regionsBehavioral vulnerabilityDendritic retractionPyramidal neuronsCA1 neuronsNeural remodelingSpine densityStress-related diseasesHippocampal CA1Orbital cortexBasal amygdalaDendritic arborsHormone exposureNeuron populationsBrain regionsBrain circuits
2011
Cell adhesion signaling pathways: First responders to cocaine exposure?
Gourley SL, Taylor JR, Koleske AJ. Cell adhesion signaling pathways: First responders to cocaine exposure? Communicative & Integrative Biology 2011, 4: 30-3. PMID: 21509173, PMCID: PMC3073265, DOI: 10.4161/cib.4.1.14083.Peer-Reviewed Original ResearchCocaine exposureDendritic spinesDendritic spine structureChronic drug exposureCertain brain regionsExpression/functionDrug exposurePsychomotor sensitizationPsychostimulant exposureBrain regionsFirst respondersNeuronal shapeSpine structureHuman brainRespondersExposureSpineTyrosine kinaseRecent findingsNonreceptor tyrosine kinaseCell adhesion receptorsAdhesion receptorsDevelopmental periodAdhesion factorsCell adhesion factorsCell adhesion signaling pathways
Gourley S, Taylor J, Koleske A. Cell adhesion signaling pathways. Communicative & Integrative Biology 2011, 4: 30-33. DOI: 10.4161/cib.14083.Peer-Reviewed Original ResearchDendritic spinesDendritic spine structureChronic drug exposureCertain brain regionsExpression/functionDrug exposureCocaine exposurePsychomotor sensitizationPsychostimulant exposureBrain regionsNeuronal shapeSpine structureHuman brainExposureSpineTyrosine kinaseRecent findingsNonreceptor tyrosine kinaseCell adhesion receptorsAdhesion receptorsDevelopmental periodAdhesion factorsCell adhesion factorsFirst respondersCytoskeletal effectors