2014
Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors
DePoy LM, Perszyk RE, Zimmermann KS, Koleske AJ, Gourley SL. Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors. Frontiers In Pharmacology 2014, 5: 228. PMID: 25452728, PMCID: PMC4233985, DOI: 10.3389/fphar.2014.00228.Peer-Reviewed Original ResearchDendritic arborsCocaine exposureDendritic spinesPre-existing structural abnormalitiesAdolescent cocaine exposurePostnatal day 31Prior cocaine exposureCocaine-induced modificationsDrugs of abuseDosing protocolDrug-naïveDrug exposureLocomotor activationExcitatory neuronsLong-term effectsAnimal modelsDay 31Structural abnormalitiesOrbitofrontal cortexBehavioral effectsBrain structuresMiceNeurobehavioral phenotypesCocaine vulnerabilityCell populations
2013
Corticosteroid-Induced Neural Remodeling Predicts Behavioral Vulnerability and Resilience
Gourley SL, Swanson AM, Koleske AJ. Corticosteroid-Induced Neural Remodeling Predicts Behavioral Vulnerability and Resilience. Journal Of Neuroscience 2013, 33: 3107-3112. PMID: 23407965, PMCID: PMC3711631, DOI: 10.1523/jneurosci.2138-12.2013.Peer-Reviewed Original ResearchConceptsStressor exposureDendritic spinesDendritic spine densityRecovery periodCA1 pyramidal neuronsHippocampal CA1 neuronsCertain neuron populationsStress hormone exposureStress-related modificationsDistinct brain regionsBehavioral vulnerabilityDendritic retractionPyramidal neuronsCA1 neuronsNeural remodelingSpine densityStress-related diseasesHippocampal CA1Orbital cortexBasal amygdalaDendritic arborsHormone exposureNeuron populationsBrain regionsBrain circuits
2009
Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine
Gourley SL, Koleske AJ, Taylor JR. Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 16859-16864. PMID: 19805386, PMCID: PMC2742404, DOI: 10.1073/pnas.0902286106.Peer-Reviewed Original ResearchConceptsDopamine D2 receptor levelsLocomotor depressant actionsD2 receptor levelsWild-type micePsychomotor stimulant actionDendritic simplificationAntagonist haloperidolStimulant actionCocaine exposureCortical axonsDendritic arborsReceptor levelsCocaine administrationSynaptic pruningDendrite stabilizationNeuropsychiatric disordersArg inhibitionMiceNormal sensitivityDendritic refinementCytoskeletal stabilizationCocaineAdolescenceReversal taskRhoA GTPase