2021
Abl2:Cortactin Interactions Regulate Dendritic Spine Stability via Control of a Stable Filamentous Actin Pool
Shaw JE, Kilander MBC, Lin YC, Koleske AJ. Abl2:Cortactin Interactions Regulate Dendritic Spine Stability via Control of a Stable Filamentous Actin Pool. Journal Of Neuroscience 2021, 41: 3068-3081. PMID: 33622779, PMCID: PMC8026353, DOI: 10.1523/jneurosci.2472-20.2021.Peer-Reviewed Original ResearchConceptsDendritic spine stabilityDendritic spinesSpine stabilityTonic increaseSubset of spinesSexes of miceMost excitatory synapsesCortactin interactionsGluN2B levelsSpine densitySpine lossArg nonreceptor tyrosine kinaseKinetically distinct poolsExcitatory synapsesHippocampal neuronsSynaptic activitySpine enlargementSpineSpine sizeSpine actinActivity-dependent spine enlargementSpine shapeStructural plasticityDistinct poolsTyrosine kinase
2016
Dendrite Maintenance
Katrancha S, Koleske A. Dendrite Maintenance. 2016, 317-355. DOI: 10.1007/978-4-431-56050-0_14.Peer-Reviewed Original ResearchDendritic spinesArbor stabilityDendrite arborsCytoplasmic nonreceptor tyrosine kinaseDendritic spine formationDendritic spine stabilityProper brain functionPsychiatric illnessSpine stabilityDifferent pathological statesSynaptic connectionsSpine formationBrain functionNormal agingNeurodegenerative diseasesMajor contributing factorSpinePathological statesReceptorsArborsEph receptorsContributing factorTyrosine kinaseCell surface adhesion receptorsMolecular mechanisms
2014
Extracellular matrix control of dendritic spine and synapse structure and plasticity in adulthood
Levy AD, Omar MH, Koleske AJ. Extracellular matrix control of dendritic spine and synapse structure and plasticity in adulthood. Frontiers In Neuroanatomy 2014, 8: 116. PMID: 25368556, PMCID: PMC4202714, DOI: 10.3389/fnana.2014.00116.Peer-Reviewed Original ResearchDendritic spinesMost excitatory synapsesCentral nervous systemLate-onset diseaseBrain extracellular matrixExcitatory synapsesExtracellular matrixSynapse stabilityOnset diseaseNervous systemSpine stabilityAlzheimer's diseaseSynapse formationAdult spineSynapse structureAdult animalsSpineDiseaseNormal functionSpine structureCircuit functionCritical regulatorAdulthoodMeshwork of proteinsECM receptors
2013
Molecular mechanisms of dendrite stability
Koleske AJ. Molecular mechanisms of dendrite stability. Nature Reviews Neuroscience 2013, 14: 536-550. PMID: 23839597, PMCID: PMC3947514, DOI: 10.1038/nrn3486.Peer-Reviewed Original Research