2012
Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver
Furlan A, Lamballe F, Stagni V, Hussain A, Richelme S, Prodosmo A, Moumen A, Brun C, del Barco Barrantes I, Arthur JS, Koleske AJ, Nebreda AR, Barilà D, Maina F. Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver. Journal Of Hepatology 2012, 57: 1292-1298. PMID: 22889954, PMCID: PMC3571726, DOI: 10.1016/j.jhep.2012.07.044.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell SurvivalCyclin-Dependent Kinase Inhibitor p21HepatocytesLiverMiceP38 Mitogen-Activated Protein KinasesPhosphorylationProto-Oncogene Proteins c-ablProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-mdm2Proto-Oncogene Proteins c-metTranscription, GeneticTumor Suppressor Protein p53ConceptsHepatocyte survivalRT-PCR arrayHGF/METEmbryonic liverCell survivalP53 transcriptional responseP53 axisP53-dependent cell deathEmbryonic hepatocytesMdm2 upregulationAbstractTextPathway modulationLiverP53 pathwaySurvivalMetSSurvival propertiesTranscriptional responseSurvival genesDeathAIMSCell deathP53 phosphorylationPresent studyP38MAPK
1995
A kinase–cyclin pair in the RNA polymerase II holoenzyme
Liao S, Zhang J, Jeffery D, Koleske A, Thompson C, Chao D, Viljoen M, van Vuuren H, Young R. A kinase–cyclin pair in the RNA polymerase II holoenzyme. Nature 1995, 374: 193-196. PMID: 7877695, DOI: 10.1038/374193a0.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceCyclin-Dependent Kinase 8Cyclin-Dependent KinasesCyclinsFungal ProteinsMolecular Sequence DataMutationProtein Serine-Threonine KinasesRNA Polymerase IISaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSequence Homology, Amino AcidTranscription FactorsTranscription, GeneticConceptsRNA polymerase II holoenzymeSRB proteinsKinase functionRNA polymerase II carboxy-terminal domainCyclin-like proteinGeneral transcription factorsRNA polymerase IISuppressors of mutationsNormal transcriptional responseCarboxy-terminal domainPolymerase IITranscriptional regulatorsTranscriptional responseGalactose inductionTranscription factorsRegulatory proteinsTranscription systemHoloenzymeRegulatory roleKinaseProteinBiochemical evidenceGenesVivoSrb11